杨庆良

  浙江工业大学药学院副教授，主要研究领域为微纳递药颗粒的设计构建关键技术、尺度效应及其产业化应用，同时还包括个性化不对称制剂或梯度制剂、3D打印新型制剂、黏膜给药制剂的研究与开发。主持多项国家自然科学基金、浙江省自然科学基金及企业委托横向项目，作为主要参与人完成加拿大国家自然科学与工程基金（NSERC）、加拿大安省卓越基金（OCE）等项目。在Acta Biomaterialia, Chemical Engineering Journal, International Journal of Pharmaceutics, Powder Technology 等药剂领域TOP期刊上发表高水平学术论文40多篇，授权美国专利1项，中国发明专利6项，参与编写英国皇家化学会RSC学术专著1部。作为核心成员申报并获批100mg阿司匹林肠溶片生产批件。

主要研究领域或方向：

1. 微纳递药颗粒的设计构建关键技术及尺度效应

2. 分子马达用于高效药物递送入脑/入肺

3. 干粉吸入制剂用于肺部药物递送

4. 制剂新工艺及新技术（包衣技术、3D打印）

主讲（辅讲）课程

本科生课程：药用高分子材料学、专业英语C、药物制剂工程等

留学生课程：生物药剂学与药物动力学

研究生课程：物理药剂学、高等药剂学

• 指导学生获奖

第八届全国大学生生命科学竞赛（创新创业类）二等奖（2023年，许庭烽&夏怡，本科生）

浙江省第十八届“挑战杯”大学生课外学术科技作品竞赛 银奖（2023年，许庭烽&夏怡，本科生）

浙江省专业学位研究生优秀实践成果（2023，陈佳乐，硕士）

浙江工业大学优秀硕士论文（2023，刘懿雯，硕士）

省级优秀毕业生（2023，陈佳乐，硕士）

校级优秀毕业生（2023，刘懿雯，硕士）

校级优秀毕业生（2022年，钟葳珍，硕士）

校级优秀毕业生（2020年，袁凤，硕士）

浙江工业大学健行荣誉生（2021年，陈馨怡，本科生）

• 本科生一作发表论文

1）Tingfeng Xu（2021级本科生）, Huijie Li, Yi Xia（2021级本科生）, Sheng Ding, Qingliang Yang* and Gensheng Yang*. Three-Dimensional-Printed Oral Films Based on LCD: Influence Factors of the Film Printability and Received Qualities. Pharmaceutics, 2023, 15(3): 758.

2）Mengning He（2017级本科生）, Lingmeng Zhu（2017级本科生）, Ni Yang, Huijie Li, Qingliang Yang*. Recent advances of oral film as platform for drug delivery, International Journal of Pharmaceutics, 2021, 604:120759.

3）陈馨怡（2017级本科生），袁凤，史楷岐，杨根生，杨庆良*. 渗透泵药物控释制剂包衣工艺研究进展, 中国药学杂志, 2021, 56(23): 41-46

4）陈馨怡（2017级本科生），袁凤，史楷岐，杨根生，杨庆良*. 静电干法包衣构建复方丹参片防潮包衣膜, 中草药, 2020, 51(20): 5148-5153

• 本人获奖

校级优秀班主任（2019年）

校级优秀本科生导师（2020年）

1. 光质双驱动马达机器人突破多重生物屏障强化经鼻入脑药物传输，国家自然科学基金面上项目22478355，主持

2. 多尺度下超细粉静电沉积构建渗透泵包衣膜机制研究，国家自然科学基金青年项目21808206, 主持

3. 靶点特异性程序化响应生物分子马达递送系统构建及机制研究，国家自然科学基金面上项目22078297，排名第二

4. 3D打印仿生微流控经皮递药系统研究，浙江省自然科学基金一般项目LY20B060007, 主持

5. 干粉吸入制剂药效学研究与技术开发，企业横向，200万元，主持

6. 中药/中成药干粉包衣技术，企业横向，50万元，主持

代表性成果：

1. Qingliang Yang †, Xuhui Zhou †, Bang Lou, Ning Zheng, Jiale Chen, Gensheng Yang*. An FOF1-ATPase Motor-Embedded Chromatophore as a Nanorobot for Overcoming Biological Barriers and Targeting Acidic Tumor Sites. Acta Biomaterialia, 2024, 179: 207-219. DOI: 10.1016/j.actbio.2024.03.016.

2. Yiwen Liu†, Ruirui Liu†, Qingliang Yang*, Gensheng Yang*, DES/O microemulsion for solubilizing and delivering curcumin via the nasal administration to treat acute asthma, International Journal of Pharmaceutics, 2024, 124900. doi.org/10.1016/j.ijpharm.2024.124900.

3. Sheng Ding†, Shaoqin He†, Lian Shen, Qingliang Yang*, Gensheng Yang*. An instructional design strategy for optimization of GelMA hydrogels material properties, European Polymer Journal, 2024, 218:113336. doi.org/10.1016/j.eurpolymj.2024.113336.

4. Jiale Chen, Qingliang Yang*, Jinming Liu, Mengya Jin, Shaoqin He, Xuhui Zhou, Hang Zhou, Jie Dong, Gensheng Yang, Jesse Zhu*. Understanding the correlations between tablet flow dynamics and coating uniformity in a pan coater: Experiments and simulations. Chemical Engineering Journal, 2023, 471,144392. doi.org/10.1016/j.cej.2023.144392.

5. Siying Pan, Sheng Ding, Xuhui Zhou, Ning Zheng, Meng Zheng, Juan Wang, Qingliang Yang^*, Gensheng Yang^*. 3D-Printed Dosage Forms for Oral Administration: A Review. Drug Delivery and Translational Research, 2023, https://doi.org/10.1007/s13346-023-01414-8.

6. Yujing Wu †, Bang Lou †, Ning Zheng, Xuhui Zhou, Ying Gao, Weiyong Hong*, Qingliang Yang* and Gensheng Yang*. FOF1-ATPase Motor-Embedded Chromatophore as Drug Delivery System: Extraction, Cargo Loading Ability and Mucus Penetration Ability. Pharmaceutics, 2023, 15(6): 1681. doi.org/10.3390/pharmaceutics15061681.

7. Qingliang Yang, Weizhen Zhong, Yiwen Liu, Runlin Hou, Yujing Wu, Qinying Yan, Gensheng Yang*. 3D-printed morphology-customized microneedles: Understanding the correlation between their morphologies and the received qualities, International Journal of Pharmaceutics, 2023, 638,122873. doi.org/10.1016/j.ijpharm.2023.122873.

8. Tingfeng Xu †, Huijie Li †, Yi Xia, Sheng Ding, Qingliang Yang* and Gensheng Yang*. Three-Dimensional-Printed Oral Films Based on LCD: Influence Factors of the Film Printability and Received Qualities. Pharmaceutics, 2023, 15(3): 758.

9. Qingliang Yang, Jiale Chen, Xuhui Zhou, Hang Zhou, Gensheng Yang*, Jesse Zhu*,Modeling of inter-tablet coating uniformity of electrostatic dry powder coating by discrete element method. Powder Technology, 2022, 411, 117929. doi.org/10.1016/j.powtec.2022.117929.

10. Yiwen Liu, Yujing Wu, Jinming Liu, Wenxi Wang, Qingliang Yang*, Gensheng Yang*. Deep eutectic solvents: Recent advances in fabrication approaches and pharmaceutical applications. International Journal of Pharmaceutics, 2022, 622:121811. doi.org/10.1016/j.ijpharm.2022.121811.

11. Qingliang Yang, Feng Yuan, Jiale Chen, Hang Zhou, Gensheng Yang*, Jesse Zhu*., Delayed sustained drug release from electrostatic powder coated tablets with ultrafine polymer blends. Powder Technology, 2021, 394, 496-503. doi.org/10.1016/j.powtec.2021.08.088.

12. Mengning He, Lingmeng Zhu, Ni Yang, Huijie Li, Qingliang Yang*. Recent advances of oral film as platform for drug delivery. International Journal of Pharmaceutics, 2021, 604:120759. doi.org/10.1016/j.ijpharm.2021.120759

13. Lei Xu, Qingliang Yang *, Wei Qiang, Huijie Li, Weizhen Zhong, Siying Pan, Gensheng Yang *, Hydrophilic excipient-independent drug release from SLA-printed pellets, Pharmaceutics, 2021, 13, 1717.

14. Qingliang Yang, Ying Gao, Lei Xu, Weiyong Hong, Yuanbin She, Gensheng Yang*. Enzyme-driven micro/nanomotors: Recent advances and biomedical applications, International Journal of Biological Macromolecules. 2021,167: 457-469. doi.org/10.1016/j.ijbiomac.2020.11.215

15. Qingliang Yang, Weizhen Zhong, Lei Xu, Huijie Li, Qinying Yan, Yuanbin She, Gensheng Yang*. Recent progress of 3D-printed microneedles for transdermal drug delivery, International Journal of Pharmaceutics, 2021, 593,120106. doi.org/10.1016/j.ijpharm.2020.120106

16. Qingliang Yang, Lei Xu, Weizhen Zhong, Yan Yang, Kaiqi Shi, Gensheng Yang*. Recent Advances in Motion Control of Micro/Nanomotors. Advanced Intelligent Systems, 2020, 2(8), 2000049. doi.org/10.1002/aisy.202000049

17. Qingliang Yang, Feng Yuan, Lei Xu, Weizhen Zhong, Yan Yang, Kaiqi Shi, Gensheng Yang*, Jesse Zhu*., Moisture barrier films for herbal medicines fabricated by electrostatic dry coating with ultrafine powders. Powder Technology, 2020, 366, 701-708. https://doi.org/10.1016/j.powtec.2020.03.023

18. Qingliang Yang, Feng Yuan, Yingliang Ma, Kaiqi Shi, Gensheng Yang, Jesse Zhu*. Electrostatic powder coated osmotic pump tablets: influence factors of coating powder adhesion and film formation, Powder Technology, 2020, 360: 444-451. https://doi.org/10.1016/j.powtec.2019.10.084

19. Qingliang Yang, Feng Yuan, Lei Xu, Qinying Yan, Yan Yang, Danjun Wu, Fangyuan Guo, Gensheng Yang*. An update of moisture barrier coating for drug delivery, Pharmaceutics, 2019, 11(9), 436. https://doi:10.3390/pharmaceutics11090436

20. Qingliang Yang, Yingliang Ma, Kaiqi Shi, Gensheng Yang, Jesse Zhu. “Electrostatic coated controlled porosity osmotic pump with ultrafine powders”, Powder Technology, 2018, 333: 71-77. https://doi.org/10.1016/j.powtec.2018.04.009

21. Qingliang Yang, Yingliang Ma, Jesse Zhu. “Dry powder coated osmotic drug delivery system”, European Journal of Pharmaceutical Sciences, 2018, 111: 383-392. http://dx.doi.org/10.1016/j.ejps.2017.10.001

22. Qingliang Yang, Yingliang Ma, Jesse Zhu, Kwok Chow, Kaiqi Shi. “An update on electrostatic powder coating for pharmaceuticals”, Particuology, 2017, 31: 1-7. http://dx.doi.org/10.1016/j.partic.2016.10.001

23. Qingliang Yang, Yingliang Ma, Jesse Zhu. “Sustained drug release from electrostatic powder coated tablets with ultrafine ethylcellulose powders”, Advanced Powder Technology, 2016, 27: 2145-2152. http://dx.doi.org/10.1016/j.apt.2016.07.027

24. Qingliang Yang, Yingliang Ma, Jesse Zhu. “Applying a novel electrostatic dry powder coating technology to pellets”, European Journal of Pharmaceutics and Biopharmaceutics, 2015, 97: 118-124. http://dx.doi.org/10.1016/j.ejpb.2015.10.006

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