李汉兵，浙江工业大学副教授，博士生导师、博士后合作导师，药理研究所副所长，耶鲁大学医学院访问副教授；中国病理生理学会蛋白质修饰专业委员会委员，浙江省药理学会理事，浙江省转化医学学会药学分会常务会员，PLOS ONE学术编辑，British Journal of Pharmacology, Trends in Cell Biology, Journal of Functional Foods, Journal of Pharmacy and Pharmacology, Biomedical and Environmental Sciences等期刊审稿人。曾获浙江省第八届高等教育青年教师教学技能竞赛一等奖、浙江工业大学优秀班主任等荣誉；主要研究方向糖尿病、非酒精性脂肪肝、肿瘤等代谢性疾病的发病机理研究、生物标志物、靶标和药物发现；主持主研国家基金、国家重点研发项目子课题、教育部博士点基金、重大企业委托项目等项目10多项，在British Journal of Pharmacology、Advanced Science、Nature Medicine、Biochemical Pharmacology、Pharmacological Research、Biological Reviews、Journal of Biological Chemistry、Journal of Molecular Biology等期刊上发表论文50多篇；申请专利7项；获浙江省细胞生物学会自然科学奖三等奖1项；并承接或参与了多项新药研发项目，积累了比较丰富的药物研发的经验。

教育和工作经历：  

2019.03-2020.05 借调科技部交流中心；

2016.08-2017.09 耶鲁大学医学院，访问副教授

2006.08至今   浙江工业大学，药学院

2003.09-2006.07浙江大学，生物医学工程博士学位

2000.09-2003.07华中科技大学同济医学院，药物化学硕士学位

1996.09-2000.07同济医科大学，药学学士学位

主讲本科生生理学、药理学、药理学实验，研究生高级心血管生理学等课程，主持校级以上教改和课程建设项目6项，发表教改论文3篇，参编教育部规划教材1部，多次获得“优课优酬”奖励。

获得奖励和荣誉：

1.浙江省第八届高等教育青年教师教学技能竞赛一等奖（2014）

2.浙江工业大学第九届青年教师教学技能竞赛十佳（2014）

3.浙江工业大学教学成果二等奖（第二、2012）

4.浙江省微课比赛二等奖（2015）

5.浙江工业大学优秀班主任（2008、2009、2011）

6.浙江工业大学教书育人专项评优奖（2015）  

担任本科生班主任、综合导师等职，指导本科生获第六届全国医药院校药学.中药学专业大学生实验技能竞赛二等奖（2019），第二十六、三十届“运河杯”大学生课外学术科技作品竞赛二等奖（2014、2018）；指导博士研究生3人，硕士研究生35人，其中20人已毕业，其中2人获得国家奖学金，多人获得省级和校级优秀毕业生称号。

2025

1. Li H, Chen G, Lou X, Hu C, Zheng N, He L, Yao Y. Development of MhOR1 as a chemogenetic tool for odorant-mediated regulation      of insulin release. Chem Commun (Camb). 2025 Feb 25;61(18):3744-3747. doi: 10.1039/d5cc00304k.

2024

1. Yao Y, Lou X, Jin L, Sun W, Liu J, Chen Y, Cheng S, Zhao T, Ke S, Zhang L, Xu Y, He L, Li H*. Optogenetic Strategies for Optimizing the Performance of Phospholipids Biosensors. Advanced Science (Weinh). 2024 Jul 29:e2403026.

2. Yao X, Gong Z, Yin W, Li H*, Douroumis D*, Huang L*, Li H*. Islet cell spheroids produced by a thermally sensitive scaffold: a new diabetes treatment. J Nanobiotechnology. 2024 Oct 26;22(1):657. doi: 10.1186/s12951-024-02891-w.

3. Shuwei Ke, Siyu Zhang, Dongsheng Liu, Tengjiao Zhao, Xiayan Lou, Sunying Cheng, Tingheng Zhu, Hanbing Li*. Ectopic OR1A1 activation ameliorates hepatic lipid deposition through AMPK/SREBP-1/FASN pathway by three monoterpenes. Journal of Functional Foods. 2024;115:106097.

4. Lou D, Fang Q, He Y, Ma R, Wang X, Li H*, Qi M*. Oxymatrine alleviates high-fat diet/streptozotocin-induced non-alcoholic fatty liver disease in C57BL/6 J mice by modulating oxidative stress, inflammation and fibrosis. Biomed Pharmacother. 2024 May;174:116491.

5. Li H*, Sun W, Gong W, Han Y. Transfer and fates of damaged mitochondria: role in health and disease. FEBS J. 2024 Mar 28. doi: 10.1111/febs.17119

6. Sun YH, Zhao TJ, Li LH, Wang Z, Li HB*. Emerging role of N6-methyladenosine in the homeostasis of glucose metabolism. Am J Physiol Endocrinol Metab. 2024 Jan 1;326(1):E1-E13. doi: 10.1152/ajpendo.00225.2023

7. Yan Q, Su X, Chen Y, Wang Z, Han W, Xia Q, Mao Y, Si J, Li H*, Duan S*. LINC00941: a novel player involved in the progression of human cancers. Hum Cell. 2024 Jan;37(1):167-180. doi: 10.1007/s13577-023-01002-5. 

8. Xia Q, Shen J, Wang Q, Chen R, Zheng X, Yan Q, Du L, Li H*, Duan S*. Cuproptosis-associated ncRNAs predict breast cancer subtypes. PLoS One. 2024 Feb 26;19(2):e0299138. doi: 10.1371/journal.pone.0299138.

2023

1.      Li H*, Fu G, Zhong W. Natural quinazolinones: From a treasure house to promising anticancer leads. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114915. doi: 10.1016/j.ejmech.2022.114915.

2.      Yao Y^#, Li H^#, Wang X, Sun Y, Zhao X, Zha W, Zhou J, Toomre D, Fu J, Xu Y. Novel function of biguanides in inhibition of phospholipase D1 expression via a translational mechanism in cancer cells. Genes Dis. 2023 Feb 3;10(5):1787-1790. doi: 10.1016/j.gendis.2023.01.007.

3.      Li H*, Gong W, Sun W, Yao Y, Han Y*. Role of VPS39, a key tethering protein for endolysosomal trafficking and mitochondria-lysosome crosstalk, in health and disease. J Cell Biochem. 2023 Mar 16. doi: 10.1002/jcb.30396.

4.      Ke S, Hu Q, Zhu G, Li L, Sun X, Cheng H, Li L, Yao Y, Li H*. Remodeling of white adipose tissue microenvironment against obesity by phytochemicals. Phytother Res. 2023 Feb 14. doi: 10.1002/ptr.7758.

5.      Hong W, Lou B, Gao Y, Zhao H, Ying S, Yang S, Li H, Yang Q, Yang G. Tumor microenvironment responded naturally extracted FOF1-ATPase loaded chromatophores for antitumor therapy. Int J Biol Macromol. 2023 Mar 1;230:123127. doi: 10.1016/j.ijbiomac.2022.123127.

2022

1.      Li L, Sun Y, Zha W, Li L, Li H*. Novel insights into the N6-methyladenosine RNA modification and phytochemical intervention in lipid metabolism. Toxicol Appl Pharmacol. 2022 Nov 24;457:116323. doi: 10.1016/j.taap.2022.116323.

2.     Guo Y, Li L, Yao Y, Li H*. Regeneration of Pancreatic β-Cells for Diabetes Therapeutics by Natural DYRK1A Inhibitors. Metabolites. 2022 Dec 29;13(1):51. doi: 10.3390/metabo13010051.

3.      Zha W, Sun Y, Gong W, Li L, Kim W, Li H*. Ginseng and ginsenosides: Therapeutic potential for sarcopenia. Biomed Pharmacother. 2022 Dec;156:113876. doi: 10.1016/j.biopha.2022.113876.

4.      Li L, Zhu G, Fu G, Zha W, Li H*. Metabolic Syndrome Ameliorated by 4-Methylesculetin by Reducing Hepatic Lipid Accumulation. Int J Mol Sci. 2022 Sep 9;23(18):10465. doi: 10.3390/ijms231810465.

5.      Zheng W, Li L, Li H*. Phytochemicals modulate pancreatic islet β cell function through glucagon-like peptide-1-related mechanisms. Biochemical Pharmacology. 2022 Mar;197:114817. doi: 10.1016/j.bcp.2021.114817.

2021

1.      Zhang S, Li L, Li H. Role of ectopic olfactory receptors in glucose and lipid metabolism. British Journal of Pharmacology. 2021 Aug 19. doi: 10.1111/bph.15666. PMID: 34411276.

2.      Hanbing Li*, Can Wang, Linghuan Li, Lingqiao Li. Skeletal muscle non-shivering thermogenesis as an attractive strategy to combat obesity.Life Sciences 2021 Jan 12;269:119024.doi: 10.1016/j.lfs.2021.119024.

3.      Habtemichael EN, Li DT, Camporez JP, Westergaard XO, Sales CI, Liu X, López-Giráldez F, DeVries SG, Li H, Ruiz DM, Wang KY, Sayal BS, González Zapata S, Dann P, Brown SN, Hirabara S, Vatner DF, Goedeke L, Philbrick W, Shulman GI, Bogan JS. Insulin-stimulated endoproteolytic TUG cleavage links energy expenditure with glucose uptake. Nat Metab. 2021 Mar;3(3):378-393. doi: 10.1038/s42255-021-00359-x. Epub 2021 Mar 8.

2020

1.      Li LH, Zheng WF, Wang C, Qi JM, Li HB*. Mogroside V Protects against Hepatic Steatosis in Mice on a High-Fat Diet and LO2 Cells Treated with Free Fatty Acids via AMPK Activation.Evidence-Based Complementary and Alternative Medicine 2020:7826874.DOI: 10.1155/2020/7826874.

2.      Hanbing Li, Ping Shentu, Mei Xiao, Xuqin Zhao, Jiannan Fan, Xuechun Liu, Yinyan Lin, Lei Wang, Hong Li, Xiaogang Guo, Olof Idevall-Hagren, Yingke Xu*. Dual Function of PI(4,5)P 2 in Insulin-Regulated Exocytic Trafficking of GLUT4 in Adipocytes.Journal of Molecular Biology 2020. DOI: 10.1016/j.jmb.2020.06.019.

3.      Huawei Lv, Yuxia Li, Mengdi Zhu, Meng Luo, Jiameng Qi, Zhefeng Yu, Hongjian Zhang, Yuanqiang Guo, Shengqiang Tong, Hanbing Li*, Jizhong Yan*. A cyclic peptide and two pairs of norlignan lignanoside epimers from Selaginella pulvinata. Fitoterapia 2020,143:104562. DOI: 10.1016/j.fitote.2020.104562.

4.      Hua-Wei Lv, Yu-Xia Li , Meng Luo, Jia-Meng Qi, Ze-Fei Fu, Hong-Jian Zhang, Yuan-Qiang Guo, Chu Chu, Hanbing Li*, Jizhong Yan*. Two new nor-lignans from Selaginella pulvinata (Hook. & Grev.) Maxim and their antihyperglycemic activities. Natural Product Research: 2020:1-8.

5.      Yao Y, Wang X, Li H, Fan J, Qian X, Li H, Xu Y*. Phospholipase D as a key modulator of cancer progression.Biological Reviews.Biol Rev Camb Philos Soc. 2020 Aug;95(4):911-935.

2019

1.      Li H, Qi J, Li H*. Phytochemicals as potential candidates to combat obesity via adipose non-shivering thermogenesis. Pharmacological Research. 2019 Aug 8;147:104393.

2.      Mo Z, Li L, Yu H, Wu Y, Li H*. Coumarins ameliorate diabetogenic action of dexamethasone via Akt activation and AMPK signaling in skeletal muscle. Journal of Pharmacological Sciences. 2019 Jan 23. doi: 10.1016/j.jphs.2019.01.001.

3.      Lee G, Kim W, Kim W, Li HB. Modernization of Traditional Oriental Medicine: New Dosage Forms and Medical Instruments. Evid Based Complement Alternat Med. 2018 Jun 10;2018:6960125. doi: 10.1155/2018/6960125 (Editorial).

4.      Li L, Qi J, Li H*. Natural Products Modulating Autophagy Pathway against the Pathogenesis of Diabetes Mellitus. Current Drug Targets. 2019;20(1):96-110. doi: 10.2174/1389450119666180726115805. 

5.      李汉兵*，赵旭琴，王心怡，戚佳梦，王灿，姚元发. 二甲双胍不依赖腺苷酸活化蛋白激酶途径的抗肿瘤机制研究进展. 中国药理学与毒理学杂志. 2019;(33)7:525-534.

2018

1.      Yuanfa Yao, Xuqin Zhao, Jingxia Xin, Yingqi Wu, Hanbing Li*. Coumarins improved type 2 diabetes induced by high-fat diet and streptozotocin in mice via antioxidation. Canadian Journal of Physiology and Pharmacology. 2018 Apr 11. doi: 10.1139/cjpp-2017-0612. 

2.      Habtemichael EN, Li DT, Alcázar-Román A, Westergaard XO, Li M, Petersen MC, Li H, DeVries SG, Li E, Julca-Zevallos O, Wolenski JS, Bogan JS*. Usp25m protease regulates ubiquitin-like processing of TUG proteins to control GLUT4 glucose transporter translocation in adipocytes. Journal of Biological Chemistry. 2018 Jul 6;293(27):10466-10486.

3.      Guo F, Huang D, Zhang W, Yan Q, Yang Q, Yang Y, Li H, Yun J, Hong W, Yang G*. Star-shaped polyester-based elastomers as an implantable delivery system for insulin: Development, pharmacokinetics, pharmacodynamics, and biocompatibility. Mater Sci Eng C Mater Biol Appl. 2018;84:180-187. 

4.      肖玫; 赵旭琴; 许迎科; 李汉兵*. 磷脂酰肌醇信号在GLUT4囊泡转运中的调控作用. 中国细胞生物学学报, 2018.1, 40(1): 139~145.

2017

1.      Hanbing Li*, Yuanfa Yao, Linghuan Li. Coumarins as potential antidiabetic agents. Journal of Pharmacy and Pharmacology. 2017;69(10):1253-1264.

2.      Hanbing Li, Liting Ou, Jiannan Fan, Mei Xiao, Cuifang Kuang, Xu Liu, Yonghong Sun, Yingke Xu*. Rab8A regulates insulin-stimulated GLUT4 translocation in C2C12 myoblasts. FEBS Letters. 2017 Feb;591(3):491-499. 

2016及以前

1.      李灵欢, 姚元发, 李汉兵. PM2.5对胰岛素抵抗的影响及机制研究进展.中国药理学与毒理学杂志. 2016.11, 30(11): 1230~1236.

2.      欧丽婷; 许迎科; 李汉兵*. Rab蛋白调控葡萄糖转运蛋白4转运机制的研究进展. 中国药理学与毒理学杂志. 2016.7, 30(7): 770~776.

3.      Hanbing Li*, Silibinin improves palmitate-induced insulin resistance in C2C12 myotubes by attenuating IRS-1/PI3K/Akt pathway inhibition. Brazilian Journal of Medical and Biological Research, 2015;48(5): 440-446.

4.      Hanbing Li*, Yunxue Pan, Jing Nie. Astragaloside IV improved insulin resistance in L6 myotubes induced by high glucose and insulin. Inernational Conference on Remote Sensing, Enviroment and Transportantion Engineering (RSETE), 2011,7515-7518. (ISBN: 978-1-4244-9172-8; doi: 10.1109/RSETE.2011.5966083)

5.      Han-Bing Li*, Ya-Kun Ge, Xiao-Xiang Zheng, Le Zhang. Salidroside stimulated glucose uptake in skeletal muscle cells by activating AMP-activated protein kinase. European Journal of Pharmacology 2008,588:165-169. 

6.      Han-Bing Li, Ya-Kun Ge, Le Zhang, Xiao-Xiang Zheng*. Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells. Life Sciences 2006,79:1186-1193.

7.      Han-Bing Li, Tong-Le Deng, Qing-Nan Zhang, Xiao-Xiang Zheng*. Label-free and Dynamic Monitoring of Endothelial Barrier Function on Microelectronic Cell Sensor Arrays. Chinese Journal of Cell Biology 2007,29:91-96 (ISSN: 1674-7666).

8.      Xiaoxiang Zheng, Yun Zhang, Wei Yuan, Xiaolong Li, Hanbing Li, Weimin Yan. A series of methods For screening and evaluating potential anti-cardiovascular drugs from traditional Chinese herbs, Recent progress in medicinal plants, volume 25(Chemistry and medicinal value), U.S.A. Studium Press LLC, 2009:185-201.

2009.11-2011.03 受浙江省省委组织部“希望之光”计划委派，挂职开化县经贸局副局长，服务于校地合作和地方经济建设。