范永仙

受教育经历

· 2007/09-2014/6   浙江工业大学，生物与环境工程学院，博士（生物化工）

· 1999/09-2002/06  浙江工业大学，生物与环境工程学院，硕士（生物化工）

· 1994/09-1998/06  浙江工业大学，轻工系，学士（生物化工）

研究工作经历

· 2004/08-至今  浙江工业大学，化学工程学院，助研、副研究员

· 2002/07-2004/08 浙江省农科院，植保所，助研

主持浙江省重点研发项目“基于绿色工艺的高附加值新型专用化学品开发及产业化-酪氨酸酶抑制剂α-熊果苷生物催化绿色合成工艺研究及产业化”(2019C01085)（245万元）、浙江省科技厅公益性项目“顺丁烯二酰亚胺类化合物的制备及其生物活性研究”（2015C34003）（20万元）、浙江省自然科学基金“蒙脱土负载金属卟啉仿生催化剂的设计制备及催化氯丙烯环氧化的研究” （8万元）、和企业横向 “施比灵止痒消炎水和同类产品的主要成分含量等比较研究”（15万元）、“酪氨酸酶抑制剂α-熊果苷生物催化绿色合成工艺研究及产业化”（30万元）和“酶法制备柚皮苷单糖苷研发”（15万元）。参加国家自然科学基金项目、省重大专项、企业横向项目等20余项。

指导学生：利用废电池制备多形态MnO2催化降解亚甲基蓝废液，第四届全国大学生化学实验创新设计竞赛华东区赛一等奖

指导学生：利用废弃蛋壳制备葡萄糖酸钙及获得钙制品，第三届全国大学生化学实验创新设计竞赛华东区赛二等奖

课程名称：《基础化学实验（I）A1》和《基础化学实验（I）A2》；《基础化学实验（II）B1》，《基础化学实验（II）B2》

主要论著

· Fan Yongxian, Lu Yuele, Chen Xiaolong, et al. Anti-leishmanial and cytotoxic activities of a series of maleimides: synthesis, biological evaluation and structure-activity relationship. Molecules, 23, 2878, 2018.

· Yongxian Fan, Yang Yu, Xiaoqing Jia, Xiaolong Chen*, Yinchu Shen.  Cloning, expression and medium optimization of validamycin glycosyltransferase from Streptomyces hygroscopicus var. jinggangensis for the biotransformation of validoxylamine A to produce validamycin A using free resting cells.  Bioresource Technology, 131: 13-20, 2013.

· Fan Yongxian; Xie Zhangming; Zhang Huawei; Qian Junqing. Kinetic resolution of both 1-phenylethanol enantiomers produced by hydrolysis of 1-phenylethyl acetate with Candida antarctica lipase b in different solvent systems.  Kinetics and Catalysis, 52: 1-6, 2011.

· Fan Yongxian; Qian Junqing.  Lipase catalysis in ionic liquids/supercritical carbon dioxide and its applications. Journal of Molecular Catalysis B-Enzymatic, 66: 1-7, 2010.

· Fan Yongxian; Zhou Chunhui; Zhu Xiaohong.  Selective catalysis of lactic Acid to produce commodity chemicals.  Catalysis Reviews-Science and Engineering, 51: 293-324, 2009.

· Fan Yongxian; Qian Junqing.  Screening, identifying and medium optimization of a lipase-producing filamentous fungus from soil for high chiral resolution of 1-phenylethanol.  African Journal of Microbiology Research, 7: 4235-4243, 2013.

· Yongxian Fan, Yuele Lu, Liwei Zhang, Xiaolong Chen*, Yinchu Shen.  Enhancing NADPH regeneration and increasing hydroxylation efficiency with P450 monooxygenase through strengthening expression of glucose-6-phosphate dehydrogenase in industrial filamentous fungi.  Biocatalysis and Agricultural Biotechnology, 11,  307-311, 2017.

· Chen Xiaolong，Lu Yuele，Fan Yongxian，Shen Yinchu. Validamycin and Its Derivatives, 2017.5, Elsevier.（英文专著）

· Chen Xiaolong; Fan Yongxian; Zheng Yuguo; Shen Yinchu.  Properties and production of valienamine and its related analogues.  Chemical Reviews, 103: 1955-1977, 2003.

· Rui Guo, Yongxian Fan, Xiaolong Chen*, Yinchu Shen.  Chiral resolution of racemic p-methylsulfonylphenyl serine ethyl ester with lipases: The mechanism of side reaction and its suppression.  Journal of Agricultural and Food Chemistry, 61: 152-166, 2013.

· Zhenzhong Shen, Yongxian Fan, Fuge Li, Xiaolong Chen*, Yinchu Shen. Synthesis of a series of N-substituted dimethylmaleimides and their antifungal activities against Sclerotinia sclerotiorum.  Journal of Pest Science, 86, 363-360, 2013.

· Wei Li, Yongxian Fan, Zhenzhong Shen, Xiaolong Chen, Yinchu Shen. Antifungal activity of simple compounds with maleic anhydride or dimethylmaleimide structure against Botrytis cinerea.  Journal of Pesticide Science, 37: 1-5, 2012.

· 陆跃乐, 戴松俊, 杨闯, 周瑶瑶, 包莹玲, 范永仙*. 手性农药己唑醇和腈菌唑对黄酒酿造微生物酶活性的影响. 农药学学报，19：341-346，2017.

· 沈雪亮; 范永仙; 汪钊.  外循环气升式生物反应器中酯酶生产及应用.  高校化工学报，44：320-325，2010.

· Xie, H. L.; Fan, Y. X.; Zhou, C. H.; Du, Z. X.; Min, E. Z.; Ge, Z. H.; Li, X. N.  A review on heterogeneous solid catalysts and related catalytic mechanisms for epoxidation of olefins with H₂O₂. Chemical and Biochemical Engineering Quarterly, 22: 25-39, 2008.

专利

l 一种3,4-二氯顺丁烯二酰亚胺化合物及其制备与应用  1/5 ZL201310047509.7  发明专利

l G6PDH基因在提高黑根霉对甾体C11α-羟基化能力中的应用及菌株 2/5  ZL201310505530.7 发明专利

l  N-(3,5-二氯苯基)-3,4-二氯-顺丁烯二酰亚胺在抗真菌感染中的应用 2/5  ZL201310462766.7 发明专利

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