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更新时间：2026.04.03
总访问量：10
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柯淼林| 博士 助理研究员 硕士生导师 |
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单位： 职务： 无 研究方向： 办公地址： 子良楼A109 办公电话： 电子邮箱： kml_2021@zjut.edu.cn |
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柯淼林，博士，浙江工业大学绿色制药协同创新中心助理研究员，硕士生导师。2021.01 博士毕业于复旦大学有机化学专业；2021.01-2022.12 浙江工业大学从事博士后工作。2023.03 加入浙江工业大学绿色制药协同创新中心从事科研工作。主要从事药物合成及不对称催化方法学研究。近五年来，主持和参与国家自然科学基金、浙江省自然科学基金、横向共十项。以第一作者或通讯作者在ACS Catal.、Chem. Sci.、Org. Lett.、Chin. Chem. Lett.、Green. Synth. Catal.、Chem. Commun.、Org. Chem. Front.、Adv. Synth. Catal.等发表学术论文20篇。
研究方向一：不对称催化
采用双金属、金属/有机小分子协同催化策略，能够以碳酸酯为原料，高效生成含氧杂1,3-或1,5-偶极子过渡态。这类偶极子可在温和条件下原位形成，并与多种缺电子烯烃发生高效的[3+n]或[5+n]环加成反应，或与亲核试剂进行烯丙基取代反应。该过程不仅反应迅速，还能以优异的对映选择性构建具有高官能团密度的杂环化合物或手性烯丙基结构，为复杂分子的精准合成提供了新颖而高效的策略。
研究方向二：连续流反应研究
连续流反应技术在化学合成领域展现出巨大的潜力和广泛的应用前景，它显著提高了反应效率，同时确保了操作过程的安全性。更为重要的是，它在促进化学合成工艺向可持续性发展转型中发挥了关键作用。本课题组专注于端到端的连续流氢化、硝化、重氮化反应研究，并进一步探索喹诺酮类抗生素的全连续流合成技术。我们的目标是通过这一尖端技术，推动化学反应过程实现高效、环保和智能化的发展，为化学合成领域带来革命性的进步。
纵向项目
1. 浙江省自然科学基金，青基，10万，2026.1-2027.12， 主持
2. 国家自然科学基金，面上，50万，2026.1-2029.12，3/8， 参与
横向项目：
1. 一种精喹禾灵的全连续流制备方法，转化，20万，主持。
2. 右美沙芬连续流公斤级合成，100万，主持。
3. 合成氨基甘油的三步微反应工艺可行性验证实验，3万，主持。
4. NQYE合成技术研究，200万，参与 (完成人）。
5. 农药系列产品新工艺技术开发，120万，参与。
6. 高端精细化学品工艺技术开发，100万，参与。
7. 抗真菌原料药生物制备技术开发，100万，参与。
8. 阿伐他汀药物手性中间体A9的酶催化技术研究，100万，参与。
9. 三唑类药物手性中间体的生物催化技术开发，300万，参与。
发表论文：
21. Chen, B.; Xu, S.; Pan, Q.; Hong, R.; Zhu, W.; Liu, X.; Ke, M*.; Ju, Z*.; Chen, F*. Chemoenzymatic synthesis of mirabegron using an engineered styrene monooxygenase, Mol. Catal, 2026, 591, 115686.
20. Liu,H.; Zong, J.; Zhang, B.; Wang, J.; Zheng, G.; Ke, M*.; Chen, F*. Highly Regio- and Diastereoselective Construction of Spirocyclic Compounds via Palladium-Catalyzed [3+2] Cycloaddition of Vinyl Methylene Cyclic Carbonates with Pyrrolidinones, Org. Biomol. Chem., 2025, 23, 7951-7955.
19. Wang,D.; Zong, J.; Zhang, B.; Wang, J, Wang, B.; Piao, H.; Cheng, D.; Lin, J.; Ju, Z.*; Ke, M.*; Chen, F*.Enantioselective Synthesis of N-N Indole-Pyrrole Atropisomers via Palladium/Chiral Phosphoric Acid Relay Catalysis. ACS Catal, 2025, 15, 12450-12462.
18. Ke, M#.; Zheng, J#.; Zong, J.; Tang, K.; Wang, J.; Zheng, G.; Zhang, B.; Cheng, D.; Ju, Z*.; Chen, F*.Enantioselective [5+1] Cycloaddition of Sulfoxonium Ylides and Vinylethylene Carbonates via Synergistic Palladium/Chiral Phosphonic Acid Catalysis. Chem. Sci, 2025, 16，8108. (共同一作）
17.Tan, C.; Chen, Y.; Wu, J.; Li, M.; Cheng, D.; Ke, M*.; Chen, F*. Continuous Flow Synthesis of (E)-O-(3-chloro-2- propenyl)hydroxylamine: A Key Intermediate of Clethodim, J. Flow. Chem. 2025, 15, 79-88.
16. Wang, D.; Zong, J.; Wang, B.; Sun, L.; Xiao, X.; Piao, H.; Ke, M *.; Chen, F*. Asymmetric synthesis of allylic sulfonamides with axially and central chirality via palladium-catalyzed of atroposelective N-allylic alkylation. Green. Synth. Catal, 2025, 6, 211-215.
15. Ke, M.; Li, X.; Zong, J .; Wang, B.; Zheng, J.; Zhang, S.; Chen, J.; Chen, F*. Asymmetric Construction of Carbon-Fluorine Quaternary Stereogenic Centers via Synergistic Pd/Cu Catalysis. Org. Lett. 2024, 26, 1201-1206.
14. Wang,B.; Sun, L.; Cao, Q .; Li, X.; Chen, J.; Wang, S*.; Ke, M*.; Chen, F*.Cu-catalyzed three-component C-S-P coupling for the synthesis of trisubstituted allenyl phosphorothioates. Chin. Chem. Lett. 2024, 35, 109617.
13. Ke, M.; Yu, Y.; Sun, L .; Li, X.; Cao, Q.; Xiao, X*.; Chen, F*. Regio- and Stereoselective Syntheses of Chiral α-Quaternary (Z)-Trisubstituted Allylic Acids via Synergistic Palladium/Copper Catalysis.Chem. Commun. 2023, 59，2632-2635.
12. Yu, C.; Yu, Y.; Sun, L.; Li, X.; Liu, Z.; Ke, M*.; Chen, F*. Highly Diastereo- and Enantioselective Synthesis of Multisubstituted Allylic Amino Acid Derivatives by Allylic Alkylation of A Chiral Glycine-Based Nickel Complex and Vinylethylene Carbonates.
Org. Biomol. Chem. 2022, 20, 4894-4899.
11. Ke, M.; Qiao, B.; Yu, Y.; Li, X.; Xiao, X.; Li, S.; Lan, Y*.; Chen, F*. Palladium-Catalyzed Asymmetric [3 + 2] Annulation of Vinylethylene Carbonates with Alkenes Installed on Cyclic N-Sulfonyl Imines: Highly Enantio- and Diastereoselective Construction of Chiral Tetrahydrofuran Scaffolds Bearing Three Vicinal and Quaternary Stereocenters. J. Org. Chem. 2022, 87, 5166-5177.
10. Ke, M.; Yu, Y.; Zhang, K.; Zuo, S.; Liu, Z.; Xiao, X.; Chen, F*.Synergistic Pd/Cu Catalyzed Allylation of Cyclic Ketimine Esters with Vinylethylene Carbonates: Enantioselective Construction of Trisubstituted Allylic 2H-Pyrrole Derivatives. Adv. Synth. Catal. 2022, 364, 1849-1854.
9. Liu, D#.; Ke, M#.; Ru, T.; Ning, Y*.; Chen, F*. Room-Temperature Pd-Catalyzed Methoxycarbonylation of Terminal Alkynes with High Branched Selectivity Enabled by Bisphosphine-Picolinamide Ligand. Chem. Commun. 2022, 58, 1041-1044.（共一）
8. Ke, M.; Liu, Z.; Zhang, K.; Zuo, S.; Chen, F*. Synergistic Pd/Cu Catalysis for Stereoselective Allylation of Vinylethylene Carbonates with Glycine Iminoesters: Enantioselective Access to Diverse Trisubstituted Allylic Amino Acid Derivatives. Green. Synth. Catal. 2021, 2, 228-232.
7. Liu, Z#.; Ke, M.#; Zhang, K.; Wang, Z.; Ye, B*.; Chen, F*. Palladium-Catalyzed Allylation of Vinylethylene Carbonates with β-Ketophosphonates: Stereoselective Synthesis of (Z)-Homoallylic Phosphonates. ChemCatChem.2021, 13, 1753-1762.（共一）
6. Ke, M.; Liu, Z.; Huang, G.; Wang, J.; Tao, Y.; Chen, F*. Palladium-Catalyzed Regio- and Stereoselective Cross-Coupling of Vinylethylene Carbonates with Ketimine Esters to Generate (Z)-Tri- and Tetra-Substituted Allylic Amino Acid Derivatives. Org. Lett. 2020, 22, 4135-4140.
5. Ke, M.; Huang, G.; Ding, L.; Fang, J.; Chen, F*. Direct Synthesis of Substituted (Z)-Allylic Sulfones by Palladium-Catalyzed Sulfonylation of Vinylethylene Carbonates with Sodium Sulfinates. ChemCatChem.2019, 11, 4720-4724.
4. Ke, M.; Song, Q*.Copper-Catalyzed 1, 6-Hydrodifluoroacetylation of para-Quinone Methides at Ambient Temperature with Bis(pinacolato)diboron as Reductant. Adv. Synth. Catal. 2017, 359, 384-389.
3. Ke, M.; Song, Q*.Copper/B2pin2-Catalyzed C-H Difluoroacetylation-Cycloamidation of Anilines Leading to the Formation of 3, 3-Difluoro-2-oxindoles. Chem. Commun. 2017, 53, 2222-2225.
2. Ke, M.; Feng, Q.; Yang, K.; Song, Q*. Cu-Catalyzed Hydrofluoroacetylation of Alkynes or Alkynyl Carboxylic Acids Leading Highly Stereoselectively to Fluoroacetylated Alkenes. Org. Chem. Front., 2016, 3, 150-155.
1. Ke, M.; Song, Q*.Copper-Catalyzed C(sp2)-H Difluoroalkylation of Aldehyde Derived Hydrazones with Diboron as Reductant.J. Org. Chem. 2016, 81, 3654-3664.
授权专利：
1. 一种精喹禾灵的全连续流制备方法，：ZL 2025 1 0200067.8.
本科生制药设备与车间设计 辅讲
本科生现代仪器分析 主讲
柯淼林，博士，浙江工业大学绿色制药协同创新中心助理研究员，硕士生导师。2021.01 博士毕业于复旦大学有机化学专业；2021.01-2022.12 浙江工业大学从事博士后工作。2023.03 加入浙江工业大学绿色制药协同创新中心从事科研工作。主要从事药物合成及不对称催化方法学研究。近五年来，主持和参与国家自然科学基金、浙江省自然科学基金、横向共十项。以第一作者或通讯作者在ACS Catal.、Chem. Sci.、Org. Lett.、Chin. Chem. Lett.、Green. Synth. Catal.、Chem. Commun.、Org. Chem. Front.、Adv. Synth. Catal.等发表学术论文20篇。
研究方向一：不对称催化
采用双金属、金属/有机小分子协同催化策略，能够以碳酸酯为原料，高效生成含氧杂1,3-或1,5-偶极子过渡态。这类偶极子可在温和条件下原位形成，并与多种缺电子烯烃发生高效的[3+n]或[5+n]环加成反应，或与亲核试剂进行烯丙基取代反应。该过程不仅反应迅速，还能以优异的对映选择性构建具有高官能团密度的杂环化合物或手性烯丙基结构，为复杂分子的精准合成提供了新颖而高效的策略。
研究方向二：连续流反应研究
连续流反应技术在化学合成领域展现出巨大的潜力和广泛的应用前景，它显著提高了反应效率，同时确保了操作过程的安全性。更为重要的是，它在促进化学合成工艺向可持续性发展转型中发挥了关键作用。本课题组专注于端到端的连续流氢化、硝化、重氮化反应研究，并进一步探索喹诺酮类抗生素的全连续流合成技术。我们的目标是通过这一尖端技术，推动化学反应过程实现高效、环保和智能化的发展，为化学合成领域带来革命性的进步。
纵向项目
1. 浙江省自然科学基金，青基，10万，2026.1-2027.12， 主持
2. 国家自然科学基金，面上，50万，2026.1-2029.12，3/8， 参与
横向项目：
1. 一种精喹禾灵的全连续流制备方法，转化，20万，主持。
2. 右美沙芬连续流公斤级合成，100万，主持。
3. 合成氨基甘油的三步微反应工艺可行性验证实验，3万，主持。
4. NQYE合成技术研究，200万，参与 (完成人）。
5. 农药系列产品新工艺技术开发，120万，参与。
6. 高端精细化学品工艺技术开发，100万，参与。
7. 抗真菌原料药生物制备技术开发，100万，参与。
8. 阿伐他汀药物手性中间体A9的酶催化技术研究，100万，参与。
9. 三唑类药物手性中间体的生物催化技术开发，300万，参与。
发表论文：
21. Chen, B.; Xu, S.; Pan, Q.; Hong, R.; Zhu, W.; Liu, X.; Ke, M*.; Ju, Z*.; Chen, F*. Chemoenzymatic synthesis of mirabegron using an engineered styrene monooxygenase, Mol. Catal, 2026, 591, 115686.
20. Liu,H.; Zong, J.; Zhang, B.; Wang, J.; Zheng, G.; Ke, M*.; Chen, F*. Highly Regio- and Diastereoselective Construction of Spirocyclic Compounds via Palladium-Catalyzed [3+2] Cycloaddition of Vinyl Methylene Cyclic Carbonates with Pyrrolidinones, Org. Biomol. Chem., 2025, 23, 7951-7955.
19. Wang,D.; Zong, J.; Zhang, B.; Wang, J, Wang, B.; Piao, H.; Cheng, D.; Lin, J.; Ju, Z.*; Ke, M.*; Chen, F*.Enantioselective Synthesis of N-N Indole-Pyrrole Atropisomers via Palladium/Chiral Phosphoric Acid Relay Catalysis. ACS Catal, 2025, 15, 12450-12462.
18. Ke, M#.; Zheng, J#.; Zong, J.; Tang, K.; Wang, J.; Zheng, G.; Zhang, B.; Cheng, D.; Ju, Z*.; Chen, F*.Enantioselective [5+1] Cycloaddition of Sulfoxonium Ylides and Vinylethylene Carbonates via Synergistic Palladium/Chiral Phosphonic Acid Catalysis. Chem. Sci, 2025, 16，8108. (共同一作）
17.Tan, C.; Chen, Y.; Wu, J.; Li, M.; Cheng, D.; Ke, M*.; Chen, F*. Continuous Flow Synthesis of (E)-O-(3-chloro-2- propenyl)hydroxylamine: A Key Intermediate of Clethodim, J. Flow. Chem. 2025, 15, 79-88.
16. Wang, D.; Zong, J.; Wang, B.; Sun, L.; Xiao, X.; Piao, H.; Ke, M *.; Chen, F*. Asymmetric synthesis of allylic sulfonamides with axially and central chirality via palladium-catalyzed of atroposelective N-allylic alkylation. Green. Synth. Catal, 2025, 6, 211-215.
15. Ke, M.; Li, X.; Zong, J .; Wang, B.; Zheng, J.; Zhang, S.; Chen, J.; Chen, F*. Asymmetric Construction of Carbon-Fluorine Quaternary Stereogenic Centers via Synergistic Pd/Cu Catalysis. Org. Lett. 2024, 26, 1201-1206.
14. Wang,B.; Sun, L.; Cao, Q .; Li, X.; Chen, J.; Wang, S*.; Ke, M*.; Chen, F*.Cu-catalyzed three-component C-S-P coupling for the synthesis of trisubstituted allenyl phosphorothioates. Chin. Chem. Lett. 2024, 35, 109617.
13. Ke, M.; Yu, Y.; Sun, L .; Li, X.; Cao, Q.; Xiao, X*.; Chen, F*. Regio- and Stereoselective Syntheses of Chiral α-Quaternary (Z)-Trisubstituted Allylic Acids via Synergistic Palladium/Copper Catalysis.Chem. Commun. 2023, 59，2632-2635.
12. Yu, C.; Yu, Y.; Sun, L.; Li, X.; Liu, Z.; Ke, M*.; Chen, F*. Highly Diastereo- and Enantioselective Synthesis of Multisubstituted Allylic Amino Acid Derivatives by Allylic Alkylation of A Chiral Glycine-Based Nickel Complex and Vinylethylene Carbonates.
Org. Biomol. Chem. 2022, 20, 4894-4899.
11. Ke, M.; Qiao, B.; Yu, Y.; Li, X.; Xiao, X.; Li, S.; Lan, Y*.; Chen, F*. Palladium-Catalyzed Asymmetric [3 + 2] Annulation of Vinylethylene Carbonates with Alkenes Installed on Cyclic N-Sulfonyl Imines: Highly Enantio- and Diastereoselective Construction of Chiral Tetrahydrofuran Scaffolds Bearing Three Vicinal and Quaternary Stereocenters. J. Org. Chem. 2022, 87, 5166-5177.
10. Ke, M.; Yu, Y.; Zhang, K.; Zuo, S.; Liu, Z.; Xiao, X.; Chen, F*.Synergistic Pd/Cu Catalyzed Allylation of Cyclic Ketimine Esters with Vinylethylene Carbonates: Enantioselective Construction of Trisubstituted Allylic 2H-Pyrrole Derivatives. Adv. Synth. Catal. 2022, 364, 1849-1854.
9. Liu, D#.; Ke, M#.; Ru, T.; Ning, Y*.; Chen, F*. Room-Temperature Pd-Catalyzed Methoxycarbonylation of Terminal Alkynes with High Branched Selectivity Enabled by Bisphosphine-Picolinamide Ligand. Chem. Commun. 2022, 58, 1041-1044.（共一）
8. Ke, M.; Liu, Z.; Zhang, K.; Zuo, S.; Chen, F*. Synergistic Pd/Cu Catalysis for Stereoselective Allylation of Vinylethylene Carbonates with Glycine Iminoesters: Enantioselective Access to Diverse Trisubstituted Allylic Amino Acid Derivatives. Green. Synth. Catal. 2021, 2, 228-232.
7. Liu, Z#.; Ke, M.#; Zhang, K.; Wang, Z.; Ye, B*.; Chen, F*. Palladium-Catalyzed Allylation of Vinylethylene Carbonates with β-Ketophosphonates: Stereoselective Synthesis of (Z)-Homoallylic Phosphonates. ChemCatChem.2021, 13, 1753-1762.（共一）
6. Ke, M.; Liu, Z.; Huang, G.; Wang, J.; Tao, Y.; Chen, F*. Palladium-Catalyzed Regio- and Stereoselective Cross-Coupling of Vinylethylene Carbonates with Ketimine Esters to Generate (Z)-Tri- and Tetra-Substituted Allylic Amino Acid Derivatives. Org. Lett. 2020, 22, 4135-4140.
5. Ke, M.; Huang, G.; Ding, L.; Fang, J.; Chen, F*. Direct Synthesis of Substituted (Z)-Allylic Sulfones by Palladium-Catalyzed Sulfonylation of Vinylethylene Carbonates with Sodium Sulfinates. ChemCatChem.2019, 11, 4720-4724.
4. Ke, M.; Song, Q*.Copper-Catalyzed 1, 6-Hydrodifluoroacetylation of para-Quinone Methides at Ambient Temperature with Bis(pinacolato)diboron as Reductant. Adv. Synth. Catal. 2017, 359, 384-389.
3. Ke, M.; Song, Q*.Copper/B2pin2-Catalyzed C-H Difluoroacetylation-Cycloamidation of Anilines Leading to the Formation of 3, 3-Difluoro-2-oxindoles. Chem. Commun. 2017, 53, 2222-2225.
2. Ke, M.; Feng, Q.; Yang, K.; Song, Q*. Cu-Catalyzed Hydrofluoroacetylation of Alkynes or Alkynyl Carboxylic Acids Leading Highly Stereoselectively to Fluoroacetylated Alkenes. Org. Chem. Front., 2016, 3, 150-155.
1. Ke, M.; Song, Q*.Copper-Catalyzed C(sp2)-H Difluoroalkylation of Aldehyde Derived Hydrazones with Diboron as Reductant.J. Org. Chem. 2016, 81, 3654-3664.
授权专利：
1. 一种精喹禾灵的全连续流制备方法，：ZL 2025 1 0200067.8.
本科生制药设备与车间设计 辅讲
本科生现代仪器分析 主讲
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更新时间：2026.04.03
总访问量：10
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