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更新时间：2024.08.20
总访问量：10
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孙李真| 博士 副教授 硕士生导师 |
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单位： 职务： 研究方向： 办公地址： 屏峰校区理学楼A-308 办公电话： 电子邮箱： sunlizhen@zjut.edu.cn |
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浙江工业大学理学院副教授，理论物理教师党支部书记。
2013年6月获得浙江大学理学博士学位，同年进入浙江工业大学理学院工作；2015年-2017年赴美国密苏里大学从事博士后研究工作。
研究方向集中于凝聚态物理的计算机模拟，主要包括核酸分子动力学、核酸分子-金属离子相互作用等。迄今已主持多项国家以及浙江省自然科学基金项目，发表SCI收录论文40余篇。
主持科研项目：
3.《基于纳米孔的单链核酸探测中离子复杂效应和调控机制研究》，浙江省自然科学基金重点项目，Z24A040003，2024-01至2026-12，在研
2.《RNA折叠与对接过程中离子复杂结合效应的研究》，国家自然科学基金青年项目，11704333，2018-01至2020-12，结题
1.《利用移位运动进行生物大分子测序的模拟研究》，浙江省自然科学基金一般项目，Q14A040004，2014-01至2016-12，结题
(2024)
47. Y. F. Rao, L. Z. Sun*, and M. B. Luo*. Na+-Mg2+ ion effects on conformation and translocation dynamics of single-stranded RNA: Cooperation and competition. Int. J. Biol. Macromol. (in press). DOI: 10.1016/j.ijbiomac.2024.131273
46. C. S. Zuo, K. Wang, L. Z. Sun*, and T. T. Sun*. Molecular chaperone-dependent polymer translocation through nanopores: The effects of chaperone concentration and chaperone-polymer interaction. Chinese. J. Polym. Sci. 2024, 42, 125-132.
(2023)
45. L. Z. Sun* and Y. J. Ying. Moving dynamics of a nanorobot with three DNA legs on nanopore-based tracks. Nanoscale. 2023, 15, 15794-15809.
44. J. L. Qian, H. Li, and L. Z. Sun*. The translocation of a polymer through a nanopore with sandglass-like geometry. J. Polym. Sci. 2023, 61, 3136-3148.
(2022)
43. L. Z. Sun*, J. L. Qian, P. Cai, H. X. Hu, X. Xu, and M. B. Luo. Mg2+ effects on the single-stranded DNA conformations and nanopore translocation dynamics. Polymer 2022, 250, 124895.
42. L. Z. Sun*, J. L. Qian, P. Cai, and X. Xu. Mutual effects between single-stranded DNA conformation and Na+-Mg2+ ion competition in mixed salt solutions. Phys. Chem. Chem. Phys. 2022, 24, 20867.
41. J. L. Qian and L. Z. Sun*. Dataset of normalized probability distributions of virtual bond lengths, bond angles, and dihedral angles for the coarse-grained single-stranded DNA structures. Data in Brief. 2022, 42, 108284.
(2021)
40. J. Chen, X. Chen, L. Z Sun*, X. Xu, and M. B. Luo*. Translocation of a looped polymer threading through a nanopore. Soft Matter. 2021, 17, 4342-4351.
39. L. Z. Sun*, W. P. Cao, C. H. Wang, and X. Xu*. The translocation dynamics of the polymer through a conical pore: Non-stuck, weak-stuck, and strong-stuck modes. J. Chem. Phys. 2021, 154, 054903.
38. Q. M. Nie, L. Z. Sun, H. B. Li, X. Chu*, and J. Wang*. Effects of electrostatic interactions on global folding and local conformational dynamics of a multidomain Y-family DNA polymerase. Phys. Chem. Chem. Phys. 2021, 23, 20841-20847.
(2020)
37. L. Z. Sun, Y. Jiang, Y. Zhou, and S. J. Chen*. RLDOCK: A new method for predicting RNA-ligand interactions. J. Chem. Theory Comput. 2020, 16, 7173-7183.
(2019)
36. C. H. Wang, M. B. Luo, X. Xu, C. Wang, and L. Z. Sun*. Effects of salt concentration on the polyelectrolyte translocation through a cylinder nanopore. Eur. Polym. J. 2019, 121, 109332.
35. L. Z. Sun, Y. Zhou, and S. J. Chen*. Predicting monovalent ion correlation effects in nucleic acids. ACS Omega 2019, 4, 13435-13446.
34. L. Z. Sun, Q. Nie, and H. Li*. Randomness of eigenstates of many-body quantum systems. Entropy 2019, 21, 227.
33. L. Z. Sun and S. J. Chen*. Predicting RNA-metal ion binding with ion dehydration effects. Biophys. J. 2019, 116, 184-195.
32. L. Z. Sun, C. H. Wang, M. B. Luo, and H. Li*. Trapped and non-trapped polymer translocations through a spherical pore. J. Chem. Phys., 2019, 150, 024904.
31. F. Wang, L. Z. Sun, P. Cai, S. J. Chen*, and X. Xu*. Kinetic Mechanism of RNA Helix-Terminal Basepairing-A Kinetic Minima Network Analysis. Biophys. J. 2019, 117, 1674-1683.
30. F. Wang, L. Z. Sun, T. Sun, S. Chang, and X. Xu*. Helix-Based RNA Landscape Partition and Alternative Secondary Structure Determination. ACS Omega 2019, 4, 15407-15413.
29. F. Wu, Y. Fu, X. Yang, L. Z. Sun, and M. B. Luo*. Driven translocation of semiflexible polyelectrolyte through a nanopore. J. Polym. Sci. B-Polym. Phys. 2019, 57, 912-921.
28. M. B. Luo*, F. Wu, S. Zhang, and L. Z. Sun. Effect of temperature on the escape of charged polymer chain from a repulsive nanopore. Mol. Simul. 2019, 45, 1044-1050.
27. C. Wang, Y. L. Zhou, L. Z. Sun, Y. C. Chen*, and M. B. Luo*. Simulation study on the migration of diblock copolymers in periodically patterned slits. J. Chem. Phys. 2019, 150, 164904.
(2018)
26. L. Z. Sun*, H. Li, X. Xu, and M. B. Luo*. Simulation study on the translocation of polyelectrolyte through conical nanopores. J. Phys.: Condensed Matt. 2018, 30, 495101.
25. L. Z. Sun*, M. B. Luo, W. P. Cao, and H. Li*. Theoretical study on the polymer translocation into an attractive sphere. J. Chem. Phys. 2018, 149, 024901.
(2017)
24. L. Z. Sun, C. Kranawetter, X. Heng*, and S. J. Chen*. Predicting ion effects in an RNA conformational equilibrium. J. Phys. Chem. B 2017, 121, 8026-8036.
23. L. Z. Sun, J. X. Zhang, and S. J. Chen*. MCTBI: A web server for predicting metal ion effects in RNA structures. RNA 2017, 23, 1155-1165.
22. L. Z. Sun+, D. Zhang+, and S. J. Chen*. Theory and modeling of RNA structure and interactions with metal ions and small molecules. Annu. Rev. Biophys., 2017, 46, 227-246.
21. L. Z. Sun, Xiao Heng*, and S. J. Chen*. Theory meets experiment: Metal ion effects in HCV genomic RNA kissing complex formation. Front. Mol. Biosci. 2017, 4, 92.
20. C. Kranawetter, S. Brady, L. Z. Sun, M. Schroeder, S. J. Chen*, and X. Heng*. NMR study of RNA structures in the 3´-end of the Hepatitis C Virus genome. Biochemistry. 2017, 56, 4972-4984.
19. L. Z. Sun and S. J. Chen*. A new method to predict ion effects in RNA folding. Methods Mol Biol. 2017, 1632, 1-17.
18. M. B. Luo*, D. A. Tsehay, and L. Z. Sun. Temperature dependence of the translocation time of polymer through repulsive nanopores. J. Chem. Phys. 2017, 147, 034901.
17. M. B. Luo*, S. Zhang, F. Wu, and L. Z. Sun. Translocation time of a polymer chain through an energy gradient nanopore. Front. Phys. 2017, 12, 128301.
(2016)
16. L. Z. Sun and S. J. Chen*. Monte Carlo tightly bound ion model: Predicting ion-binding properties of RNA with ion correlations and fluctuations. J. Chem. Theory Comput. 2016, 12, 3370.
15. Q. B. Ren, S. H. Ma, Y. J. Chen, L. Z. Sun, and W. P. Cao*. Numerical simulation on polymer translocation into crowded environment with nanoparticles. Col. Polym. Sci. 2016, 294, 1351-1357.
(Before 2016)
14. L. Z. Sun and M. B. Luo*. Langevin dynamics simulation on the translocation of polymer through α-hemolysin pore. J. Phys.: Condens. Matter 2014, 26, 415101.
13. L. Z. Sun and M. B. Luo*. Study on the polymer translocation induced blockade ionic current inside a nanopore by Langevin dynamics simulation. J. Phys.: Condens. Matter 2013, 25, 465101.
12. L. Z. Sun and M. B. Luo*. Simulation study on the translocation and separation of copolymers. Polymer 2013, 54, 1448.
11. C. Wang, Y. C. Chen, L. Z. Sun, and M. B. Luo*. Simulation on the translocation of polymer through compound channels. J. Chem. Phys. 2013, 138, 044903.
10. S. Zhang, C. Wang, L. Z. Sun, and M. B. Luo*. Polymer translocation through a gradient channel. J. Chem. Phys. 2013, 139, 044902.
9. H. Qian, L. Z. Sun, and M. B. Luo*. Simulation study on the translocation of a partially charged polymer through a nanopore. J. Chem. Phys. 2012, 137, 034903.
8. L. Z. Sun, W. P. Cao, and M. B. Luo*. Translocation properties of copolymer (AnBm)l through an interacting pore. Phys. Rev. E 2011, 84, 041912.
7. W. P. Cao, L. Z. Sun, W. Chao, and M. B. Luo*. Dynamical modes of polymer translocating through interacting pore under chemical potential difference. Inter. J. Mod. Phys. B 2011, 25, 3345.
6. W. P. Cao, L. Z. Sun, W. Chao, and M. B. Luo*. Monte Carlo simulation on polymer translocation in crowded environment. J. Chem. Phys. 2011, 135, 174901.
5. H. Li, C. J. Qian, L. Z. Sun, and M. B. Luo*. Conformational properties of a polymer tethered to an interacting flat surface. Polymer Journal 2010, 42, 383
4. L. Z. Sun, W. P. Cao, and M. B. Luo*. Simulation study on the translocation of diblock copolymer AnBn through interacting nanopores. Phys. Chem. Chem. Phys. 2010, 12, 13318.
3. L. Z. Sun, W. P. Cao, and M. B. Luo*. Free energy landscape for the translocation of polymer through an interacting pore. J. Chem. Phys. 2009, 131, 194904.
2. L. Z. Sun and M. B. Luo*. Hard Sphere Diffusion Behaviour of Polymer Translocating through Interacting Pores. Chin. Phys. Lett. 2008, 25, 4050.
1. W. Zhang, L. Z. Sun, and M. B. Luo*. Simulation of Dynamics in Two-Dimensional Vortex Systems in Random Media. Chin. Phys. Lett. 2009, 26, 027402
浙江工业大学理学院副教授，理论物理教师党支部书记。
2013年6月获得浙江大学理学博士学位，同年进入浙江工业大学理学院工作；2015年-2017年赴美国密苏里大学从事博士后研究工作。
研究方向集中于凝聚态物理的计算机模拟，主要包括核酸分子动力学、核酸分子-金属离子相互作用等。迄今已主持多项国家以及浙江省自然科学基金项目，发表SCI收录论文40余篇。
主持科研项目：
3.《基于纳米孔的单链核酸探测中离子复杂效应和调控机制研究》，浙江省自然科学基金重点项目，Z24A040003，2024-01至2026-12，在研
2.《RNA折叠与对接过程中离子复杂结合效应的研究》，国家自然科学基金青年项目，11704333，2018-01至2020-12，结题
1.《利用移位运动进行生物大分子测序的模拟研究》，浙江省自然科学基金一般项目，Q14A040004，2014-01至2016-12，结题
(2024)
47. Y. F. Rao, L. Z. Sun*, and M. B. Luo*. Na+-Mg2+ ion effects on conformation and translocation dynamics of single-stranded RNA: Cooperation and competition. Int. J. Biol. Macromol. (in press). DOI: 10.1016/j.ijbiomac.2024.131273
46. C. S. Zuo, K. Wang, L. Z. Sun*, and T. T. Sun*. Molecular chaperone-dependent polymer translocation through nanopores: The effects of chaperone concentration and chaperone-polymer interaction. Chinese. J. Polym. Sci. 2024, 42, 125-132.
(2023)
45. L. Z. Sun* and Y. J. Ying. Moving dynamics of a nanorobot with three DNA legs on nanopore-based tracks. Nanoscale. 2023, 15, 15794-15809.
44. J. L. Qian, H. Li, and L. Z. Sun*. The translocation of a polymer through a nanopore with sandglass-like geometry. J. Polym. Sci. 2023, 61, 3136-3148.
(2022)
43. L. Z. Sun*, J. L. Qian, P. Cai, H. X. Hu, X. Xu, and M. B. Luo. Mg2+ effects on the single-stranded DNA conformations and nanopore translocation dynamics. Polymer 2022, 250, 124895.
42. L. Z. Sun*, J. L. Qian, P. Cai, and X. Xu. Mutual effects between single-stranded DNA conformation and Na+-Mg2+ ion competition in mixed salt solutions. Phys. Chem. Chem. Phys. 2022, 24, 20867.
41. J. L. Qian and L. Z. Sun*. Dataset of normalized probability distributions of virtual bond lengths, bond angles, and dihedral angles for the coarse-grained single-stranded DNA structures. Data in Brief. 2022, 42, 108284.
(2021)
40. J. Chen, X. Chen, L. Z Sun*, X. Xu, and M. B. Luo*. Translocation of a looped polymer threading through a nanopore. Soft Matter. 2021, 17, 4342-4351.
39. L. Z. Sun*, W. P. Cao, C. H. Wang, and X. Xu*. The translocation dynamics of the polymer through a conical pore: Non-stuck, weak-stuck, and strong-stuck modes. J. Chem. Phys. 2021, 154, 054903.
38. Q. M. Nie, L. Z. Sun, H. B. Li, X. Chu*, and J. Wang*. Effects of electrostatic interactions on global folding and local conformational dynamics of a multidomain Y-family DNA polymerase. Phys. Chem. Chem. Phys. 2021, 23, 20841-20847.
(2020)
37. L. Z. Sun, Y. Jiang, Y. Zhou, and S. J. Chen*. RLDOCK: A new method for predicting RNA-ligand interactions. J. Chem. Theory Comput. 2020, 16, 7173-7183.
(2019)
36. C. H. Wang, M. B. Luo, X. Xu, C. Wang, and L. Z. Sun*. Effects of salt concentration on the polyelectrolyte translocation through a cylinder nanopore. Eur. Polym. J. 2019, 121, 109332.
35. L. Z. Sun, Y. Zhou, and S. J. Chen*. Predicting monovalent ion correlation effects in nucleic acids. ACS Omega 2019, 4, 13435-13446.
34. L. Z. Sun, Q. Nie, and H. Li*. Randomness of eigenstates of many-body quantum systems. Entropy 2019, 21, 227.
33. L. Z. Sun and S. J. Chen*. Predicting RNA-metal ion binding with ion dehydration effects. Biophys. J. 2019, 116, 184-195.
32. L. Z. Sun, C. H. Wang, M. B. Luo, and H. Li*. Trapped and non-trapped polymer translocations through a spherical pore. J. Chem. Phys., 2019, 150, 024904.
31. F. Wang, L. Z. Sun, P. Cai, S. J. Chen*, and X. Xu*. Kinetic Mechanism of RNA Helix-Terminal Basepairing-A Kinetic Minima Network Analysis. Biophys. J. 2019, 117, 1674-1683.
30. F. Wang, L. Z. Sun, T. Sun, S. Chang, and X. Xu*. Helix-Based RNA Landscape Partition and Alternative Secondary Structure Determination. ACS Omega 2019, 4, 15407-15413.
29. F. Wu, Y. Fu, X. Yang, L. Z. Sun, and M. B. Luo*. Driven translocation of semiflexible polyelectrolyte through a nanopore. J. Polym. Sci. B-Polym. Phys. 2019, 57, 912-921.
28. M. B. Luo*, F. Wu, S. Zhang, and L. Z. Sun. Effect of temperature on the escape of charged polymer chain from a repulsive nanopore. Mol. Simul. 2019, 45, 1044-1050.
27. C. Wang, Y. L. Zhou, L. Z. Sun, Y. C. Chen*, and M. B. Luo*. Simulation study on the migration of diblock copolymers in periodically patterned slits. J. Chem. Phys. 2019, 150, 164904.
(2018)
26. L. Z. Sun*, H. Li, X. Xu, and M. B. Luo*. Simulation study on the translocation of polyelectrolyte through conical nanopores. J. Phys.: Condensed Matt. 2018, 30, 495101.
25. L. Z. Sun*, M. B. Luo, W. P. Cao, and H. Li*. Theoretical study on the polymer translocation into an attractive sphere. J. Chem. Phys. 2018, 149, 024901.
(2017)
24. L. Z. Sun, C. Kranawetter, X. Heng*, and S. J. Chen*. Predicting ion effects in an RNA conformational equilibrium. J. Phys. Chem. B 2017, 121, 8026-8036.
23. L. Z. Sun, J. X. Zhang, and S. J. Chen*. MCTBI: A web server for predicting metal ion effects in RNA structures. RNA 2017, 23, 1155-1165.
22. L. Z. Sun+, D. Zhang+, and S. J. Chen*. Theory and modeling of RNA structure and interactions with metal ions and small molecules. Annu. Rev. Biophys., 2017, 46, 227-246.
21. L. Z. Sun, Xiao Heng*, and S. J. Chen*. Theory meets experiment: Metal ion effects in HCV genomic RNA kissing complex formation. Front. Mol. Biosci. 2017, 4, 92.
20. C. Kranawetter, S. Brady, L. Z. Sun, M. Schroeder, S. J. Chen*, and X. Heng*. NMR study of RNA structures in the 3´-end of the Hepatitis C Virus genome. Biochemistry. 2017, 56, 4972-4984.
19. L. Z. Sun and S. J. Chen*. A new method to predict ion effects in RNA folding. Methods Mol Biol. 2017, 1632, 1-17.
18. M. B. Luo*, D. A. Tsehay, and L. Z. Sun. Temperature dependence of the translocation time of polymer through repulsive nanopores. J. Chem. Phys. 2017, 147, 034901.
17. M. B. Luo*, S. Zhang, F. Wu, and L. Z. Sun. Translocation time of a polymer chain through an energy gradient nanopore. Front. Phys. 2017, 12, 128301.
(2016)
16. L. Z. Sun and S. J. Chen*. Monte Carlo tightly bound ion model: Predicting ion-binding properties of RNA with ion correlations and fluctuations. J. Chem. Theory Comput. 2016, 12, 3370.
15. Q. B. Ren, S. H. Ma, Y. J. Chen, L. Z. Sun, and W. P. Cao*. Numerical simulation on polymer translocation into crowded environment with nanoparticles. Col. Polym. Sci. 2016, 294, 1351-1357.
(Before 2016)
14. L. Z. Sun and M. B. Luo*. Langevin dynamics simulation on the translocation of polymer through α-hemolysin pore. J. Phys.: Condens. Matter 2014, 26, 415101.
13. L. Z. Sun and M. B. Luo*. Study on the polymer translocation induced blockade ionic current inside a nanopore by Langevin dynamics simulation. J. Phys.: Condens. Matter 2013, 25, 465101.
12. L. Z. Sun and M. B. Luo*. Simulation study on the translocation and separation of copolymers. Polymer 2013, 54, 1448.
11. C. Wang, Y. C. Chen, L. Z. Sun, and M. B. Luo*. Simulation on the translocation of polymer through compound channels. J. Chem. Phys. 2013, 138, 044903.
10. S. Zhang, C. Wang, L. Z. Sun, and M. B. Luo*. Polymer translocation through a gradient channel. J. Chem. Phys. 2013, 139, 044902.
9. H. Qian, L. Z. Sun, and M. B. Luo*. Simulation study on the translocation of a partially charged polymer through a nanopore. J. Chem. Phys. 2012, 137, 034903.
8. L. Z. Sun, W. P. Cao, and M. B. Luo*. Translocation properties of copolymer (AnBm)l through an interacting pore. Phys. Rev. E 2011, 84, 041912.
7. W. P. Cao, L. Z. Sun, W. Chao, and M. B. Luo*. Dynamical modes of polymer translocating through interacting pore under chemical potential difference. Inter. J. Mod. Phys. B 2011, 25, 3345.
6. W. P. Cao, L. Z. Sun, W. Chao, and M. B. Luo*. Monte Carlo simulation on polymer translocation in crowded environment. J. Chem. Phys. 2011, 135, 174901.
5. H. Li, C. J. Qian, L. Z. Sun, and M. B. Luo*. Conformational properties of a polymer tethered to an interacting flat surface. Polymer Journal 2010, 42, 383
4. L. Z. Sun, W. P. Cao, and M. B. Luo*. Simulation study on the translocation of diblock copolymer AnBn through interacting nanopores. Phys. Chem. Chem. Phys. 2010, 12, 13318.
3. L. Z. Sun, W. P. Cao, and M. B. Luo*. Free energy landscape for the translocation of polymer through an interacting pore. J. Chem. Phys. 2009, 131, 194904.
2. L. Z. Sun and M. B. Luo*. Hard Sphere Diffusion Behaviour of Polymer Translocating through Interacting Pores. Chin. Phys. Lett. 2008, 25, 4050.
1. W. Zhang, L. Z. Sun, and M. B. Luo*. Simulation of Dynamics in Two-Dimensional Vortex Systems in Random Media. Chin. Phys. Lett. 2009, 26, 027402
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更新时间：2024.08.20
总访问量：10
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