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更新时间:2024.08.20
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黄亮

| 博士 副研究员 博士生导师

单位:

职务:

研究方向:

办公地址: 化工学院5号楼A316

办公电话:

电子邮箱: lhuang@zjut.edu.cn

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  • 个人简介

    黄亮,博士,副研究员,博士生导师。2013年毕业于华中农业大学获博士学位。2013年至2015年于中国科学院深圳先进技术研究院从事博士后研究。2015年至2017年加入中国科学院深圳先进技术研究院担任副研究员。20175月加入浙江工业大学-化学工程学院担任副研究员。长期从事功能纳米基元的控制合成及可控组装研究,从金属/半导体/氧化物纳米基元功能设计到组装优化层面,实现对磁性及光学等性能的集成与协同,并开展了相关生物医学及体外诊断应用研究。作为项目负责人承担国家自然科学基金面上项目、青年科学基金项目、中国博士后科学基金、浙江省自然科学基金、浙江省公益技术研究计划、深圳市科技计划等科研项目。发表SCI论文40余篇,以第一作者或通讯作者在Adv. Mater., Angew. Chem. Int. Ed., Adv. Funct. Mater., Small, Chem. Mater., ACS Appl. Mater. Interfaces等国际期刊发表论文20余篇。授权发明专利10余项。2016年入选深圳市高层次专业人才、深圳市南山区领航人才,2017年入选绍兴市娥江英才创业人才项目。担任Advanced Functional Materials、《ACS Applied Materials & Interfaces》、Analytical Chemistry》、Biomaterials等国际期刊审稿人。

      研究方向:

    (1)量子点超敏荧光免疫传感 (病原体抗原/抗体检测、心梗即时诊断、肿瘤早筛快检)

    (2)纳米磁珠生物纯化技术与产业化应用(磁微粒化学发光免疫诊断)

    (3)荧光编码即时诊断分析(蛋白标志物多靶标联检)


  • 科研项目

    1. 国家自然科学基金面上项目(21875218),基于新一代量子点探针的心肌多标志物POCT联合诊断研究,2019-2022项目负责人

    2.国家自然科学基金青年基金项目(21501191),基于贵金属@二氧化钛异质纳米棒阵列的SERS传感-光催化双功能界面构筑及性能研究,2016-2018项目负责人

    3.中国博士后科学基金项目2014M560683),非均质纳米棒可控自组装用于新型三维SERS基底的构建,2014-2015项目负责人

    4. 浙江省自然科学基金项目(LY24B010004),颜色识别免疫层析用于呼吸道病毒抗原的居家可视化诊断2024-2026项目负责人

    5. 浙江省基础公益研究计划项目(LGF20B010001),基于可控组装探针的血液降钙素原高灵敏快速诊断研究,2020-2022项目负责人

    6. 深圳市科技计划基础研究项目(JCYJ20150630114942307),贵金属@二氧化钛精细纳米结构阵列用于环境污染物的高灵敏检测及光催化降解研究,2015-2017项目负责人

    7. 国家自然科学基金面上项目(31571013),环境共响应近红外纳米分子探针及肿瘤诊疗一体化研究,2016-2019,项目组成员。

    8.国家自然科学基金面上项目(21375043),量子点近红外电致化学发光及其成像研究,2014-2017,项目组成员。

    9. 国家自然科学基金面上项目(21175051),量子点双光子荧光成像技术用于猪圆环病毒2型致病机理研究,2012-2015,项目组成员。


  • 科研成果

    发表论文:ORCID个人主页  https://orcid.org/0000-0002-4789-7068

    (30) Yefeng Zhu, Lijiao Ao, Sai Chu, Yuting Liao, Jing Wang*, Jun Hu*, and Liang Huang*, Semiconductor Nanoplatelets Based Host-Guest Assembly Structure with High Color Purity for Hue-Recognizable Lateral Flow Immunoassay. Adv. Funct. Mater. 2024, 2316147.

    (29) Jing Wang, Daquan Li, Yingxiang Ye, Yu Qiu, Jiawei Liu, Liang Huang*, Bin Liang*, Banglin Chen*. A Fluorescent Metal-Organic Framework for Food Real-Time Visual Monitoring. Adv. Mater. 2021, 33, 15, 02008020.

    (28) Jing Wang, Chenxing Jiang, Jiening Jin, Liang Huang*, Wenbo Yu, Bin Su*, Jun Hu*. Ratiometric Fluorescent Lateral Flow Immunoassay for Point-of-Care Testing of Acute Myocardial Infarction. Angew. Chem. Int. Ed. 2021, 60, 23, 13042-13049.

    (27) Chi Chen, Lijiao Ao, Yu-Tang Wu, Vjona Cifliku, Marcelina Cardoso Dos Santos, Emmanuel Bourrier, Martina Delbianco, David Parker, Jurriaan M. Zwier, Liang Huang*, Niko Hildebrandt*. Single-Nanoparticle Cell Barcoding by Tunable FRET from Lanthanides to Quantum Dots. Angew. Chem. Int. Ed. 2018, 57, 41, 13686-13690.

    (26) Liang Huang, Tao Liao, Jing Wang, Lijiao Ao, Wu Su*, Jun Hu*. Brilliant Pitaya-Type Silica Colloids with Central-Radial and High-Density Quantum Dots Incorporation for Ultrasensitive Fluorescence Immunoassays. Adv. Funct. Mater. 2018, 28, 4, 1705380.

    (25) Liang Huang, Yuxing Zhang, Tao Liao, Kui Xu, Chenxing Jiang, Dinglv Zhuo, Yang Wang, Hui-Min Wen, Jing Wang*, Lijiao Ao*, Jun Hu*. Compact Magneto-Fluorescent Colloids by Hierarchical Assembly of Dual-Components in Radial Channels for Sensitive Point-of-Care Immunoassay. Small  2021, 17, 2100862.

    (24) Lijiao Ao, Tao Liao, Liang Huang*, Shan Lin, Kui Xu, Jiangtao Ma, Shaorong Qiu, Xiangyu Wang*, Qiqing Zhang*. Sensitive and Simultaneous Detection of Multi-Index Lung Cancer Biomarkers by an NIR-II Fluorescence Lateral-Flow Immunoassay Platform. Chem. Eng. J. 2022, 436, 135204.

    (23) Lu Tong, Daquan Li, Mei Huang, Liang Huang*, and Jing Wang*. Gold-Silver Alloy Nanoparticle-Incorporated Pitaya-Type Silica Nanohybrids for Sensitive Competitive Lateral Flow Immunoassay. Anal. Chem. 2023, 95, 47, 17318-17327.

    (22) Jing Wang, Chenxing Jiang, Jingrui Yuan, Lu Tong, Yang Wang, Dinglv Zhuo, Liang Huang*, Weihong Ni, Jiafeng Zhang, Mei Huang, Daquan Li, Bin Su*, Jun Hu*. Hue Recognition Competitive Fluorescent Lateral Flow Immunoassay for Aflatoxin M1 Detection with Improved Visual and Quantitative Performance. Anal. Chem. 2022, 94, 30, 10865-10873.

    (21) Daquan Li, Mei Huang, Ziyu Shi, Liang Huang*, Jiening Jin, Chenxing Jiang, Wenbo Yu, Zhiyong Guo, Jing Wang*. Ultrasensitive Competitive Lateral Flow Immunoassay with Visual Semiquantitative Inspection and Flexible Quantification Capabilities. Anal. Chem. 2022, 94, 6, 2996-3004.

    (20) Jianghua Jia, Lijiao Ao, Yongxin Luo, Tao Liao, Liang Huang*, Dinglv Zhuo, Chenxing Jiang, Jing Wang*, Jun Hu*. Quantum dots assembly enhanced and dual-antigen sandwich structured lateral flow immunoassay of SARS-CoV-2 antibody with simultaneously high sensitivity and specificity. Biosens. Bioelectron. 2021, 113810.

    (19) Liang Huang, Jiening Jin, Lijiao Ao, Chenxing Jiang, Yuxing Zhang, Hui-Min Wen, Jing Wang*, Haiyan Wang*, Jun Hu*. Hierarchical plasmonic-fluorescent labels for highly sensitive lateral flow immunoassay with flexible dual-modal switching, ACS Appl. Mater. Interfaces 2020, 12, 52, 58149-58160.

    (18) Liang Huang, Ziyu Shi, Daquan Li, Chenxing Jiang, Xuexue Wang, Mei Huang, Jing Wang,* and Bin Su. Hue-Recognition Strategy-Based Immunoassay Using Functionalized Dendritic Silica Colloids and Gold Nanoclusters for Point-of-Care Testing of C‑Reactive Proteins. ACS Appl. Nano Mater. 2023, 6, 86-95.

    (17) Liang Huang, Tian Tian, Ying Zhang, Yuting Liao, Jing Wang*. Controllable synthesis of sandwich-type magnetic beads for procalcitonin detection on a magnetic enzyme-linked immunosorbent assay. Microchemical Journal 2024, 199, 110114.

    (16) Xiaofeng Hu, Liang Huang (co-first author), Shenling Wang, Rajib Ahmed, Peiwu Li, Utkan Demirci, Zhaowei Zhang*. Color-selective labyrinth-like quantum dot nanobeads enable point-of-care dual assay of of Mycotoxins. Sensor. Actuat. B-Chem. 2023, 376, 132956. 

    (15) Lijiao Ao, Xinjia Hu, Meng Xu, Qiqing Zhang*, Liang Huang*. Central-Radial Bi-Porous Nanocatalysts with Accessible High Unit Loading and Robust Magnetic Recyclability for 4-Nitrophenol Reduction. Dalton Trans. 2020, 49, 4669-4674.

    (14) Liang Huang, Jiening Jin, Jing Wang, Chenxing Jiang, Meng Xu, Huimin Wen, Tao Liao*, Jun Hu*. Homogeneous and high-density gold unit implanted optical labels for robust and sensitive point-of-care drug detection. Nanoscale 2019, 11(34), 16026-16035.

    (13) Lijiao Ao, Chunlei Wu, Ke Liu, Wei Wang, Lijing Fang, Liang Huang*,Wu Su*. Polydopamine Derivated Hierarchical Nanoplatform for Efficient Dual-Modal Imaging Guided Combination In Vivo Cancer Therapy. ACS Appl. Mater. Interfaces 2018, 10, 12544-12552.

    (12) Liang Huang, Lijiao Ao, Dehong Hu, Wei Wang, Zonghai Sheng, Wu Su*. Magneto-Plasmonic Nanocapsules for Multimodal-Imaging and Magnetically Guided Combination Cancer Therapy. Chem. Mater. 2016, 28(16), 5896-5904.

    (11) Liang Huang, Lijiao Ao, Xiaobin Xie, Guanhui Gao, Mohamed F. Foda, Wu Su*. Iron Oxide Nanoparticle Layer Templated by Polydopamine Spheres: a Novel Scaffold toward Hollow-Mesoporous Magnetic Nanoreactors. Nanoscale 2015, 7(2), 806-813.

    (10) Liang Huang, Lijiao Ao, Wei Wang, Dehong Hu, Zonghai Sheng, Wu Su*. Multifunctional Magnetic Silica Nanotubes for MR Imaging and Targeted Drug Delivery. Chem. Commun. 2015, 51(18), 3923-3926.

    (9) Liang Huang, Qiong Wu, Jing Wang, Mohamed Foda, Jiawei Liu, Kai Cai, Heyou Han*. A Brilliant Sandwich Type Fluorescent Nanostructure Incorporating a Compact Quantum Dot Layer and Versatile Silica Substrates. Chem. Commun. 2014, 50(22), 2896-2899.

    (8) Liang Huang, Zhihui Luo, Heyou Han*. Organosilane Micellization for Direct Encapsulation of Hydrophobic Quantum Dots into Silica Beads with Highly Preserved Fluorescence. Chem. Commun. 2012, 48(49), 6145-6147.

    (7) Liang Huang, Heyou Han*. One-Step Synthesis of Water-Soluble ZnSe Quantum Dots via Microwave Irradiation. Mater. Lett. 2010, 64(19), 1099-1101.

    (6) Mohamed F. Foda, Liang Huang, Feng Shao, Heyou Han*. Biocompatible and highly luminescent near-infrared CuInS2/ZnS quantum dots embedded silica beads for cancer cell Imaging. ACS Appl. Mater. Interfaces 2014, 6, 2011-2017.

    (5) Zeshan Leng, Liang Huang, Feng Shao, Zhicheng Lv, Tingting Li, Xiaoxu Gu, Heyou Han*. Facile synthesis of Cu-In-Zn-S alloyed nanocrystals with temperature-dependent photoluminescence spectra. Mater. Lett. 2014, 119, 100-103.

    (4) Chi Chen, Ben Corry*, Liang Huang, Niko Hildebrandt*. FRET-Modulated Multihybrid Nanoparticles for Brightness-Equalized Single-Wavelength Barcoding. J. Am. Chem. Soc. 2019, 141, 11123-11141.

    (3) Jing Wang, Xinyue Liu, Liang Huang, Jiening Jin, Chenxing Jiang, Daquan Li, Huimin Wen, Jun Hu*. Controllable and robust dual-emissive quantum dot nanohybrids as inner filter-based ratiometric probes for visualizable melamine detection. Nanoscale 2020, 12, 4562-4572.

    (2) Jing Wang, Zhili Zuo, Liang Huang, Muhammad Asif Warsi, John Q. Xiao*, Jun Hu*. Novel gradient-diameter magnetic nanowire arrays with unconventional magnetic anisotropy behaviors. Chem. Commun. 2018, 54, 7515-7518.

    (1) Qiong Wu, Lu Chen, Liang Huang, Jing Wang, Jiawei Liu, Chao Hu, Heyou Han*. Quantum dots decorated gold nanorod as fluorescent-plasmonic dual-modal contrasts agent for cancer imaging. Biosens. Bioelectron. 2015, 74, 16-23.

    授权发明专利:

    (15) 黄亮金洁宁胡军汪晶基于双亲性硅载体的量子点荧光纳米球及其制备方法. 中国发明专利:  ZL201910802130.X. 授权公告日,2022.07.26.

    (14) 黄亮金洁宁胡军汪晶一种基于多层级组装结构的荧光/比色双功能微球及其制备方法中国发明专利ZL201910820570.8. 授权公告日,2022.05.03.

    (13) 黄亮金洁宁胡军汪晶基于金纳米颗粒高效组装结构的光学探针及其制备与应用. 中国发明专利:  ZL201811472000.6. 授权公告日,2022.03.15

    (12) 黄亮蒲昊昊胡军一种多层级双孔结构复合光催化剂及其制备与应用. 中国发明专利: ZL201910858565.6. 授权公告日,2022.04.19. 

    (11) 黄亮,许萌,胡军,蒲昊昊.一种树状介孔模板负载二氧化钛光催化剂的制备方法.中国发明专利: ZL201910926684.0. 授权公告日,2022.03.25

    (10) 黄亮卓定吕汪晶敖丽娇一种基于量子点逐层亲和组装的高亮度荧光微球及其应用.中国发明专利:  ZL202111579570.7. 授权公告日,2023.09.12.

    (9) 黄亮张雨星汪晶一种多层级可控组装型荧光-磁性双功能微球及其制备方法、应用. 中国发明专利ZL202010560175.3. 授权公告日,2022.05.03.

    (8) 黄亮,吴枫,汪晶一种基于双色量子点比率荧光探针的C反应蛋白高灵敏免疫检测方法.  中国发明专利ZL202011308574.4. 授权公告日,2022.05.17.

    (7) 黄亮汪洋汪晶敖丽娇用于醇中痕量水快速检测的钙钛矿量子点/二氧化硅复合纳米探针及其应用方法. 中国发明专利: ZL202111534148.X. 授权公告日,2023.03.14.

    (6) 黄亮,汪晶,敖丽娇一种中心-径向填充型复合超顺磁微球及其制备方法与应用. 中国发明专利ZL202010511290.1. 权公告日,2022.04.05

    (5) 粟武黄亮敖丽娇超顺磁性纳米球及其制备方法. 中国发明专利ZL201310754576.2. 权公告日,2017.10.13.

    (4) 粟武黄亮敖丽娇一种超顺磁-等离子体复合微球及其制备方法. 中国发明专利 ZL201611202481.X. 权公告日,2020.11.20.

    (3) 粟武敖丽娇黄亮. Fe3O4-Au磁性纳米复合材料及其制备方法与应用. 中国发明专利ZL201310574805.2. 权公告日,2016.02.24. 

    (2) 韩鹤友谷小许黄亮. CuInS2纳米晶及CuInS2/ZnS核壳结构纳米晶的制备方法. 中国发明专利ZL201210138338.4. 权公告日,2014.03.12.

    (1) 粟武敖丽娇武春雷黄亮一种吡咯咪唑聚酰胺脂质体及其制备方法及其用途中国发明专

    ZL201611204774.1. 权公告日,2020-05-06.



  • 育人成果

    已培养硕士研究生11人,博士研究生1人作为指导教师指导研究生参加第五届互联网+”大学生创新创业大赛获得省赛金奖(项目名称:易赛科技-中国磁珠生物纯化新材料领跑者;项目组成员:蒋晨星、贾江花、李大权、金洁宁)。

  • 教学与课程

    • 《Analytical Chemistry》(留学生分析化学, 英文)

    • 《无机/分析化学实验I》

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更新时间:2024.08.20
总访问量:10