代文婷

代文婷，女，博士，山西临汾人，特聘研究员，硕士生导师。美国化学协会、美国奶业协会会员等。2018年浙江大学获得营养学博士学位，继而前往美国希望之城国家医学研究中心开展了5年的医学博士后研究，主要围绕线粒体开展了癌症代谢疾病调控研究，提出了线粒体动力学变化及线粒体代谢失调对癌症代谢重编程的影响及其与癌症发生、迁移的关联调控机制，为癌症控制的精准靶向治疗提供了新思路。迄今为止，已发表SCI收录论文30篇，五年影响因子IF₅累积超200，包括Science、Nature、Nature Communications, Cell Reports、Journal of Clinical Investigation、Progress in Lipid Research、British Journal of Cancer、Cellular and Molecular Life Sciences、Science of the Total Environment、Frontiers in Endocrinology、Journal of Agricultural and Food Chemistry、Journal of Dairy Science、British Journal of Nutrition等国际权威学术期刊，总引用次数达1080次，Google Scholar H10指数18。

受邀参加2024 第一届生物计算与医学国际会议（中国 杭州）、2023 Biology of Cancer Meeting (USA)、The 6^th Mitochondrial Symposium (USA)、American Chemical Society (ACS) National Meeting、ADSA-ASAS Joint Annual Meeting、American Annual RSO Conference等国际学术会议，做国际会议口头报告6次、墙报2次。

2025年入选浙江省海外高层次引才计划（青年人才项目），入选浙江工业大学药学院国家级C类人才培育计划，获得吉林省科技进步二等奖1项（第四完成人），浙江大学优秀毕业生等科技奖励和荣誉称号，目前主持省部级项目2项（浙江省青年基金项目和浙江省教育厅项目各1项）和参与国家自然科学基金面上基金1项（第二完成人）。

目前主要从事疾病药理学研究和新药研发相关研究工作，欢迎大家加入我们研究团队。

学习与工作经历：

2024 - 至今  浙江工业大学，药学院，特聘研究员

2018 - 2024      美国希望之城国家医学研究中心，代谢病研究所，博士后

2015 - 2018      浙江大学，动物营养学专业，博士

Google scholar个人主页：https://scholar.google.com/citations?user=hShlOFwAAAAJ&hl=en

Researchgate个人主页：https://www.researchgate.net/profile/Wenting-Dai-3

主讲《药剂学》全英文 本科生课程;

辅讲《人体生理学》全英文和中文 本科生课程。

1.薛斌，代文婷， 王亚军. 第七届全国药学专业学位优秀教学案例. 2024.

2.薛斌，代文婷，完彦军，陶益，饶国武，欧志敏，楚楚，王亚军. 校级教学改革项目——人工智能驱动的生物制药新工科教学改革与人才培养模式创新. 2025.

1. 浙江省自然科学基金青年项目（LQN25H160055），202501至202612, 10万，在研，主持。

2. 浙江省教育厅一般项目（KYY-ZX-20240431）, 20240901至20260831,  1万元，在研，主持。

3. 浙江省教育厅一般项目（KYY-ZX-20240444），20240901至20260831,  1万元，在研，参与。

4. 国家自然科学基金面上项目 （No. 31672447）， 2017-01-01 至 2020-12-31,  65万元，主要完成人（第二位），参与。

发表论文

2025

1. Miao MA1, Wu XQ1, Yuan Y,  Wang YJ, Dai WT*. Biochanin A as a potential agent in the disease therapy via mitochondria-mediated mechanisms. Biomedicine & pharmacotherapy. 2025 Sep:190:118363. (IF5=7.7; JCR：1区)（独立通讯）

2. Dai WT*, Xue B, Yuan Y, and Liu HY*. ZDHHC9 mediates SMURF2 palmitoylation to promote lipid synthesis. Cell Investigation. 2025 1 (2), 100015（独立第一兼共同通讯）

3. Jaya Gautam #, Jianhan Wu #, James S V Lally #, Jamie D McNicol, Russta Fayyazi , Elham Ahmadi, Daniela Carmen Oniciu, Spencer Heaton, Roger S Newton, Sonia Reha, Dipankar Bhattacharya, Fiorella Di Pastena, Binh Nguyen, Celina M Valvano, Logan K Townsend, Suhrid Banskota, Battsetseg Batchuluun, Maria Joy Therese Jabile, Alice Payne, Junfeng Lu, Eric M Desjardins, Naoto Kubota, Evangelia E Tsakiridis, Bejal Mistry, Alex Aganostopoulos, Vanessa Houde, Ann Dansercoer, Koen H G Verschueren, Savvas N Savvides, Joanne A Hammill, Ksenia Bezverbnaya, Paola Muti, Theodoros Tsakiridis, Wenting Dai, Lei Jiang, Yujin Hoshida, Mark Larché, Jonathan L Bramson , Scott L Friedman, Kenneth Verstraete, Dongdong Wang , Gregory R Steinberg*. ACLY inhibition promotes tumour immunity and suppresses liver cancer. Nature. 2025 Sep;645(8080):507-517. (IF5=55.0；JCR：1区) (32/42, 共同作者)

 4. Wang G#, Li GY#, Song AY, Zhao YT, Yu JY, Wang YF, Dai WT, Salas M, Qin HJ, Medrano L, Dow J, Li AM, Armstrong B, Fueger PT, Yu H, Zhu Y, Shao ML, Wu XW, Jiang L, Campisi J, Yang X*, Wang QA*. Distinct adipose progenitor cells emerging with age drive active adipogenesis. Science 2025 April 25; 388 (6745): eadj0430. (IF5=50.3；JCR：1区) （共同作者，6/23）

2024

1. Dai WT#, Han BQ#, Sun YL, Hou PF, Wang C, Li WN, and Liu HY*. Integrated Transcriptomic Analyses of Liver and Mammary Gland Tissues Reveals the Regulatory Mechanism Underlying Dairy Goats at Late Lactation When Feeding Rumen-Protected Lysine. International Journal of Molecular Sciences. 2024 Oct 23;25(21):11376. (IF5=5.6; JCR：1区) （共同第一）

2023

1. Dai WT*, Wang ZC, Wang G, Wang AQ, DeBerardinis RJ, Jiang L*. FASN-deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress. Cell Reports. 2023 Aug 29;42(8):112971. (IF5=9.9；JCR：1区) （独立第一兼共同通讯）

 2. Liu HY*, Wei XS, Dai WT, Xu LB, Wang C, Liu JX. The functional and regulatory entities underlying free and peptide-bound amino acid transporters in the bovine mammary gland. JDS Communications. 2023 Feb 24;4(3):235-239. (IF5=4.0；JCR：1区) （共同作者，3/6）

2022

1. Dai WT, Wang ZC, Wang Q, Chan D, Jiang L*. Metabolic reprogramming in the OPA1-deficient cells. Cellular and Molecular Life Sciences. 2022 Sep 14;79(10):517. (IF5=8.7； JCR：1区) （独立第一兼共同通讯）

 2. Hou PF#, Dai WT#, Jin YS, Zhao FQ, Liu JX, Liu HY*. Maternal exposure to di-2-ethylhexyl phthalate (DEHP) depresses lactation capacity in mice. Science of The Total Environment. 2022 Sep 1;837:155813. (共同一作；IF5=9.6；JCR：1区) （共同第一）

 3. Dai WT, White RR, Liu JX, Liu HY*. Organelles coordinate milk production and secretion during lactation: Insights into mammary pathologies. Progress in Lipid Research. 2022 Mar 8;86:101159. (IF5=16.1；JCR：1区) （独立第一）

 4. Merz K, Hwang J, Zhou C, Veluthakal R, McCown E, Hamilton A, Oh E, Dai WT, Fueger P, Jiang L, Huss J, Thurmond D*. STX4 enrichment in skeletal muscle remediates peripheral insulin 2 resistance and alters mitochondrial dynamics via Drp1. Nature Communications. 2022 Jan 20;13(1):424. (IF5=17.0；JCR：1区) （共同作者，8/12）

2020

1. Dai WT, Wang G, Chwa J, Oh ME, Abeywardana T, Yang Y, Wang Q, Jiang L*. Mitochondrial division inhibitor (mdivi-1) decreases oxidative metabolism in cancer. British Journal of Cancer. 2020 Apr;122(9):1288-1297. (IF5=8.4；JCR：1区) （独立第一）

 2. Dai WT, Zhao FQ, Liu JX, Liu HY*. ASCT2 Is Involved in SARS-Mediated β-Casein Synthesis of Bovine Mammary Epithelial Cells with Methionine Supply. Journal of Agricultural and Food Chemistry. 2020 Nov 18;68(46):13038-13045. (IF5=6.3；JCR：1区) （独立第一）

 3. Dai WT, Zhao FQ, Liu JX, Liu HY*. Seryl-tRNA synthetase is involved in methionine stimulation of β-casein synthesis in bovine mammary epithelial cells. British Journal of Nutrition. 2020 Mar 14;123(5):489-498. (IF5=4.0；他引次数：11；JCR：1区) （独立第一）

 4. Song AY, Dai WT, Jang MJ, Medrano L, Li Z, Zhao H, Shao M, Tan J, Li A, Ning T, Miller MM, Armstrong B, Huss JM, Zhu Y, Liu Y, Gradinaru V, Wu X, Jiang L, Scherer PE, Wang QA*. Low- and high-thermogenic brown adipocyte subpopulations coexist in murine adipose tissue. Journal of Clinical Investigation. 2020 Jan 2;130(1):247-257. (IF5=16.7；JCR：1区) （共同作者，2/20）

2019

1. Dai WT, Jiang L*. Dysregulated Mitochondrial Dynamics and Metabolism in Obesity, Diabetes, and Cancer. Frontiers in endocrinology (Lausanne). 2019 Sep 3;10:570. (IF5=5.9；JCR：2区) （独立第一）

2018

1. Dai WT, White RR, Liu JX, Liu HY*. Seryl-tRNA synthetase-mediated essential amino acids regulate β-casein synthesis via cell proliferation and mammalian target of rapamycin (mTOR) signaling pathway in bovine mammary epithelial cells. Journal of Dairy Sciences. 2018 Nov;101(11):10456-10468. (IF5=4.2；JCR：1区) （独立第一）

 2. Dai WT, Wang QJ, Zhao FQ, Liu JX, Liu HY*. Understanding the regulatory mechanisms of milk production using integrative transcriptomic and proteomic analyses: improving inefficient utilization of crop by-products as forage in dairy industry. BMC Genomics. 2018 May 29;19(1):403. (IF5=4.7；JCR：2区) （独立第一）

 3. Dai WT, Zou YX, White RR, Liu JX, Liu HY*. Transcriptomic profiles of the bovine mammary gland during lactation and the dry period. Functional & Integrative Genomics. 2018 Mar;18(2):125-140. (IF5=3.3；JCR：2区) （独立第一）

 4. Chen Q, Dai WT, Sun YL, Zhao FQ, Liu JX, Liu HY*. Methionine Partially Replaced by Methionyl- Methionine Dipeptide Improves Reproductive Performance over Methionine Alone in Methionine-Deficient Mice. Nutrients. 2018 Sep 1;10(9): 1190. (IF5=6.6；JCR：1区) （共同作者，2/6）

 5. Luo CC1, Zhao SG1, Dai WT, Zheng N, Wang JQ. Proteomic Analysis of Lysosomal Membrane Proteins in Bovine Mammary Epithelial Cells Illuminates Potential Novel Lysosome Functions in Lactation. Journal of Agricultural and Food Chemistry. 2018 Dec 12;66(49):13041-13049. (IF5=6.6；JCR：2区) （共同作者，2/5）

 6. Luo CC1, Zhao SG1, Dai WT, Zheng N, Wang JQ. Proteomic analyses reveal GNG12 regulates cell growth and casein synthesis by activating the Leu-mediated mTORC1 signaling pathway. BBA- Proteins and Proteomics. 2018 Nov;1866(11):1092-1101. (IF5=2.9；JCR：2区) （共同作者，3/5）

 2017

1. Dai WT, Chen Q, Wang QJ, White RR, Liu JX, Liu HY*. Complementary transcriptomic and proteomic analyses reveal regulatory mechanisms of milk protein production in dairy cows consuming different forages. Scientific Reports. 2017 Mar 14;7: 44234. (IF5=4.9；JCR：2区) （独立第一）

 2. Dai WT, Wang QJ, Zou YX, White RR, Liu JX, Liu HY*. Short communication: Comparative proteomic analysis of the lactating and nonlactating bovine mammary gland. Journal of Dairy Sciences. 2017 Jul;100(7):5928-5935. (IF5=4.2；JCR：1区) （独立第一）

2016

1. Hu H, Zheng N, Gao HN, Dai WT, Zhang YD, Li S, Wang JQ. Immortalized bovine mammary epithelial cells express stem cell markers and differentiate in vitro. Cell Biology International. 2016 Aug;40(8):861-72. (IF5=3.8；JCR：2区) （共同作者，4/7）

2015

1. 代文婷, 郑楠, 李爱军, 王加启*. 亮氨酸水平对奶牛乳腺上皮细胞增殖及κ-酪蛋白合成相关基因表达的影响[J].动物营养学报. 2015,05:1559-1566.（中文核心期刊，独立第一）

2014

1. 代文婷, 郑楠, 赵圣国, 王加启*. 瘤胃壁黏附细菌的多样性及其影响因素. 动物营养学报. 2014,02:304- 310. （中文核心期刊，独立第一）

国际会议报告

1. Wenting Dai ; Mitochondrial metabolism as a target for cancer therapy, 2024年第一届生物医学智能计算国际会议（药物靶点发现分论坛）, 浙江杭州, 2024-11-28至2024-11-30 (口头报告).

2. Wenting Dai, Qiong A. Wang, Lei Jiang. FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress, The 6^th Mitochondria Syposium, UCLA, 美国洛杉矶, 2023-12-7至2023-12-9 (Oral Presentation).

3. Wenting Dai, Qiong A. Wang, and Lei Jiang. FASN deficiency induces a cytosol-to-mitochondria citrate flux to mitigate detachment-induced oxidative stress. 2023 Biology of Cancer: Microenvironment& Metastasis meeting, Cold Spring Harbor Laboratory Meetings , Cold Spring Harbor Laboratory, 美国纽约, 2023-9-19至2023-9-23 (Oral Presentation).

4. Wenting Dai and Lei Jiang. FASN-deficiency induces a cytosol-to-mitochondria citrate flux to mitigate oxidative stress during metastatic transition, 2022 Annual RSO Advance Conference, 美国洛杉矶, 2022-5-21至2022-5-22 (Poster)

5. Wenting Dai and Lei Jiang.OPA1-deficient cells rely on reductive carboxylation for proliferation, 2021 Annual RSO Advance Conference, 美国洛杉矶, 2021-4-26至2021-4-27 (Poster)

6. Wenting Dai and Hongyun Liu. ASCT2 and SARS are involved in Met-stimulated β-casein synthesis in bovine mammary epithelial cells, 2019 American Chemical Society National Annual Meeting, 美国圣地亚哥, 2019-8-25至2019-8-29 (Oral Presentation)

7. Wenting Dai and Hongyun Liu. Understanding the regulatory mechanisms of milk production using integrative transcriptomic and proteomic analyses: Reducing inefficient utilization of crop by-products as forage in dairy industry, 2017 ADSA(American Dairy Science Association)-ASAS(Society of Animal Science) Joint Annual Meeting, 美国匹兹堡, 2017-6-24至2017-6-28 (Oral Presentation)

7. Wenting Dai and Hongyun Liu. Comparative transcriptomic analysis of the lactating and nonlactating bovine mammary gland, 2017 ADSA(American Dairy Science Association)-ASAS (Society of Animal Science) Joint Annual Meeting, 美国匹兹堡, 2017-6-24至2017-6-28 (Oral Presentation).

8. Wenting Dai and Jiaqi Wang. A cow mammary epithelial cell-free system based on crude lysosomes and cytosol proteins: leucine activating mTOR at Ser2448, 2015 ADSA(American Dairy Science Association)-ASAS (Society of Animal Science) Joint Annual Meeting, 美国奥兰多, 2015-7-12至2015-7-16 (Oral Presentation).

专利

1 郑楠, 胡菡, 王加启, 高海娜, 代文婷. 永生化奶牛乳腺上皮细胞系及其构建方法和应用。发明专利号（ZL 201410104004.4）

奖励

1 王涛、刘红云、赵元、代文婷. 牛奶功能性脂肪酸和蛋白质合成与调控机理研究（2020.11.4），吉林省教育委员会，吉林省科学技术进步奖二等奖。

受邀担任Journal of Biomedical Science、Journal of Nutrition、Journal of Agricultural and Food Chemistry、BMC Genomics等期刊的审稿专家。

受邀担任美国化学学会和美国奶业协会会员。