Sundongchang

Research directions include CRISPR gene editing and regulation, microbial pharmaceuticals, synthetic biology, and horizontal gene transfer. Awarded three grants from National Science Foundation of China. Published more than 20 papers in international journals such as Biotechnol Adv, ACS Synth Biol, Appl Env Microbiol, J Bacteriol. Selected as the reviewer for evaluating grants from Agence national de la recherche (France),National Science Center (Poland)，NationalScience Foundation (China) and ETH Zurich. Invited as the guest editor for the journal Front Microbiol, reviewers for journals including Synth Syst Biotechnol, Biotechnol J, Appl Biochem Biotechnol, etc. 

Representative Publications

1. Yuan P*, Xu M, Mao C, Zheng H, Sun D*. 2023. Dynamically regulating glucose uptake to reduce overflow metabolism with a quorum-sensing circuit for the efficient synthesis of d-pantothenic acid in Bacillus subtilis. ACS Synth Biol. (Published online, DOI：https://doi.org/10.1021/acssynbio.3c00315. 

2. Yu M, Hu S, Tang B, Yang H, Sun D*. 2023. Engineering Escherichia coli Nissle 1917 as a microbial chassis for therapeutic and industrial applications. Biotechnol Adv.  Jun 19:108202. doi: 10.1016/j.biotechadv.2023.108202. Epub ahead of print. PMID: 37343690. 

3. Sun D*, Sun X*, Hu Y*, Yamaichi Y*. 2023. Editorial: Horizontal gene transfer mediated bacterial antibiotic resistance, volume II. Front Microbiol. 14:1221606. doi: 10.3389/fmicb.2023.1221606 

4. Hu S, Fei M, Fu B, Yu M, Yuan P, Tang B, Yang H. Sun D*. 2023. Development of probiotic E. coli Nissle 1917 for β‑alanine production by using protein and metabolic engineering. Appl Microbiol Biotechnol. 107(7-8): 2277-2288

5. Chen Z, Shen M, Mao C, Wang C, Yuan P, Wang T, Sun D*. 2021. A type I restriction-modification system influences genomic evolution driven by horizontal gene transfer in Paenibacillus polymyxa. Front Microbiol. 12: 709571. DOI：10.3389/fmicb.2021.709571

6. Sun D*, Mao X, Fei M, Chen Z, Zhu T, Qiu J. 2020. Histone-like nucleoid-structuring protein (H-NS) paralogue StpA activates the type I-E CRISPR-Cas system against natural transformation in Escherichia coli. Appl Environ Microbiol. 86:e00731-20. DOI：10.1128/AEM.00731-20 

7. Fei M，Mao X，Chen Y，Lu Y ，Wang L，Yang J ，Qiu J，Sun D*. 2020. Development of a dual-fluorescence reporter system for high-throughput screening of L-aspartate-a-decarboxylase. Acta Bioch Bioph Sin. 52(12):1420-1426. DOI: 10.1093/abbs/gmaa134 

8. Sun D*, Jeannot K*, Xiao YH*, Knapp CW*. 2019. Editorial: horizontal gene transfer mediated bacterial antibiotic resistance. Front Microbiol. 10:1933. DOI: 10.3389/fmicb.2019.01933 

9. Sun D. 2018. Pull in and push out: mechanisms of horizontal gene transfer in bacteria. Front Microbiol 9:2154. DOI: 10.3389/fmicb.2018.02154 

10. Shen M, Chen Z, Mao X, Wang L, Liang J, Huo Q, Yin X, Qiu J, Sun D*. 2018. Two different restriction-modification systems for degrading exogenous DNA in Paenibacillus polymyxa. Biochem Biophys Res Commun 504:927-932. DOI: 10.1016/j.bbrc.2018.09.016. 

11. Sun D. 2016. Two different routes for double-stranded DNA transfer in natural and artificial transformation of Escherichia coli. Biochem Biophys Res Commun 471:213-8. DOI：10.1016/j.bbrc.2016.01.137. 

12. Wang B, Sun D*. 2015. Detection of NDM-1 carbapenemase-producing Acinetobacter calcoaceticus and Acinetobacter junii in environmental samples from livestock farms. J Antimicrob Chemother 70:611-3. DOI：10.1093/jac/dku405