靳远祥

靳远祥，教授，博士生导师，生物资源与生物环保研究所所长，浙江省杰出青年基金获得者，教育部“生物净化与转化”创新团队骨干成员，SCI杂志Toxics编辑，连续入选爱思唯尔2021-2023年中国高被引学者。浙江省毒理学会生态毒理专业委员会委员、中国环境诱变剂学会致突变专业委员会委员、中国毒理学会表观遗传毒理专业委员会委员。主持国家自然基金（4项）、浙江省杰出青年基金、浙江省重点基金等项目10多项，骨干参与国家重点基金、国家重点研发计划课题、973计划课题、国家基金面上等国家级项目省重点研发等省重点项目多项。获江西省自然科学二等奖1项（排名第3）、浙江省自然科学三等奖1项（排名第2）。以第一或通讯作者在ACS Nano (IF 17.1), Gut Microbes (IF 12.2)，Environmental Science & Technology （IF 11.4）,Critical Reviews in Environmental Science and Technology （IF 12.6）， Journal of Advanced Research （IF 10.7），Journal of Hazardous Materials （IF 13.6）, Environment International （IF 11.8）, Environmental Pollution （IF 8.9）, Science of the Total Environment （IF 9.8），Toxicological Sciences（IF 3.8）等重要期刊上发表学术论文160余篇，发表的论文被Web of Science核心合集数据库论文引用超过10000次，H指数53。其中ESI热点论文2篇，ESI高被引论文20篇；谷歌学术引用13300余次，H指数62，i10指数130。多次入选由斯坦福大学与Elsevier发布的“年度科学影响力排行榜”榜单的全球前2%顶尖科学家（2023年度全球排名22704）；1篇论文入选由科技部中国科学信息研究所发布的2019年度中国百篇最具影响国际学术论文。研究成果被多次被“热心肠”、“微生态”以及浙江科技新闻网、浙江在线等媒体报道。担任Nat Commun, ACS Nano, Advanced Science,Environ Sci Technol, J Hazard Mater, Environ Int, Toxicol Sci, Environ Pollut, Sci Total Environ, Chemosphere, Environ Sci Technol Lett等十余种环境毒理与健康领域主流杂志的审稿人。

主持完成学校本科生分子生物学核心课程建设项目1项、研究生教改项目1项；主持在研研究生核心课程和双语课程各1项，发表教改论文1篇。同时承担生物工程学院研究生督导组的部分工作。

• 指导博士后1名（浙江树人大学副研究员），联合指导博士后2名

• 指导博士毕业生5名（分别就职于浙江树人大学副研究员、浙江省农科院助理研究员、长治医学院特聘教授、杭州师范大学教师、高新技术企业等）、硕士生毕业生20名（分别就职于杭州市疾控中心、温州市市场监督管理局、出国留学深造、中学教师、生物技术、生物制药相关高新企业等）

• 指导在读博士生8名、硕士生17名

• 指导研究生3人获校优秀硕士论文（徐启豪，2022；王晓芳，2023；徐海贵，2024）
  

• 指导博士生3人获得研究生国家奖学金（3万/每人）、硕士生17人次获得研究生国家奖学金（2万/每人）

• 指导研究生、本科生获得省挑战杯一等奖、三等奖多次

• 指导研究生陈汝家、张松彬获得浙江工业大学研究生十佳“学术之星”

• 指导本科生多次获得全国大学生生命科学创新创业大赛特等奖、一等奖、二等奖、三等奖10余项

• 指导本科生以第一作者发表SCI论文4篇

• 指导本科生2人获得国家奖学金（王小雨浙大直博、徐思怡北大直博）

• 获得优秀本科生指导教师（2019年）

• 获得浙江工业大学第十三届研究生“我心目中的好导师”称号（2023）

• 指导本科生20余人进入浙江大学、北京大学、清华大学、华东理工大学、暨南大学、浙工大等国内以及国外知名高校深造

  
  

  
  

主持科研项目：

11.浙江省重点研发项目（领雁）子课题，水产品中外源性化学危害物致毒机制与暴露评估, 2023-01至2025-12

10.国家自然基金面上项目，42277279，6PPD和微塑料联合暴露对斑马鱼心脏发育和功能影响的机理研究，2023-01至2026-12

9.省三农九方科技协作项目子课题，2022SNJF001，土壤生物功能解析与土壤健康评价技术构建,2022-01至2023-12

8.浙江省自然基金重点项目，LZ20B070002，基于对肠道微生态和屏障功能的影响研究新型全氟和多氟化合物对哺乳动物的毒性机理，2020-01至2023-12

7.国家自然科学基金面上项目，21777146，环境微塑料暴露引起斑马鱼肠道菌群失调导致行为和代谢紊乱的机理研究，2018-01至2021-12

6.农药等化学品的健康效应与安全评估，协作单位、企业横向项目多项，2020-01至2025-12

5.浙江工业大学一流高峰学科B类人才培育计划，2018-01至2019-12

4.浙江省杰出青年基金，LR16B070002，基于肠道菌群和脂质代谢变化研究环境相关浓度三种典型杀菌剂的毒理机制，2016-01至2019-12

3.国家自然科学基金面上项目，21277128，基于组蛋白甲基化表观遗传修饰研究芳香烃受体介导的致癌分子毒理机制，2013-01至2016-12

2.国家自然科学基金青年基金，21107098，手性农药氟氯菊酯在小鼠中选择性富集、代谢及内分泌干扰机理研究，2012-01至2014-12

1.浙江省自然基金一般项目，Y5090257，典型拟除虫菊酯农药对斑马鱼内分泌干扰效应及免疫毒性的分子机理研究，2010-01至2011-12

一、科研奖励

1. 浙江省自然科学三等奖，2021，排名第二

2. 江西省自然科学二等奖，2021，排名第三

3. 浙江省毒理学会科技（个人）奖, 2017

4. “十一五”浙江省自然科学基金优秀项目, 2011

二、近5年发表的代表性研究论文：

45. Qinglian Hu, Jiayu Feng, Lulu Qi, Yuanxiang Jin（靳远祥）*. Stromal Reprogramming Optimizes KRAS-specific Chemotherapy Inducing Antitumor Immunity in Pancreatic Cancer. ACS Applied Materials & Interfaces, 2024, Accepted

44. Shanshan Di, Haigui Xu, Yundong Yu, Peipei Qi, Zhiwei Wang, Zhenzhen Liu, Huiyu Zhao, Yuanxiang Jin（靳远祥）*, Xinquan Wang*. Environmental concentrations S-6PPD-quinone caused more serious hepatotoxicity than R- enantiomer and racemate in Oncorhynchus mykiss. Environmental Science & Technology. 2024, 58: 17617-17628

43. Caihong Wang, Qihao Xu, Chozhi Wei, Qinglian Hu, Yingping Xiao*, Yuanxiang Jin（靳远祥）*. Kynurenine attenuates ulcerative colitis by improving intestinal epithelial barrier and triggering AhR activation. Journal of Agricultural and Food Chemistry. 2024, 72:21000-21012

42. Hu QL, Li JY, Wang T, Xu XC, Duan YX, Jin YX (靳远祥)*. Polyphenolic Nanoparticle-Modified Probiotics for Microenvironment Remodeling and Targeted Therapy of Inflammatory Bowel Disease. ACS Nano. 2024, 18:12917-12932. (IF 17.1).

41. Wang WT, Luo T, Zhao Y, Yang XY, Wang D, Yang GL, Jin YX (靳远祥)*. Antibiotic resistance gene distribution in Shine Muscat grapes and health risk assessment of streptomycin residues in mice. Journal of Hazardous Materials, 2024, 465:133254. (IF 13.6)

40.Wang YH, Wang XF, Zhu YC, Wang D, Lv L, Chen LZ, Jin YX (靳远祥)*. Co-exposure ochratoxin A and triadimefon influenced the hepatic glucolipid metabolism and intestinal micro-environment in mice. Science of the Total Environment, 2024, 912:169339. (IF 9.8)

39. Fang CL, Di SS, Yu YD, Qi PP, Wang XQ, Jin YX (靳远祥)*. 6PPD induced cardiac dysfunction in zebrafish associated with mitochondrial damage and inhibition of autophagy processes. Journal of Hazardous Materials, 2024, 471:134357. (IF 13.6)

38.Jin YX (靳远祥)*, Wang JT, Xu HG, et al. Ecological and human health risk of aryl-phosphate flame retardants (APFRs): Sources, distribution, and toxicity. Critical Reviews in Environmental Science and Technology, 2023,1:21. (IF 12.6)

37. Xu HG, Wang JT, Wang QY, Tu WQ, Jin YX (靳远祥)*. Co-exposure to polystyrene microplastics and cypermethrin enhanced the effects on hepatic phospholipid metabolism and gut microbes in adult zebrafish. Journal of Hazardous Materials, 2024, 465:133051. (IF 13.6)

36.Zhang H, Wang JT, Qian MR, Jin YX (靳远祥)*. Mefentrifluconazole exposure disrupted hepatic lipid metabolism disorder tightly associated with gut barrier function abnormal in mice. Science of the Total Environment, 2023, 905:167317. (IF 8.9)

35.Tao HP, Wang JT, Bao ZW, Jin YX (靳远祥)*, Xiao YP. Acute chlorothalonil exposure had the potential to influence the intestinal barrier function and micro-environment in mice. Science of the Total Environment, 2023, 894:165038. (IF 8.9)

34.Huang ZZ, Weng Y, Shen QC, Zhao Y, Luo T, Xiao YP, Yang GL, Jin YX (靳远祥)*. Nano- and micro-polystyrene plastics interfered the gut barrier function mediated by exosomal miRNAs in rats. Environmental Pollution, 2023, 335:122275. (IF 8.9)

33.Bao ZW, Wang D, Zhao Y, Luo T, Yang GL, Jin YX (靳远祥)*. Insights into enhanced toxic effects by the binary mixture of carbendazim and procymidone on hepatic lipid metabolism in mice. Science of the Total Environment, 2023, 882:163648.  (IF 9.8)

32.Fang CL, Fang LY, Di SS, Yu YD, Wang XQ, Wang CH, Jin YX (靳远祥)*. Characterization of N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD)-induced cardiotoxicity in larval zebrafish (Danio rerio). Science of the Total Environment, 2023, 882:163595.  (IF 9.8)

31.Wang XF, Weng Y, Geng SN, Wang CY, Jin CY, Shi YL,*,Jin YX (靳远祥)*.Maternal procymidone exposure has lasting effects on murine gut-liver axis and glucolipid metabolism in offspring. Food and Chemical Toxicology, 2023, 174: 113657. (IF 5.572)

30. Fang LY, Fang CL, Di SS, Yu YD, Wang CH, Wang XQ*,Jin YX (靳远祥)*.Oral exposure to tire rubber-derived contaminant 6PPD and 6PPD-quinone induces hepatotoxicity in mice. Science of the Total Environment, 2023, 869: 161836. (IF 9.8)

29.Wang CH, Pan ZH, Jin YX (靳远祥)*.F-53B induces hepatotoxic effects and slows self-healing in ulcerative colitis in mice. Environmental Pollution, 2023, 317: 120819. (IF 8.9)

28.Shen QC, Huang ZZ, Ma LY, Yao JC, Luo T, Zhao Y, Xiao YP*,Jin YX (靳远祥)*.Extracellular vesicle miRNAs promote the intestinal microenvironment by interacting with microbes in colitis. Gut Microbes, 2022,14:2128604. (IF 12.2)

27.Wang YH, Weng Y, Lu Lv, Wang D, Yang GL, Jin YX (靳远祥)*, Wang Q*.Transgenerational effects of co-exposure to cadmium and carbofuran on zebrafish based on biochemical and transcriptomic analyses. Journal of Hazardous Materials, 2022, 403: 123688. (IF 13.6)

26.Shen QC, Xu BB, Wang CH, Xiao YP*, Jin YX (靳远祥)*. Bacterial membrane vesicles in inflammatory bowel disease. Life Sciences. 2022,306:120803. (IF 6.78)

25.Hu LY, Wang XF, Bao ZW, Qian MR*, Jin YX (靳远祥)*.The fungicide prothioconazole and its metabolite prothioconazole-desthio disturbed the bile acids metabolism and gut barrier function in mice. Chemosphere, 2022, 307: 136141 (IF 8.8) 

24.Wang XF, Hu LY, Wang CY, He BN, Fu ZW, Jin CY*, Jin YX (靳远祥)*.Cross-generational effects of maternal exposure to imazalil on anaerobic components and carnitine absorption associated with OCTN2 expression in mice. Chemosphere, 2022,308:136542. (IF 8.8)

23.Yang GL, Weng Y, Zhao Y, Wang D, Luo T, Jin YX (靳远祥)*.Transcriptomic and targeted metabolomic analysis revealed the toxic effects of prochloraz on larval zebrafish. Science of the Total Environment, 2022, 822: 153625. (IF 9.8)

22.Wang QY, Huang J, Liu S, Wang CY, Jin YX(靳远祥，通讯)*, Lai H, Tu WQ*. Aberrant hepatic lipid metabolism associated with gut microbiota dysbiosis triggers hepatotoxicity of novel PFOS alternatives in adult zebrafish. Environment International, 2022,166: 17351. (IF 13.352)

21.Di SS, Liu ZZ, Zhao HY, Li Y, Qi PP, Wang ZW, Xu H, Jin YX (靳远祥，通讯)*, Wang XQ* .Enantioselective toxicity of 6PPD and 6PPD-quinone to Oncorhynchus mykiss and Gobiocypris rarus, and enantioselective hydrolysis. Environment International, 2022, 166: 107374. (IF 11.8)

20.Zhang H, Qian MR, Wang JM, Yang GL, Weng Y, Jin CY, Li YH, Jin YX (靳远祥，通讯)*. Insights into the effects of difenoconazole on the livers in male mice at the biochemical and transcriptomic levels. Journal of Hazardous Materials, 2022, 403: 123688. (IF 13.6)

19.Shen QC, Huang ZZ, Yao JC, Jin YX (靳远祥，通讯)*. Extracellular Vesicles-mediated Interaction within Intestinal Microenvironment in Inflammatory Bowel Disease. Journal of Advanced Research, 2022, 37,221-233. (IF 12.822)

18.Jin CY, Yuan XL, Wang CY, Fu ZW, Jin YX (靳远祥，通讯)*. Maternal exposure to imazalil disrupts intestinal barrier and bile acids enterohepatic circulation tightly related IL-22 expression in F0, F1 and F2 generations of mice. Journal of Hazardous Materials, 2021, 403: 123688. (IF 13.6)

17.Wang YH, Jin CY, Wang D, Zhou JJ, Yang GL*, Shao K, Wang Q*, Jin YX (靳远祥，通讯)*. Effects of chlorothalonil, prochloraz and the combination on intestinal barrier function and glucolipid metabolism in the liver of mice. Journal of Hazardous Materials, 2021, 410: 124639. (IF 13.6)

16.Yang GL, Wang YH, Li J, Wang D, Bao ZW, Wang Q*, Jin YX (靳远祥，通讯)*. Health risks of chlorothalonil, carbendazim, prochloraz, their binary and ternary mixtures on embryonic and larval zebrafish based on metabolomics analysis. Journal of Hazardous Materials, 2021, 404: 124240. (IF 13.6)

15.Wang CY, Weng Y, Tu WQ*, Jin CY, Jin YX (靳远祥，通讯)*. Maternal exposure to sodium ρ-perfluorous nonenoxybenzene sulfonate during pregnancy and lactation disrupts intestinal barrier and may cause obstacles to the nutrient transport and metabolism in F0 and F1 generations of mice. Science of the Total Environment, 2021, 794: 148775. (IF 9.8)

14.Pan ZH, Miao WY, Wang CY, Tu WQ, Jin CY, Jin YX (靳远祥，通讯)*. 6:2 Cl-PFESA has the potential to cause liver damage and induce lipid metabolism disorders in female mice through the action of PPAR-γ. Environmental Pollution, 2021, 287: 117329. (IF 8.9)

13.Huang ZZ, Weng Y, Shen QC, Zhao Y, Jin YX (靳远祥，通讯)*. Microplastic: A potential threat to human and animal health by interfering with the intestinal barrier function and changing the intestinal microenvironment. Science of the Total Environment, 2021, 785: 147365. (IF 9.8)

12. Zhao Y, Qin Z, Huang ZZ, Bao ZW, Luo T, Jin YX (靳远祥，通讯)*. Effects of polyethylene microplastics on the microbiome and metabolism in larval zebrafish. Environmental Pollution, 2021, 282: 117039. (IF 8.9)

11. Weng Y, Huang ZZ, Wu AY, Yu QX, Lu HH, Lou Z, Lu LX, Bao ZW, Jin YX (靳远祥，通讯)*. Embryonic toxicity of epoxiconazole exposure to the early life stage of zebrafish. Science of the Total Environment, 2021, 778: 146407. (IF 9.8)

10.Yang GL, Yuan XL, Jin CY, Wang D, Wang YH*, Miao WY, Jin YX (靳远祥，通讯)*. Imidacloprid disturbed the gut barrier function and interfered with bile acids metabolism in mice. Environmental Pollution, 2020, 266: 115290. (IF 8.9)

9.Liu X, Zhang R, Jin YX (靳远祥，通讯)*. Differential responses of larval zebrafish to the fungicide propamocarb: Endpoints at development, locomotor behavior and oxidative stress. Science of the Total Environment, 2020, 731: 139136. (IF 9.8)

8.Bao ZW, Zhao Y, Wu AY, Lou Z, Lu HH, Yu QX, Fu ZW, Jin YX (靳远祥，通讯)*. Sub-chronic carbendazim exposure induces hepatic glycolipid metabolism disorder accompanied by gut microbiota dysbiosis in adult zebrafish (Daino rerio). Science of the Total Environment, 2020, 739: 140081. (IF 9.8)

7.Zhao Y, Bao ZW, Wan ZQ, Fu ZW, Jin YX (靳远祥，通讯)*. Polystyrene microplastic exposure disturbs hepatic glycolipid metabolism at the physiological, biochemical, and transcriptomic levels in adult zebrafish. Science of the Total Environment, 2020, 710: 136279. (IF 9.8)

6.Tao HP, Bao ZW, Jin CY, Miao WY, Fu ZW, Jin YX (靳远祥，通讯)*. Toxic effects and mechanisms of three commonly used fungicides on the human colon adenocarcinoma cell line Caco-2. Environmental Pollution, 2020, 263: 114660. (IF 8.9)

5.Yuan XL, Shen JY, Zhang XY, Tu WQ, Fu ZW, Jin YX (靳远祥，通讯)*. Imidacloprid disrupts the endocrine system by interacting with androgen receptor in male mice. Science of the Total Environment, 2020, 708: 135163. (IF 9.8)

4.Luo T, Wang CY, Pan ZH, Jin CY, Fu ZW, Jin YX (靳远祥，通讯)*. Maternal polystyrene microplastic exposure during gestation and lactation altered metabolic homeostasis in the dams and their F1 and F2 offspring. Environmental Science & Technology, 2019, 53: 10978-10992. (IF 11.4)

3.Luo T, Zhang Y, Wang CY, Wang XY, Zhou JJ, Shen ML, Zhao Y, Fu ZW, Jin YX (靳远祥，通讯)*. Maternal exposure to different sizes of polystyrene microplastics during gestation causes metabolic disorders in their offspring. Environmental Pollution, 2019, 255: 113122. (IF 8.9)

2.Pan ZH, Yuan XL, Tu WQ*, Fu ZW, Jin YX (靳远祥，通讯)*. Subchronic exposure of environmentally relevant concentrations of F-53B in mice resulted in gut barrier dysfunction and colonic inflammation in a sex-independent manner. Environmental Pollution, 2019, 253: 268-277. (IF 8.9)

1.Wang CY, Zhang Y, Deng M, Wang X, Tu WQ*, Fu ZW, Jin YX (靳远祥，通讯)*. Bioaccumulation in the gut and liver causes gut barrier dysfunction and hepatic metabolism disorder in mice after exposure to low doses of OBS. Environment International, 2019, 129: 279-290. (IF 11.8)