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更新时间：2026.11.07
总访问量：10

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| 博士 助理研究员 请选择

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电子邮箱： douzhe@zjut.edu.cn
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  • 个人简介

    江南大学发酵工程博士，本科毕业于西北农林科技大学。

    2023-2025年在浙江工业大学从事博士后研究。

    2025年受聘于浙江工业大学药学院、朝晖特聘副研究员。

    研究主要聚焦于生物催化与酶工程，在Nat. Commun., ACS Catal., Small, Bioresource Technol., Org. Lett.等期刊发表SCI论文10余篇，授权发明专利10余项。

    先后获得中国博士后科学基金项目、浙江省自然科学基金青年基金项目及国家自然科学基金青年基金项目的资助，参与横向及省级重点等课题3项。


    「研究方向：从基础到应用主要包括（1）新型酶资源的挖掘与表征；（2）酶分子改造与催化体系的构建；（3）酶分子机制与催化动力学解析；（4）工业生物催化与绿色工艺开发。」


  • 科研成果

    1. Xu JN, Zhao MM, Xu CL, Wang X, Dou Z*, Wang YJ. Deep learning-driven discovery and engineering of imine reductase for the efficient synthesis of chiral opine derivatives. ACS Catal., 2026, DOI: 10.1021/acscatal.6c06352

    2. Zhao MM, Dou Z*, Xu JN, Yan HX, Cheng YQ, Wang YJ*. An engineered imine reductase with enhanced activity and thermostability for the asymmetric synthesis of chiral naphthylalkylamines. ACS Catal., 2026, 16, 9569–9581.

    3. Zhu JQ, Dou Z*, Tang HN, Yan HX, Wang YJ*. Rigid-flexible layered immobilization enables precise confinement and dynamic activation of small enzymes. Small, 2026, 22, e12609.

    4. Dou Z, Chen XZ, Zhu LD, Zheng XY, Chen XY, Xue JY, Niwayama S, Ni Y, Xu GC. Enhanced stereodivergent evolution of carboxylesterase for efficient kinetic resolution of near-symmetric esters through machine learning. Nat. Commun., 2024, 15, 9057.

    5. Xu CL, Song LL, Li MJ, Ju SY, Dou Z*, Wang YJ. Engineering size-complementary alcohol dehydrogenase mutants for highly stereoselective synthesis of bulky diaryl and aliphatic diols. Org. Lett., 2026, DOI: 10.1021/acs.orglett.6c03975

    6. Dou Z, Yan HX, Xu CL, Xu JN, Zhao MM, Wang YJ*. Engineering an (R)-selective transaminase for high-substrate-loading asymmetric amination of a sterically demanding N-heterocyclic ketone. Biotechnol. Bioeng., 2026, DOI: 10.1002/bit.70376.

    7. Zhao MM, Xu JN, Chen JH, Dou Z*, Wang YJ. Highly diastereo- and enantioselective imine reductases engineered for γ-piperidinamines bearing contiguous stereocenters. Biotechnol. Bioeng., 2026, DOI: 10.1002/bit.70416

    8. Xu CL, Zhao LH, Tang J, Song XH, Dou Z*, Wang YJ. Structure-Guided Engineering of Alcohol Dehydrogenase for the Stereodivergent Synthesis of Amino Alcohols via Desymmetrization of Cyclic Diketones. Biotechnol. Bioeng‌., 2026, 123, 1380–1392.

    9. Dou Z, Hu PR, Song LL, Wang YC, Tang HN, Weng ZQ, Wang YJ, Cai YQ. Extensive gene mining and facile engineering of a novel carbonyl reductase for asymmetric synthesis of anti-aging (S)-Pro-Xylane from d-xylose. Int. J. Biol. Macromol., 2025, 305, 140976.

    10. Dou Z, Chen XZ, Niwayama S, Xu GC, Ni Y. Kinetic resolution of nearly symmetric 3-cyclohexene-1-carboxylate esters using a bacterial carboxylesterase identified by genome mining. Org. Lett., 2021, 23, 3043–3047.

    11. Dou Z, Xu GC, Ni Y. A novel carboxylesterase from Acinetobacter sp. JNU9335 for efficient biosynthesis of Edoxaban precursor with high substrate to catalyst ratio. Bioresource Technol., 2020, 317, 123984.

    12. Dou Z, Jia P, Chen XY, Wu Z, Xu GC, Ni Y. Structural and mechanistic insights into enantioselectivity toward near-symmetric esters of a novel carboxylesterase RoCE. Catal. Sci. Technol., 2022, 12,7448–7456.

    13. Dou Z, Xu GC, Ni Y. Efficient microbial resolution of racemic methyl 3-cyclohexene-carboxylate as chiral precursor of Edoxaban by newly identified Acinetobacter sp. JNU9335. Enzyme. Microb. Technol., 2020, 139, 109580.

     


  • 教学与课程

    本科生：《酶工程》；《分子生物学与基因工程》

  • 科研项目

    1. 国家自然科学基金青年基金（C类），2026.01-2028.12，主持

    2. 浙江省自然科学基金青年基金，2025.12-2027.12，主持

    3. 中国博士后科学基金第75批面上资助，2024.07-2025.10，主持



  • 个人简介

    江南大学发酵工程博士，本科毕业于西北农林科技大学。

    2023-2025年在浙江工业大学从事博士后研究。

    2025年受聘于浙江工业大学药学院、朝晖特聘副研究员。

    研究主要聚焦于生物催化与酶工程，在Nat. Commun., ACS Catal., Small, Bioresource Technol., Org. Lett.等期刊发表SCI论文10余篇，授权发明专利10余项。

    先后获得中国博士后科学基金项目、浙江省自然科学基金青年基金项目及国家自然科学基金青年基金项目的资助，参与横向及省级重点等课题3项。


    「研究方向：从基础到应用主要包括（1）新型酶资源的挖掘与表征；（2）酶分子改造与催化体系的构建；（3）酶分子机制与催化动力学解析；（4）工业生物催化与绿色工艺开发。」


  • 科研成果

    1. Xu JN, Zhao MM, Xu CL, Wang X, Dou Z*, Wang YJ. Deep learning-driven discovery and engineering of imine reductase for the efficient synthesis of chiral opine derivatives. ACS Catal., 2026, DOI: 10.1021/acscatal.6c06352

    2. Zhao MM, Dou Z*, Xu JN, Yan HX, Cheng YQ, Wang YJ*. An engineered imine reductase with enhanced activity and thermostability for the asymmetric synthesis of chiral naphthylalkylamines. ACS Catal., 2026, 16, 9569–9581.

    3. Zhu JQ, Dou Z*, Tang HN, Yan HX, Wang YJ*. Rigid-flexible layered immobilization enables precise confinement and dynamic activation of small enzymes. Small, 2026, 22, e12609.

    4. Dou Z, Chen XZ, Zhu LD, Zheng XY, Chen XY, Xue JY, Niwayama S, Ni Y, Xu GC. Enhanced stereodivergent evolution of carboxylesterase for efficient kinetic resolution of near-symmetric esters through machine learning. Nat. Commun., 2024, 15, 9057.

    5. Xu CL, Song LL, Li MJ, Ju SY, Dou Z*, Wang YJ. Engineering size-complementary alcohol dehydrogenase mutants for highly stereoselective synthesis of bulky diaryl and aliphatic diols. Org. Lett., 2026, DOI: 10.1021/acs.orglett.6c03975

    6. Dou Z, Yan HX, Xu CL, Xu JN, Zhao MM, Wang YJ*. Engineering an (R)-selective transaminase for high-substrate-loading asymmetric amination of a sterically demanding N-heterocyclic ketone. Biotechnol. Bioeng., 2026, DOI: 10.1002/bit.70376.

    7. Zhao MM, Xu JN, Chen JH, Dou Z*, Wang YJ. Highly diastereo- and enantioselective imine reductases engineered for γ-piperidinamines bearing contiguous stereocenters. Biotechnol. Bioeng., 2026, DOI: 10.1002/bit.70416

    8. Xu CL, Zhao LH, Tang J, Song XH, Dou Z*, Wang YJ. Structure-Guided Engineering of Alcohol Dehydrogenase for the Stereodivergent Synthesis of Amino Alcohols via Desymmetrization of Cyclic Diketones. Biotechnol. Bioeng‌., 2026, 123, 1380–1392.

    9. Dou Z, Hu PR, Song LL, Wang YC, Tang HN, Weng ZQ, Wang YJ, Cai YQ. Extensive gene mining and facile engineering of a novel carbonyl reductase for asymmetric synthesis of anti-aging (S)-Pro-Xylane from d-xylose. Int. J. Biol. Macromol., 2025, 305, 140976.

    10. Dou Z, Chen XZ, Niwayama S, Xu GC, Ni Y. Kinetic resolution of nearly symmetric 3-cyclohexene-1-carboxylate esters using a bacterial carboxylesterase identified by genome mining. Org. Lett., 2021, 23, 3043–3047.

    11. Dou Z, Xu GC, Ni Y. A novel carboxylesterase from Acinetobacter sp. JNU9335 for efficient biosynthesis of Edoxaban precursor with high substrate to catalyst ratio. Bioresource Technol., 2020, 317, 123984.

    12. Dou Z, Jia P, Chen XY, Wu Z, Xu GC, Ni Y. Structural and mechanistic insights into enantioselectivity toward near-symmetric esters of a novel carboxylesterase RoCE. Catal. Sci. Technol., 2022, 12,7448–7456.

    13. Dou Z, Xu GC, Ni Y. Efficient microbial resolution of racemic methyl 3-cyclohexene-carboxylate as chiral precursor of Edoxaban by newly identified Acinetobacter sp. JNU9335. Enzyme. Microb. Technol., 2020, 139, 109580.

     


  • 教学与课程

    本科生：《酶工程》；《分子生物学与基因工程》

  • 科研项目

    1. 国家自然科学基金青年基金（C类），2026.01-2028.12，主持

    2. 浙江省自然科学基金青年基金，2025.12-2027.12，主持

    3. 中国博士后科学基金第75批面上资助，2024.07-2025.10，主持



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更新时间：2026.11.07
总访问量：10