近五年发表的代表性论文:
(1) Chen PQ, Zong JY, Duan ZJ, Luo HS, Fan YL, Wang YJ*, Chu C*(2026). A novel tyrosinase immobilization strategy based on hydrophilic multivariate mesoporous metal-organic frameworks for ligand fishing of tyrosinase inhibitors from herbal medicines. International Journal of Biological Macromolecules, 364: 152270.
(2) Hu WX, Zong JY, Gong JJ, Xue R, Lv YB, Liu B, Dai WT, Wang YJ*, Chu C*(2026). Lipase Immobilization via Dynamic Defect-Engineered ZIF-8: A Bioactivity-Enhanced Platform for High-Efficiency Screening of Herbal Lipase Inhibitors. International Journal of Biological Macromolecules, 335:169264.
(3) Chen PQ, Fan YL, Ma XX, Li JJ, Tong SQ, Chu C* (2026). An enhanced chemical profiling characterization strategy integrating off-line two-dimensional counter-current chromatography × UHPLC–MS/MS and feature-based molecular networking: Comprehensive characterization of the fibrous root of Bletilla striata as a case study. Journal of Chromatography B, 1277:125050.
(4) Zhang XD, Liu B, Zou YF, Hu WX, Lv YB, Li CY, Quan SH, Tong SQ, Đoàn Q , Zhao J, Peng X, Chu C*(2026). An efficient strategy for the rapid exploration of lipase inhibitors derived from the Lindera aggregate leaves by utilizing hybrid lipase catalytic zeolitic imidazolate framework reactor combined with HPLC-Q-TOF-MS/MS and molecular docking techniques. Food & Medicine Homology. https://doi.org/10.26599/FMH.2026.942009
(5) Lv YB, Xu N*, Chu C*(2025). Authentication of Linderae Radix through plant metabolomics coupled with a machine learning-enhanced in situ hyperspectral imaging approach. Journal of Pharmaceutical Analysis, online, in press.
(6) Liu B, Zhang WY, Chen ZW, Ma XX , Li JJ , Li CY, Wang P, Chu C * (2025). Comprehensive review of botany, phytochemistry and pharmacology of quality control of Succus Bambusae. Industrial Crops and Products, 229, 120979.
(7) Liu BR, Hu WX, Li HJ, Yan JK, Zhang XT, Chu C*, Zhang YS*(2025). Magnetic beads-based ligand fishing for rapid screening of dietary α-glucosidase inhibitory ligands from the rhizome of Alpinia officinarum Hance combined with molecular docking. JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE, 105, 9, 4927-4940
(8) Li W, Cheng Y, Gao Y, Qin Y, Zhao B, Tong S, Chu C*, Lin H*. (2025). A new dual-mode enrichment strategy using MSPD and dynamic pH junction-sweeping MEKC for analyzing flavonoids and organic acids in complex matrices. Microchemical Journal, 115680.
(9) Xue R, Qin Y, Gao W, Zang Y, Lv Y, Cheng Y, Sun W, Chu, C*. (2025). Eco‐Friendly Capillary Electrophoresis for Enhanced Detection of Hydrophobic Flavonoids in Tangerine Peel Tea via Borate Complexation and Micellar Stacking. Phytochemical Analysis. 36(7): 2011-2021.
(10)Xu WF, Li B, Ge ZH, Li L , He XLS, Chen XN , Chu C*, Lv GY*, Chen SH*(2025). Shoutai pill exhibits anti-miscarriage efficacy through tripartite modulation of gut microbiota, systemic metabolism, and maternal-fetal immunity: A multi-omics analysis. Phytomedicine, 145, 156991.
(11)Zhang YP, Dong SM, Li ZY, Zhou CL, Qiao YL, Xu WF, Li B, Chu C*, Lv GY*, Chen S H*(2025). Shoutai Pill synergistically inhibits internal reproductive organ apoptosis: coordinated EGFR/PI3K/AKT modulation in primary ovarian insufficiency. Journal of Ethnopharmacology, 120247.
(12)Chu C*, Lv YB, Yao XD, Ye HW, Li CY, Peng X, Gao ZW, Mao KJ*(2024). Revealing quality chemicals of Tetrastigma hemsleyanum roots in different geographical origins using untargeted metabolomics and random-forest based spectrum-effect analysis. Food Chemistry, 449,139207.
(13)Liu B, Li CY, Dai JJ, Xu J, Ye HW, Gong JJ, Zhang WY, Zeng YQ*, Chu C*(2024). Revealing chemical differences and pharmacological activities of Succus Bambusae prepared by different methods using comparative metabolomics integrated network pharmacology and spectrum-effect relationship approach. Industrial Crops and Products, 222,119611.
(14)Qin YX, Gao W, Xu J, Ping L, Tong SQ, Liu B, Chu C*(2024). A simple and green offline-online capillary electrophoresis stacking strategy for the simultaneous determination of hydrophobic compounds in complicated samples using sodium dodecyl sulfate as the solubilizer and pseudophase. Anal. Chim. Acta. 1311,342736.
(15)Xu J, Ye HW, Zhang XD, Lv YB, Tong SQ, Liu B, Ou ZM*, Chu C*(2024). Comparative study on metabolite variations of two rose teas by plant metabolomics and revealing their skin-whitening candidates by spectrum–effect relationship analysis. Phytochem Anal. 1-12.
(16)Hu WX, Li JY, Zhang XD, Lv YB, Ye HW, Li CY, Liu EH, Chu C*(2024). Integrating sodium cholate-modified MOF hybrid lipase and solubilization of hydrophobic candidates into a step for liganding fishing lipase inhibitors from Nelumbinis Folium. J. Pharm. Biomed. Anal. 251, 116430.
代表性专利:
(1) 楚楚,李家旭,李陈玥,吕洋彬,彭昕,王平。一种具有美白活性的白及须根提取物及其应用。ZL 2022 1 1612371.6,2025-04-04
(2) 楚楚,臧雅萍,陈素红,李家旭,李波。盐析辅助液-液萃取与毛细管电泳在线富集法结合测定蒽醌类成分的方法。ZL202210802552.9,2024-5-30
(3) 楚楚,杨斐。一种基于植物代谢组学和谱效关系的决明子质量评价方法 。ZL202210344952.X, 2024-03-26
(4) 楚楚,连琳敏,臧雅萍,童胜强,陈素红,王平,颜继忠。一种基于MSPD联用EKS-CZE测定石蒜科生物碱含量的方法。ZL202110634898.8,2022-08-30
(5) 楚楚,刘彩婧,连琳敏,杨斐,童胜强,颜继忠。一种基于MSPD提取联合FESI-MCDS-MEKC在线测定呋喃香豆素含量的方法。ZL202011146591.5,2022-08-30
(6) 楚楚,连琳敏,臧雅萍,童胜强,陈素红,王平,颜继忠。一种基于离子液体涂层的FLM-EKS-CZE在线富集测定有机酸含量的方法。ZL202110634894.X, 2022-07-01
(7) 楚楚,刘彩婧,连琳敏,李璟,颜继忠。一种基于FESI-MCDS-MEKC检测中性物质含量的方法。ZL201911031010.0,2022-07-01
(8) 楚楚,毛惠。一种同时测定木香顺气丸中木脂素类成分和萜类成分含量的方法。ZL202011593682.3, 2022-04-19
(9) 楚楚,王珊,江璐依,唐谊平,颜继忠。一种蜂蜜中黄酮类成分的含量测定方法。ZL201910108126.3, 2021-10-15
(10)楚楚,刘彩婧,连琳敏,李璟,颜继忠。一种基于FASS-MCDS 在线富集测定生物碱含量的方法。ZL201910340784.5,2021-06-01
(11)楚楚,王珊,颜继忠。一种温郁金中倍半萜成分的提取富集方法。ZL201910078215.8, 2021-06-29
(12)楚楚,江璐依,唐谊平,颜继忠.一种测定蒽醌类成分含量的方法。ZL201810947817.8, 2021-02-02
(13)楚楚,魏蒙蒙,刘彩婧,颜继忠。基于FESI-sweeping-MSS联用在线富集测定痕量有机阴离子的方法。ZL201810118606.3, 2020-02-21
(14)楚楚,李清,魏蒙蒙,王珊,颜继忠。一种同时测定中成药中黄曲霉素B1,B2含量的方法。ZL201710123086.0, 2019-10-29
(15)楚楚,郑丽琼,魏蒙蒙,颜继忠。一种五味子中木脂素类有效成分的提取检测方法。ZL201610929146.3, 2019-7-26
(16)楚楚,李行诺,颜继忠,章诗迪,宋敏。一种提取制备苯甲酰芍药苷和苯甲酰芍药内酯苷的方法,ZL201410144187.2, 2016-04-13
(17)楚楚。一种从生脉方中分离制备5-羟甲基糠醛的方法,ZL201410456332.0, 2016-09-14
(18)楚楚,颜继忠,童胜强,章诗迪。一种五味子中木脂素单体的提取分离制备方法,ZL201310429192.3, 2015-10-28
(19)楚楚,颜继忠,章诗迪,童胜强,李行诺。五味子中木脂素单体的提取分离制备方法,ZL201310431854.0, 2014-4-22
(20)彭昕,楚楚,邹艳芳,童胜强。一种提取分离乌药叶中黄酮类成分的方法。ZL 202111330523.9,2023-03-21.
科研获奖:
童胜强,颜继忠,单伟光,楚楚,多样化洗脱逆流色谱制备性分离手性化合物,第二届浙江省自然科学学术奖,三等奖,2012.
童胜强,颜继忠,程冬萍,楚楚,李行诺,浙江省药学会科学技术奖,二等奖,2017.