QI SHUAI

Dr. Steven Q. Shuai received his BSc from University of Science and Technology of China (USTC) under the supervision of Prof. Lifeng Yan in 2006. He completed his PhD study in Prof. C.-J. Li’s group at McGill University in 2011. After one year of postdoctoral research with Prof. D. F. Perepichka at Department of Chemistry, McGill University, he joined Advanced Polymer Materials (APM) as a Senior Scientist in September 2012 and was promoted to Associate R&D Director in January 2015. In January 2016, Dr. Shuai joined Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals (CICGP). Dr. Shuai’s research focuses on R&D of novel pharmaceutical polymers and nano drug delivery systems, as well as process chemistry of API. 

Pharmaceutical Polymer Material Science, Organic Synthesis, Advances in Medicinal Chemistry, Administrative Engineering of Drug Quality Control.

Publications:

24. Zhao, G.; Ge, T.; Yan, Y.; Shuai, Q.*; Su, W.-K.*, “Highly Efficient Modular Construction of Functional Drug Delivery Platform Based on Amphiphilic Biodegradable Polymers via Click Chemistry”, International Journal of Molecular Sciences, 2021, 22, 10407.

23. Shuai, Q.; Zhu, F.; Zhao, M.; Yan, Y.*, “mRNA delivery via non-viral carriers for biomedical applications”, International Journal of Pharmaceutics, 2021, 607, 121020.

22. Li, M.; Zhao, G.; Su, W.-K.; Shuai, Q.*, “Enzyme-Responsive Nanoparticles for Anti-tumor Drug Delivery”, Front. Chem. 2020, 647.

21. Shuai, Q.; Cai, Y.; Zhao, G.; Sun, X.*, “Cell-Penetrating Peptide Modified PEG-PLA Micelles for Efficient PTX Delivery”, International Journal of Molecular Sciences, 2020, 21, 1856.

20. Cai, Y.; Xu, Z.; Shuai, Q.; Zhu, F.; Xu, J.; Gao, X.; Sun, X.*, “Tumor-targeting peptide functionalized PEG-PLA micelles for efficient drug delivery”, Biomaterials Science, 2020, 8, 2274-2282.

19. Shuai, Q.; Zhao, G.; Lian, X.; Wan. J.; Cen, B.; Zhang, W.; Liu, J.; Su, W.-K.; Wang, H.* “Self-assembling poly(ethylene glycol)-block-polylactide-cabazitaxel conjugate nanoparticles for anticancer therapy with high efficacy and low in vivo toxicity”, International Journal of Pharmaceutics, 2020, 574, 118879.

18. Xie, T.; Jiang, X.; Mi, Z.; Li, X.; Xu, X.; Bai, R.; Shuai, Q.; Xie, Y., “Iron/O₂-Promoted C-H Bond Functionalization for the Exclusive Synthesis of 2-Quinoline Carboxaldehydes under Microwave Irradiation”, Chin. J. Org. Chem. 2019, 39, 3294-3298.

17. Shuai, Q.; Zhao, G.; Zhang, X.; Yu. B.; Lee, R. J.; Su, W.-K.*, “Selection of fluorescent dye for tracking biodistribution of paclitaxel in live imaging”, Colloids and Surfaces B：Biointerfaces 2019, 181, 872-878.

16. Shuai, Q.; Li, J.; Zhao F.; Deng. G.*; Su. W.-K.*, “Metal-Free Chemoselective Reduction of Nitroaromatics to Anilines via Hydrogen Transfer Strategy” Chem. Pap. 2019, 73, 965-975.

15. Gan, B.; Jiang, X.; Mi, Z.; Zhang, C.; Bai, R.; Shuai, Q.; Xie, Y.*, “Straightforward synthesis of amino-3-hydroxypyridin-4-one iron chelators via BBr3-mediated tandem reduction of azides and deprotection of methyl ether”, Synthetic Communications, 2019, 49, 73-79.

14. Yan, Y.; Xu, X.; Jie, X.; Cheng, J.; Bai, R.; Shuai, Q.; Xie, Y.*, “Selective and Facile Synthesis of α，β-Unsaturated nitriles and Amides with N-Hydroxyphthalimide as the Nitrogen Source.” Tetrahedron Lett. 2018, 59, 2793-2796.

13. Xu, X.; Sun, J.; Lin, Y.; Cheng, J.; Li, P.; Yan, Y.; Shuai, Q.*; Xie, Y.*, “Copper Nitrate-Catalyzed Oxidative Coupling of Unactivated C(sp3)-H Bonds of Ethers and Alkanes with N-Hydroxyphthalimide: Synthesis of N-Hydroxyimide Esters.” Org. Biomol. Chem. 2017, 15, 9875.

12. Shuai, Q.; Black, H. T.; Dadvand A.; Perepichka. D. F.* “Dithienonaphthothiadiazole Semiconductors: Synthesis, Properties, and Application to Ambipolar Field Effect Transistors.” J. Mater. Chem. C 2014, 2, 3972. 

11. Rao, H.; Yang, L.; Shuai, Q.; Li, C.-J.* “Rhodium-Catalyzed Aerobic Coupling between Aldehydes and Arenesulfinic Acid Salts: A Novel Synthesis of Aryl Ketones.” Adv. Synth. Catal. 2011, 353, 1701.

10. Xiao, F.; Shuai, Q.; Zhao, F.; Baslé, O.; Deng, G.;* Li, C.-J.* “Palladium-Catalyzed Oxidative sp² C-H Bond Acylation with Alcohols.” Org. Lett. 2011, 7, 1614.

9. Yang, L.; Zeng, T.; Shuai, Q.; Guo, X.; Li, C.-J.* “Phosphine Ligand Triggered Oxidative Decarbonylative Homocoupling of Aromatic Aldehydes: Selectively Generating Biaryls and Diarylketones.” Chem. Commun. 2011, 47, 2161. 

8. Dou, X.; Shuai, Q.; He, L.-N.;* Li, C.-J.* “Rhodium-Catalyzed Arylation of α-Amido Sulfones with Arylboronic Acids in Water-Toluene Biphasic Reaction System.” Inorganica Chimica Acta, 2011, 369, 284. 

7. Feng, C.; Liu, Y.; Peng, S.; Shuai, Q.; Deng, G.;* Li, C.-J.* “Ruthenium-Catalyzed Tertiary Amine Formation from Nitroarenes and Alcohols.” Org. Lett. 2010, 12, 4888. 

6. Dou, X.; Shuai, Q.; He, L.-N.;* Li, C.-J.* “Copper(II) Triflate Catalyzed Three-Component Coupling of Aldehydes, Alkynes and Carbamates.”  Adv. Synth. Catal. 2010, 352, 2437.

5. Shuai, Q.; Yang, L.; Guo, X.; Baslé, O.; Li, C.-J.* “Rhodium-Catalyzed Oxidative C-H Arylation of 2-Arylpyridine Derivatives via Decarbonylation of Aromatic Aldehydes.” J. Am. Chem. Soc. 2010, 132, 12212.

4. Baslé, O.; Bidange, J.; Shuai, Q.; Li, C.-J.* “Palladium-Catalyzed Oxidative sp² C-H Bond Acylation with Aldehydes.” Adv. Synth. Catal. 2010, 352, 1145. 

3. Shuai, Q.; Deng, G.; Chua, Z.; Bohle, D. S.; Li, C.-J.* “Copper-Catalyzed Highly Regioselective Oxidative C-H Bond Amidation of 2-Arylpyridine Derivatives and 1-Methylindoles.” Adv. Synth. Catal. 2010, 352, 632. 

2. Zhou, L.; Shuai, Q.; Jiang, H.-F.; Li, C.-J.* “Copper-Catalyzed Amine-Alkyne-Alkyne Addition Reaction: An Efficient Method for the Synthesis of g,d-Alkynyl-b-Amino Acid Derivatives.” Chem. Eur. J. 2009, 15, 11668. 

1. Yan, L.;* Shuai, Q.; Gong, X.; Gu, Q.; Yu, H. “Synthesis of Microporous Cationic Hydrogel of Hydroxylpropyl Cellulose (HPC) and its Application on Anionic Dye Removal.” Clean-Soil Air Water, 2009, 37, 392.