程峰

 教授、博导、副院长。从事工业酶创制及手性化学品合成的应用基础研究，2015年博士毕业于德国亚琛工业大学（师从于国际知名酶定向进化专家Ulrich Schwaneberg教授），先后主持了国家自然科学基金优青项目、面上项目、重点研发计划青年科学家项目等国家级项目10余项。以第一作者/通讯作者在Nature Comm, Angew Chem, ACS Catal，AIChE J, Biotechnol Bioeng等知名期刊发表SCI收录论文50余篇，授权中国、美国发明专利40余项。获浙江省技术发明一等奖（2024）和中国石油和化学工业联合会科技进步一等奖（2021）。

热忱欢迎对本课题组研究感兴趣的博士后、研究生、本科生和研究人员的加盟和交流合作！

教授课程

本科生：酶工程（浙江省一流课程）；生物工程设备（国家一流课程）

研究生：生物催化工程（校重点课程）

主要研究项目

1. 国家优秀青年科学基金项目(2023-2025, 200 万元，在研)

2. 国家自然科学基金委面上项目(2019-2022, 56 万元，结题)

3. 国家自然科学基金委青年基金(2017-2019, 23 万元，结题）

4. 国家重点研发计划 子课题 (2021-2024, 101万元，在研）

5. 浙江省重点研发计划 课题 (2021-2023, 92万元，结题）

6. 省属高校基本业务经费项目 (2019-2021, 10万元，在研）

7. 国家重点研发计划项目-青年项目 (2024-2027, 400万元，在研）

带领本科生获国家基因工程大赛金奖（2018、2019、2020）和浙江省“互联网+”大学生创新创业大赛金奖（2019）

代表性论文论著

发表SCI论文80余篇，代表作如下

2026年

(1) Chen, H., Gao, Y. T., Ge, X. Z., Wang, X., Cheng, F., Xue, Y. P., & Zheng, Y. G. (2025). Material-binding peptides: sources, mechanisms, directed evolution and applications. Biotechnology Advances, 108742.

2025年

(1) Xu S, Wang SH, Lou LW, Ji Y, Schwaneberg U, Li ZM, Cheng F, Li ZL. Modular multi-enzyme cascades enable green and sustainable synthesis of non-canonical amino acids from glycerol. Nat Commun. 2025 Aug 29;16(1):8079. doi: 10.1038/s41467-025-63341-1.

(2) Cheng, F., Li, J. M., Sun, F. Q., Gao, Y. T., Zou, S. P., Xu, J. M., ... & Zheng, Y. G. (2025). Construction of dual cofactor‐driven biocatalytic system for effective production of chiral amino acids. AIChE Journal, 71(8), e18894.

(3)  Cheng, F., Wu, S. S., Liu, H. Y., Li, H., Gao, Y. T., Xue, Y. P., & Zheng, Y. G. (2025). Restore the Activity and Stability of Nicotinamide Riboside Kinase by α‐Helix Reconstruction and Semi‐Rational Design. Biotechnology and Bioengineering, 122(12), 3319-3331

(4) Li, H., Ma, C. J., Gao, Y. T., Zhou, Q. Q., Chen, H., Cheng, F., ... & Zheng, Y. G. (2025). Protein engineering and flow reactor design for anchored peptide-mediated continuous biocatalysis. Chemical Engineering Journal, 167993.

(5) Zhou, Y. C., Ma, C. J., Chen, H., Fu, C. C., Cheng, F., Liu, Z. Q., & Zheng, Y. G. (2025). Mechanistic Insights into Enzyme Gate Engineering of ω-Transaminase for Regulating Organic Solvent Resistance. Journal of Agricultural and Food Chemistry, 73(31), 19607-19617

(6) Cheng, F., Zhou, Y. L., Yang, D. C., Zhao, D. Y., Xue, Y. P., & Zheng, Y. G. (2025). Advances in biosynthesis of chiral amide herbicides and the key enzymes: dimethenamid-P and S-metolachlor as case studies. Bioresources and Bioprocessing, 12(1), 17

(7) Cui, D., Cai, X., Duan, X., Chu, Y., Li, B., Wang, Z., ...Cheng, F & Xu, J. (2025). Metalloenzyme‐Catalyzed Asymmetric Transfer Hydrogenation for the Synthesis of Chiral Amines. Angewandte Chemie International Edition, 64(36), e202511298

2024年

(1) Cheng F, Sun KX, Gong XX, Peng W, Zhang HY, Liang XH, Xue YP, Zheng YG. Development of growth selection system and pocket engineering of d-amino acid oxidase to enhance selective deamination activity toward d-phosphinothricin. Biotechnol Bioeng. 2024; 121(9):2893-2906. doi: 10.1002/bit.28763. 

(2) Cheng F, Li KX, Wu SS, Liu HY, Li H, Shen Q, Xue YP, Zheng YG. Biosynthesis of Nicotinamide Mononucleotide: Synthesis Method, Enzyme, and Biocatalytic System. J Agric Food Chem. 2024; 72(7):3302-3313. doi: 10.1021/acs.jafc.3c09217.

(3) Cheng F, Wang C-J, Gong X-X, Sun K-X, Liang X-H, Xue Y-P, Zheng Y-G. Assembly and engineering of BioBricks to develop an efficient NADH regeneration system. Appl Environ Microbiol. 2025; 91(1):e0104124.

2023年

(1) Feng Cheng, Sheng-Yi Zhou, Lu-Xin Chen, Wei Zhang, Shu-Fang Li, Chun-Yue Weng, Ya-Jun Wang, Yu-Guo Zheng, Reaction-kinetic model-guided biocatalyst engineering for dual-enzyme catalyzed bioreaction system, Chemical Engineering Journal 452 (2023) 138997

(2) Cheng F, Wei L, Wang CJ, Liang XH, Xu YQ, Xue YP, Zheng YG. Switching the Cofactor Preference of Formate Dehydrogenase to Develop an NADPH-Dependent Biocatalytic System for Synthesizing Chiral Amino Acids. J Agric Food Chem. 2023;71(23):9009-9019.

(3) Feng Cheng, Xiao-Hu Wu, Huan Li, Ke-Xin Li, Qian Guo, Qi Shen, Ya-Ping Xue*, and Yu-Guo Zheng, Streamlining Design, Engineering, and Applications of Nicotinamide Riboside Kinase for Sustainable Biosynthesis of Nicotinamide Mononucleotide in Flow, ACS Sustainable Chemistry & Engineering; 2023, 11, 42, 15218–15227

2022年

(1) Cheng F, Li MY, Wei DJ, Zhang XJ, Jia DX, Liu ZQ, Zheng YG. Enabling biocatalysis in high-concentration organic cosolvent by enzyme gate engineering. Biotechnol Bioeng. 2022, 119(3):845-856. 

(2) Feng Cheng, Jia-Min Zhang, Zhen-Tao Jiang, Xiao-Hu Wu, Ya-Ping Xue, Yu-Guo Zheng, Development of an NAD(H)-Driven Biocatalytic System for Asymmetric Synthesis of Chiral Amino Acids, Adv Synth Catal 2022, 364, 1450–1459 (VIP paper).

(3) Feng Cheng, Dong-Yang Wu, Xi-Hang Liang, Cheng-Jiao Wang, Jia-Qi Weng, Shu-Ping Zou,  Jian-Miao Xu, Ya-Ping Xue and Yu-Guo Zheng. A Light-controlled Biocatalytic System for Precise Regulation of Enzymatic Decarboxylation, Catalysis Science & Technology,2022 12, 3421 - 3425.

(4) Cheng F, Xie WB, Gao XF, Chu RL, Xu SY, Wang YJ, Zheng YG. Development of a new chemo-enzymatic catalytic route for synthesis of (S)-2-chlorophenylglycine. J Biotechnol. 2022 358:17-24.

2021年

(1) Cheng F, Chen Y, Qiu S, Zhai QY, Liu HT, Li SF, Weng CY, Wang YJ*, Zheng YG. Controlling stereopreferences of carbonyl reductases for enantioselective synthesis of atorvastatin precursor. ACS Catal., 2021, 11: 2572–2582

(2) Cheng F, Li QH, Zhang HY, Wei L, Zhang JM, Li JM, Xue YP*, Zheng YG. Simultaneous directed evolution of coupled enzymes for efficient asymmetric synthesis of l-phosphinothricin. Appl. Environ. Microbiol., 2021, 87: e02563-20

(3) Cheng F, Zhai QY, Gao XF, Liu HT, Qiu S, Wang YJ, Zheng YG. Tuning enzymatic properties by protein engineering toward catalytic tetrad of carbonyl reductase.Biotechnol Bioeng., 2021,118(12):4643–4654

2020年

(1) Cheng F, Li H, Wu DY, Li JM, Fan Y, Xue YP*, Zheng YG. Light-driven deracemization of phosphinothricin by engineered fatty acid photodecarboxylase on a gram scale. Green Chem., 2020, 22, 6815–6818

(2) Cheng F, Li H, Zhang K, Li QH, Xie D, Xue YP*, Zheng YG. Tuning amino acid dehydrogenases with featured sequences for L-phosphinothricin synthesis by reductive amination. J Biotechnol., 2020, 312:35–43

(3) Cheng F, Chen XL, Xiang C, Liu ZQ, Wang YJ, Zheng YG.Fluorescence-based high-throughput screening system for R-ω-transaminase engineering and its substrate scope extension Appl Microbiol Biotechnol . 2020;104(7):2999-3009

2019年以前

(1) Cheng F, Yang J, Schwaneberg U, Zhu L*. Rational surface engineering of an arginine deiminase (an antitumor enzyme) for increased PEGylation efficiency. Biotechnol. Bioeng., 2019, 116: 2156–2166

(2) Wang G, Lu X, Zhu Y, Zhang W, Liu J, Wu Y, Yu L, Sun D*, Cheng F*. A light-controlled cell lysis system in bacteria. J Ind Microbiol Biotechnol. 2018, 45: 429-432

(3) Cheng F, Tang XL, Kardashliev T. Transcription Factor-Based Biosensors in High-Throughput Screening: Advances and Applications. Biotechnol J. 2018;13(7):e1700648.

(4) Cheng F, Yang J, Schwaneberg U, Zhu L*. Rational surface engineering of an arginine deiminase (an antitumor enzyme) for increased PEGylation efficiency. Biotechnol. Bioeng., 2019, 116: 2156–2166

(5) Cheng F, Kardashliev T, Pitzler C, Shehzad A, Lue H, Bernhagen J, Zhu L* Schwaneberg U*, 2015, A competitive flow cytometry screening system for directed evolution of therapeutic enzyme. ACS Syn. Biol., 2015, 4: 768-775.

(6) Cheng F, Zhu L, Schwaneberg U*, Directed evolution 2.0: improving and deciphering enzyme properties. Chem. Comm. 2015, 51: 9760-9772.

发明专利

获授权专利16项，代表性专利如下

1.一种草铵膦脱氢酶突变体及其应用ZL201811585674.7 (授权)

2.一种氨基转移酶、突变体及其制备西他列汀的应用ZL201710543569.6 (授权)

3.一种D-氨基酸氧化酶突变体及其应用ZL201811618942.0 (授权)

浙江省药学会、微生物学会、生物信息学会青年委员。