顾金苹

研究方向：

1. 国家自然科学基金青年科学基金项目，21906147，低剂量百菌清暴露幼鼠影响肠道菌群与胆汁酸共代谢研究，2020/01-2022/12，26.0万，在研；

2. 浙江省自然科学基金青年科学基金项目，LQ18B050003，利用代谢组学技术研究肠道细胞受不同肠道菌群代谢产物的代谢变化，2018/01-2020/12，8.0万，结题；

3. 中国博士后科学基金面上项目（二等），2017M612023，肠道菌群的代谢产物影响大肠癌细胞的代谢变化，2016/10-2018/10，5.0万，结题。

1. Jinping Gu, Yafei Cheng, Chenyang Ji, Ying Tao, and Meirong Zhao*, Analysis of the Different Metabolic Phenotypes of Metalaxyl Enantiomers in Adolescent Rat by Using ¹H NMR Based Urinary Metabolomics,Chem. Res. Toxicol.2020, 33, 6, 1449–1457; (SCI impact factor 2019: 3.731, Q2).

2. Gu Jinping, Huang Caihua, Hu Xiaomin, Xia Jinmei, Shao Wei, Lin Donghai*, NMR-based Tissue Metabolomic Analysis Clarifies Molecular Mechanisms of Gastric Carcinogenesis, Cancer Science, 2020, 111, 9: 3195-3209; (SCI impact factor 2019: 6.710, Q1)

3.Siqing Yue, Jie Yu, Yuan Kong, HaofengChen, ManfeiMao, ChenyangJi, Shuai Shao, Jianqiang Zhu, Jinping Gu*,Meirong Zhao*, Metabolomic modulations of HepG2 cells exposed to bisphenol analogues, Environment International, 2019, 129: 59-67; (SCI impact factor 2019: 9.621, Q1) .

4. Jinping Gu, Dan Shu, Feng Su, Yuanyuan Xie*, Xianrui Liang*, Analysis of metabolome changes in the HepG2 cells of apatinib treatment by using the NMR-based metabolomics,JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120 (11): 19137-19146; (SCI impact factor 2019:4.424, Q2).

5. Jinping Gu, Feng Su, PanPan Hong, Quan Zhang*, Meirong Zhao*, ¹H NMR-based metabolomic analysis of nine Organophosphate flame retardants metabolic disturbance in HepG2 cell line, Science of the Total Environment, 2019,665, 162-170; (SCI impact factor 2018: 7.962, Q1).

6. Jinping Gu,Yaqing Xiao, Dan Shu, Xianrui Liang, Xiaomin Hu, Yuanyuan Xie, Donghai Lin*, Hua Li*, Metabolomics analysis in serum from patients with colorectal polyp and colorectal cancer by ¹H-NMR spectrometry, Disease Markers, 3491852; (SCI impact factor 2019: 3.430, Q2).

7. Jinping Gu, Chenyang Ji, Siqing Yue, Dan Shu, Feng Su, Yinjun Zhang, Yuanyuan Xie*, Yi Zhang, Weiping Liu, and Meirong Zhao*, Enantioselective Effects of Metalaxyl Enantiomers in Adolescent Rat Metabolic Profiles Using NMR-Based Metabolomics, Environ. Sci. Technol., 2018, 52 (9): 5438–5447; (SCI impact factor 2019: 9.024, Q1).

8. Jinping Gu, Xiaomin Hu, Wei Shao, Tianhai Ji, Wensheng Yang, Huiqin Zhuo, Zeyu Jin, Huiying Huang, Jiacheng Chen, Caihua Huang*, Donghai Lin*, Metabolomic analysis reveals altered metabolic pathways in a rat model of gastric carcinogenesis. Oncotarget 2016, 11049. (SCI impact factor 2016: 5.168, Q1).

9. Wei Shao#, Jinping Gu#, Caihua Huang, Dan Liu, Huiying Huang, Zicheng Huang, Zhen Lin, Wensheng Yang, Kun Liu, Donghai Lin* and Tianhai Ji*. Malignancy-associated metabolic profiling of human glioma cell lines using 1H NMR spectroscopy. Molecular Cancer2014, 13:197; (SCI impact factor 2019: 15.302, Q1).

10. Taijie Lin#, Jinping Gu#, Caihua Huang, Suli Zheng, Xu Lin, Liangdi Xie*, and Donghai Lin*, ¹H NMR-Based Analysis of Serum Metabolites in Monocrotaline-Induced Pulmonary Arterial Hypertensive Rats. Disease Markers 2016 (2016) 1:11; (SCI impact factor 2019: 2.738, Q2).

11. Changjun Zhang, Ke Yang, Sihang Yu, Jing Su, Shengli Yuan, Jiaxin Han, Yan Chen , Jinping Gu, Tao Zhou, Renren Bai, Yuanyuan Xie*, Design, synthesis and biological evaluation of hydroxypyridinone-coumarin hybrids as multimodal monoamine oxidase B inhibitors and iron chelates against Alzheimer‘s disease, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019 180: 367-382; (SCI impact factor 2019: 5.572, Q1).

12. Chenyang Ji, Siqing Yue, Jinping Gu, Yuan Kong, Haofeng Chen, Chang Yu, Zhe Sun, Meirong Zhao, 7-Dibromocarbazole interferes with tube formation in HUVECs by altering Ang2 promoter DNA methylation status, Science of the Total Environment, 2019, 697, 134156 (SCI impact factor 2019: 6.551, Q1).

13. Zili Guo, Bo Li, Jinping Gu, Peixi Zhu, Feng Su, Renren Bai, Xianrui Liang, Yuanyuan Xie*, Simultaneous Quantification and Pharmacokinetic Study of Nine Bioactive Components of Orthosiphon stamineus Benth. Extract in Rat Plasma by UHPLC-MS/MS, Molecules, 2019, 24 (17),3057-69 (SCI impact factor 2019: 3.267, Q2).

14. Zili Guo, Xiaokang Jie, Peixi Zhu, Jian Sun, Jinping Gu, Feng Su, Renren Bai, Yuanyuan Xie*, Fragmentation pathways of deprotonated amide-sulfonamide CXCR4 inhibitors investigated by ESI-IT-MS ⁿ , ESI-Q-TOF-MS/MS and DFT calculations, J. Mass Spectrom. 2019, 54 (11), 869-877. (SCI impact factor 2019: 1.671, Q3)

15. Chenyang Ji, Chang Yu, Jianqiang Zhu, Yafei Cheng, Tian Tian, Bingqi Zhou, Jinping Gu, Jun Fan, Meirong Zhao*, Chirality, 2020, 32(8):1107-1118, (SCI impact factor 2019: 2.171, Q3)

16. Zhong-Rui Li#, Jie Li#, Jin-Ping Gu, Jennifer Lai, Brendan Duggan, Wei-Peng Zhang, Zhi-Long Li, Yong-Xin Li, Rong-Biao Tong, Ying Xu, Dong-Hai Lin, Pei-Yuan Qian*, Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin.Nat Chem Biol. 2016, 12(10):773-5. (SCI impact factor 2018: 12.154, Q1).

17. Zicheng Huang#, Wei Shao#, Jinping Gu, Xiaomin Hu, Yuanzhi Shi, Wenqi Xu, Caihua Huang* and Donghai Lin*. Effects of culture media on metabolic profiling of the human gastric cancer cell line SGC7901.Molecular BioSystems 2015, 1832-1840. (SCI impact factor 2018: 2.855, Q3).

18. Hang Yuan, Liu Liu, Jinping Gu, Yan Liu, Meijuan Fang, Yufen Zhao*, Distinguishing of Isomeric Aldohexose-Ketohexose Disaccharides by Electrospray Mass Spcectrometry in Positive Mode, Rapid communication in Mass Spectrometry 2015, 29(22):2167-74; (SCI impact factor 2018: 2.045, Q3).

19. Yingjian Yu, Chuang Yue,  Xionggui Lin, Shibo Sun, Jinping Gu, Xu He, Chuanhui Zhang, Wei Lin, Donghai Lin,  Xinli Liao, Binbin Xu, Suntao Wu,  Mingsen Zheng, Jing Li*, Junyong Kang*, and Liwei Lin*, ZIF‑8 Cooperating in TiN/Ti/Si Nanorods as Efficient Anodes in MicroLithium-Ion-Batteries. ACS APPLIED MATERIALS & INTERFACES 2016, 8, 3992-3999; (SCI impact factor 2018:8.456, Q1).