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更新时间:2025.02.20
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凌飞

| 博士 副教授 博士生导师

单位:

职务: 药物化学与合成工艺研究所副所长

研究方向:

办公地址: 药学楼2A-317

办公电话:

电子邮箱: lingfei@zjut.edu.cn

手机访问
  • 个人简介

    凌飞 副研究员/博士生导师

      

        2016年6月获浙江大学有机化学专业博士学位,后在浙江工业大学从事博士后研究。2018年11月加入浙江工业大学药学院,现任副教授,博士生导师,药物化学与合成工艺研究所副所长,师生联合第一党支部书记,药学院钟为慧教授纵向团队德育导师,浙江省药学院会药物化学与抗生素专委会青年委员。主要从事药物及中间体的绿色合成工艺、手性配体与催化剂的开发、选择性碳氢键活化、有机电合成方法学研究,共发表SCI论文70多篇,以第一作者/通讯作者发表50多篇,包括J. Am. Chem. Soc.2)、Angew. Chem. Int. Ed.(1)Green Chem.8)、Org. Lett.3)、Org. Chem. Front.6)、Chem. Coummun.3)、Adv. Syn. Catal.10)、J. Org. Chem.7)等,封面论文和高被引论文各1篇。主持国家基金青年项目1项、国家自然科学基金面上项目2项、浙江省自然科学基金1项、省属高校科研业务费项目1项,博士后基金2项,主持或参与国家基金、省重点研发计划和企业横向20余项,以主要参与人参加抗击新冠病毒(2019-nCoV)肺炎应急科研专项—“瑞德西韦(Remdesivir)的创新工艺及产业化研究”,并成功实现公斤级量产。获授权中国专利25。入选浙江工业大学首届“星耀运河”学术新星(2023),浙江工业大学青年英才A类支持对象(2023),浙江工业大学高层次人才培育计划(2022),“南太湖精英计划”领军团队核心成员(2022),浙江工业大学台州研究院创新团队核心成员(2021)。



  • 教学与课程

    主讲本科生《生产实习A》、《制药工艺课程设计》,辅讲本科生《文献检索与专利》、硕士生《高等有机化学》、博士生《不对称催化研究进展》等课程。


  • 科研项目

    纵向课题情况

    序号

    项目名称

    起止时间

    项目级别/类型

    经费来源及额度

    担任角色

    是否结题

    1基于丰产金属“再生”策略的磷手性中心不对称构建及应用 22378363

    2024.01-

    2027.12

    国家级国家自然科学基金面上项目、50主持
    2丰产金属CoMn不对称催化氢化研究(RF-B2023008

    2024.01-

    2026.12

    厅局级浙江省高校基本科研业务费项目-B类项目、30万主持

    3

    二茂铁骨架+氮杂环卡宾构筑手性口袋策略调控锰催化不对称氢化反应22078298

    2021.01-

    2024.12

    国家级

    国家自然科学基金面上、65

    主持

    4

    边臂强化的手性二茂铁配体在钯催化合成手性γ-丁内酯(酰胺)中的应用研究(21706234)

    2018.01-

    2020.12

    国家级

    国家自然科学基金青年项目、25

    主持

    5

    电化学促进C-H精准官能团化及腺嘌呤先导化合物库的构建(LY21B020007

    2021.01-

    2023.12

    省部级

    浙江省自然科学基金、10

    主持

    6

    手性锰催化剂的设计、合成及其在不对称催化氢化中的应用研究

    2019.07-

    2022.12

    厅局级

    浙江省高校基本科研业务费项目-A类项目10

    主持

    7亚磺酰亚胺不对称电合成及其应用研究(2022M712824

    2022.03-

    2023.09

    省部级博士后科学基金委、8主持

    8

    基于氨基酸骨架的新型手性GAP试剂的设计、合成及应用

    2016.06-

    2019.09

    省部级

    博士后科学基金委、5

    主持

    9

    手性二茂铁PNN三齿配体的设计、合成及其在锰催化不对称催化氢化中的应用研究

    2019.05-

    2020.04

    院级

    药学院青年英才项目、5

    主持

    10

    无痕导向基促进的钴催化绿色插羰反应构建杂环化合物

    2017.05-

    2018.04

    院级

    药学院青年英才项目、5

    主持

    11

    基于二茂铁番骨架的新型手性FLP催化剂的设计、合成与应用(21676253

    2017.01-

    2020.12

    国家级

    国家自然科学基金、72

    参与

    12

    瑞德西韦(Remdesivir)的创新工艺及产业化研究

    2020.02-

    2020.07

    校级

    抗击新冠病毒(2019-nCoV)肺炎应急科研专项、100

    参与

    横向课题情况

    序号

    项目名称

    起止时间

    委托单位

    金额(万元)

    担任角色

    是否结题

    1医药中间体107F的合成工艺研究2023.03.20-2026.12.31江苏恒盛药业有限公司40主持

    2

    瑞卢戈利(Relugolix)创新合成工艺研究

    2021.11.16-2022.11.15

    诚达药业股份有限公司

    30

    主持

    3

    反式-1-3-甲氧基-2-哌啶基)-2-丙酮氢溴酸盐(Ridane HBr)合成工艺研究

    2020.08.25-

    2020.12.31

    诚达药业股份有限公司

    30

    主持

    4

    瑞格列净中间体的合成工艺开发

    2019.11.06-

    2022.11.05

    杭州杜易科技有限公司

    30

    主持

    5

    列净类原料药及医药中间体的合成工艺开发

    2018.01.01-

    2022.12.31

    江西华士药业有限公司

    60

    主要参与人(2/7)

    6

    3,4-二甲基吡唑磷酸盐(DMPP)和硫磷衍生物的绿色合成技术开发

    2018.07.01-

    2023.06.30

    浙江今晖新材料股份有限公司

    150

    主要参与人(2/5)

    7

    三唑类杀菌剂的合成工艺开发

    2020.06.01-

    2022.06.01

    江西华士药业有限公司

    60

    主要参与人(2/5)


     

  • 科研成果

    1. Dingguo Song, Weiwei Huang, Wenji Zhang, Changdi Zheng, Yuhua Chen, Jiayang Lv, Cunwei Zheng, Weihui Zhong,Fei Ling,* Synthesis of Non-C2-Symmetric Biaryldiols via Organo-Electro Catalyzed ArylAryl Dehydrogenative Cross-Coupling. J. Am. Chem. Soc., 2025, 147, 7524-7532.

    2. Lizhou Zheng, Weiqi Feng, Chen Chen, Ke Feng, Dingguo Song, Yirui Chen, Feiyang Shen, Xianghua Zhao, Fei Ling,* Weihui Zhong,* Development of Heterogeneous P-N-N Tridentate Ligand for Iridium-Catalyzed Asymmetric Hydrogenation of Ketones in Batch and Flow. Green Chem, 2025, DOI: 10.1039/d5gc00487j.

    3. Feiyang ShenLizhou ZhengKe FengYirui ChenMingming LiuDingguo Song, Fei Ling,* Weihui Zhong,* Polymer-covered SiO2 Composite: A New Strategy to Facilitate the Aqueous Asymmetric Transfer Hydrogenation. Adv. Syn. Catal., 2025, DOI: 10.1002/adsc.202401596.

    4. Min WangLei GaoMaozhong MiaoQianshou ZongFei Ling,* Jinzhong YaoHongwei Zhou,* Synthesis of 4-Cyclobutene-Isoquinolines From Aryl Imidates by Ru(II)-Catalyzed Domino C–H Activation/Cyclization. Appl. Organomet. Chem., 2025, 29, e7896.

    5. Zhenhui Xu, Changdi Zheng, Jie Lin, Weiweihuang, Dingguo Song, Weihui Zhong, Fei Ling,* Asymmetric Counteranion-Directed Electrocatalysis for Enantioselective Control of Radical Cation. Angew. Chem. Int. Ed., 2025, 64, e202413601.

    6. Tao LiuYan TangJiyuan Guo, YunfeiHang, Kali Zhang, Changdi Zheng, Weihui Zhong, Dingguo Song,Fei Ling,* Paired Electrocatalysis Enabled Cross Coupling of Sulfinamides with Olefins Towards Synthesis of Vinyl Sulfoximines. Org. Lett.2024268463-8467.

    7. Jiming Liu, Xinghua Zheng, Wenjun Luo, Zhengwang Chen,* Fei Ling,* TBAB-catalyzed assisted C-C/C-N bond formations: An efficient approach to dihydrobenzo[b][1,8]naphthyridin derivatives via metal free Cascade annulation. Synth. Commun., 2024, 54, 1252-1262.

    8. Xuying Xia, Changdi Zheng, Yunfei Hang, Jiyuan Guo, Tao Liu, Dingguo Song,  Zhiwei Chen, Weihui Zhong, Fei Ling,* Electrochemical enabled cobalt catalyzed enantioselective C-H acyloxylation of aryl phosphamide with carboxylic acid. Green Chem., 2024, 26, 8323-8329.

    9. Qian Tang, Dingguo Song, Kali Zhang, Wenhao Mao, Xianghua Zhao, Ding Du,* Fei Ling,* Weihui Zhong,* Development of an imidazole-based N,N-bidentate ligand for the manganese catalyzed direct coupling of nitriles with alcohols. RSC Adv., 2024, 14, 12978-12982.

    10. Wenhao Mao, Dingguo Song, Jiyuan Guo, Kali Zhang, Changdi Zheng, Jie Lin, Lian Huang, Lizhou Zheng, Weihui Zhong,* Fei Ling,* Manganese-Catalyzed Asymmetric Transfer Hydrogenation of Quinolines in Water using Ammonia Borane as a Hydrogen Source. Green Chem., 2024, 26, 5933-5939.

    11. Dingguo Song, Rong Chen, Weiwei Huang, Pengtao Yang, Lingxin Chen, Jialin Zhang, Fei Ling,* Weihui Zhong,* Room-Temperature Synthesis of α-Alkylated Indolin-2-ones via a Photo Assisted Iron Catalyzed Borrowing Hydrogen Reaction. Adv. Synth. Catal., 2024, 366,1893-1898.

    12. Pengtao Yang, Dingguo Song, Lingxin Chen, Xianghua Zhao, YiRui Chen, Feiyang Shen, Fei Ling,* Weihui Zhong*, Dynamic Kinetic Resolution of α-F-β-Ketone Amides (Esters) via Ir/f-Diaphos Catalyzed Asymmetric Hydrogenation. Org. Chem. Front., 2024, 11, 2201-2207.

    13. Dingguo Song, Changjun Zhang, Yuqi Cheng, Linlin Chen, Jie Lin, Changdi Zheng, Ting Liu, Yuxin Ding, Fei Ling*, Weihui Zhong,* Development of a more efficient catalyst for the redox-neutral organocatalytic mitsunobu reaction by DFT-guided catalyst design. Green Synth. Catal.2024, 5, 290-296.

    14. Tao Liu, Jie Lin, Fangjun Xia, Zhenhui Xu, Wei Qian, Weihui Zhong, Dingguo Song,* Fei Ling,* Electrochemical enabled desaturated β-C(sp3)-H sulfonylation and phosphonylation of cyclic amines, Green Synth. Catal.2024, 5, 297-302.

    15. Dingguo Song, Shiliang Wang, Weiwei Huang, Rong Chen, Fangyuan Hu, LingxinCheng, Xianghua Zhao, Fei Ling,*  Weihui Zhong,* Blue-Light Induced Iron-Catalyzed Chemoselective α-Alkylation and α-Olefination of Arylacetonitriles with Alcohols. Org. Chem. Front., 2023, 10, 5908-5915.

    16. Jiayin He, Wenhao Mao, Jie Lin, Yongzhen Wu, Lingxin Chen, Pengtao Yang, Dingguo Song, Peixi Zhu, Weihui Zhong, Fei Ling,* Enantioselective Synthesis of Chiral β-Hydroxy Sulfones via Manganese Catalyzed Asymmetric Hydrogenation. Org. Chem. Front., 202310, 3321-3327.

    17. Lei Liu, Zhenhui Xu, Jie Lin, Zhensheng Zhang, Yongzhen Wu, Pengtao Yang, Yunfei Hang, Dingguo Song, Weihui Zhong,* Fei Ling,* NHPI/O2-Mediated Electrochemical Intermolecular Cyclization/Dehydrogenation for the Construction of Polycyclic Quinazolinones,  Adv. Synth. Catal., 2023, 365, 2248-2254.

    18. Zhenhui Xu, Wangqin Zhang, Chao Xu, Tao Liu, Zhensheng Zhang, Changdi Zheng, Dingguo Song, Weihui Zhong, Fei Ling,* Ligand promoted cobalt catalyzed electrochemical C–H annulation of arylphosphinamide and alkyne. Adv. Synth. Catal., 2023, 365, 1877-1882.

    19. Tao Liu, Wangqin Zhang, Chao Xu, Zhenhui Xu, Dingguo Song, Wei Qian, Gang Lu, Chang-Jun Zhang, Weihui Zhong, Fei Ling,* Synthesis of P-stereogenic cyclicphosphinic amide via electrochemical enabled cobalt-catalyzed enantioselective CH annulation. Green Chem., 202325, 3606-3614.

    20. Yan Mao, Wenxi Chen, Changchang Li, Lin Miao, Yanfei Lin, Fei Ling,* Zhangpei Chen,* Jinzhong Yao,* Synthesis of 3,4,5-trisubstituted phenols via Rh(III)-catalyzed alkenyl C-H activation assisted by phosphonium cations. Chem. Commun.202359, 3775-3778.

    21. Shiliang Wang, Dingguo Song, Feiyang Shen, Rong Chen, Yuqi Cheng, Chuhan Zhao, Qilei Shen, Shuxin Yin, Fei Ling,* Weihui Zhong,* Manganese Catalyzed Cross-Coupling of Allylic Alcohols and Nitriles: An Elegant Route for Access of δ-Hydroxynitriles. Green Chem.202325, 357-364.

    22. Wenxi Chen, Yan Mao, Min Wang, Fei Ling,* Changchang Li, Zhangpei Chen,* Jinzhong Yao,* Rh(III)-catalyzed [4 + 1] cyclization of aryl substituted pyrazoles with cyclopropanols via C–H activation. Org. Biomol. Chem.202321, 775-782.

    23. Xianghua Zhao, Zehui Yang, Yuqi Cheng, An Huang, Fangyuan Hu, Fei Ling,* Weihui Zhong,* Divergent Synthesis of β-Hydroxy Amides (Esters) and γ-Amino Alcohols via Ir/f-Diaphos Catalyzed Asymmetric Hydrogenation. Adv. Synth. Catal., 2022, 364, 3074-3080.

    24. Lei Liu, Zhenhui Xu, Tao Liu, Chao Xu, Wangqin Zhang, Xiangqi Hua, Fei Ling,* Weihui Zhong,* Electrosynthesis of 2-Substituted Benzoxazoles via Intramolecular Shono-Type Oxidative Coupling of Glycine Derivatives. J. Org. Chem.202287, 11379-11386.(Highlighted by Organic Chemistry Portal)

    25. Chao Xu, Zhensheng Zhang, Tao Liu, Wangqin Zhang, Weihui Zhong, Fei Ling,* Hydrogen evolution-enabled rhodaelectro-catalyzed [4+2] annulations of purines and 7-deazapurines with alkynes. Chem. Commun.202258, 9508-9511.

    26. Yirui Chen, Xiao Yi, Yuqi Cheng, An Huang, Zehui Yang, Xianghua Zhao, Fei Ling,* Weihui Zhong,* Rh-Catalyzed Highly Enantioselective Hydrogenation of Functionalized Olefins with Chiral Ferrocenylphosphine-Spiro Phosphonamidite Ligands. J. Org. Chem.202287, 7864-7874. (Highlighted by Organic Chemistry Portal)

    27. Lei Liu, Wangqin Zhang, Chao Xu, Jiaying He, Zhenhui Xu, Zehui Yang, Fei Ling,* Weihui Zhong,* Electrosynthesis of CF3-Substituted Polycyclic Quinazolinones via Cascade Trifluoromethylation/Cyclization of Unactivated Alkene. Adv. Synth. Catal., 2022364, 1319-1325. (Most cited articles in Advanced Synthesis & Catalysis in 2024)

    28. Fei Ling,* Tao Liu, Chao Xu, Jiaying He, Wangqin Zhang, Changwu Ling, Lei Liu and Weihui Zhong,* Divergent Electrolysis for the Controllable Coupling of Thiols with 1,2-Dichloroethane: a Mild Approach to Sulfide and Sulfoxide. Green Chem.202224, 1342-1349. (2022年高被引论文)

    29. Xiao Yi, Yirui Chen, An Huang, Dingguo Song, Jiaying He, Fei Ling,* Weihui Zhong,* Design of Chiral Ferrocenylphosphine-spiro Phosphonamidite Ligands for Ruthenium-Catalysed Highly Enantioselective Coupling of 1,2-Diols with Amines.  Org. Chem. Front.,202186830–6836.

    30. Ze Wang, Xianghua Zhao, Shiliang Wang,An Huang, Yifan Wang, Jiaying He, Fei Ling,* Weihui Zhong,*Iridium/f-Diaphos Catalyzed Asymmetric Hydrogenation of 2-Imidazolyl Aryl Ketones. Org. Biomol. Chem.202119, 9746-9751.

    31. Fei Ling,* Yifan Wang, An Huang, Ze Wang, Shiliang Wang, Jiayin He, Xianghua Zhao, Weihui Zhong,* Iridium-Catalyzed Enantioselective and Diastereoselective Hydrogenation of Racemic β'-Keto-β-amino Esters via Dynamic Kinetic Resolution. Adv. Synth. Catal.,2021363, 4714-4719.

    32. Ze Wang, Xianghua Zhao, An Huang, Zehui Yang, Yuqi Cheng, Jiachen Chen, Fei Ling,* Weihui Zhong*, Manganese catalyzed enantio- and regioselective hydrogenation of a,ß-unsaturated ketones using an imidazole-based chiral PNN tridentate ligand. Tetrahedron Lett., 202182, 153389.

    33. Xiao Xiao, Bingxuan Shao, Jingyi Li, Zehui Yang, Yin-Jie Lu, Fei Ling, Weihui Zhong*, Enantioselective synthesis of functionalized 1,4-dihydropyrazolo-[4',3':5,6]-pyrano[2,3-b]quinolines through ferrocenyl-phosphine-catalyzed annulation of modified MBH carbonates and pyrazolones. Chem. Commun.,202157, 4690-4693.

    34. Fei Ling,* Didi Cheng, Tao Liu, Ze Wang, Chao Xu, Lei Liu, Yujin Li, Weihui Zhong*, Recyclable and Reusable n-Bu4NBF4/PEG-400/H2O System for Electrochemical C-3 Formylation of Indoles with Me3N as a Novel Carbonyl Source. Green Chem.202123, 4107-4113. (Highlighted by synfacts, 2021, 17, 1027)

    35. Dingguo Song, Linlin Chen, Tao Liu, Jiayin He, Chao Xu, Jingyi Li, Fei Ling,* Weihui Zhong*, Ruthenium Catalyzed α-Methylation of Sulfones with Methanol as a Sustainable C1 Source. Org. Chem. Front.,20218, 120-126.

    36. Haiwei Shen, Didi Cheng, Yujin Li, Tao Liu, Xiao Yi, Lei Liu, Fei Ling,* Weihui Zhong*, Late-Stage Diversification by Rutheniumelectro-Catalyzed C−H mono- and di-Acyloxylation. Green Synth. Catal.20201, 178-182.

    37. Haiwei Shen, Tao Liu, Didi Cheng, Chao Xu, Jiaying He, Yunfei Hang, Fei Ling,* Weihui Zhong,* Ruthenium-Catalyzed Electrochemical Synthesis of Indolines through Dehydrogenative [3+2] Annulation with H2 Evolution. J. Org. Chem.2020,85, 13735-13746.

    38. Wenjun Luo, BingXuan Shao, Jingyi Li, Xiao Xiao,Dingguo Song, Fei Ling, Weihui Zhong*, Construction of Spirooxindole-Fused Spiropyrazolones Containing Contiguous Three Stereogenic Centres via [3+2] Annulation Utilizing Ferrocene Derived Bifunctional Phosphine-Catalyst. Org. Chem. Front.2020,7, 1016-1021.

    39. Fei Ling,* Dingguo Song; Linlin Chen, Tao Liu, Mengyao Yu, Yan Ma, Lian Xiao, Min Xu, Weihui Zhong*, Synthesis ofN-Alkyl 2-Arylindole from Saturated Ketones and 2-Alkynylanilines via Cu-Catalyzed Sequential Dehydrogenation/aza-Michael Addition/Annulation CascadeJ. Org. Chem.2020, 85, 3224-3233.

    40. Fei Ling, Jiachen Chen, Sanfei Nian, Huacui Hou, Xiao Yi, Feifei Wu, Min Xu, Weihui Zhong, Manganese-Catalyzed Enantioselective Hydrogenation of Simple Ketones Using an Imidazole-Based Chiral PNN Tridentate Ligand. Synlett, 202031, 285-289.

    41. Chongren Ai, Haiwei Shen, Dingguo Song, Yujin Li, Xiao Yi, Ze Wang, Fei Ling,* Weihui Zhong,* Metal- and Oxidant-Free Electrochemical Synthesis of Sulfinic Ester via Sequential Oxidative S−H Bond Cleavage and Double S−O Bond Formation. Green Chem.201921, 5528-5531.

    42. Sanfei Nian,#Fei Ling,# Jiachen Chen, Ze Wang, Haiwei Shen, Xiao Yi, Yun-Fang Yang, Yuanbin She, Weihui Zhong,* Highly Enantioselective Hydrogenation of Non-ortho-Substituted 2-Pyridyl Aryl Ketones via Iridium-f-Diaphos Catalysis. Org. Lett.201921, 5392-5396.

    43. Fei Ling, Huacui Hou, Jiachen Chen, Sanfei Nian, Xiao Yi, Ze Wang, Dingguo Song, Weihui Zhong*,Highly Enantioselective Synthesis of Chiral Benzhydrols via Manganese Catalyzed Asymmetric Hydrogenation of Unsymmetrical Benzophenones using an Imidazole-Based Chiral PNN Tridentate Ligand. Org. Lett.201921(11), 3937-3941.

    44. Fei Ling, Zhen Xie, Jiachen Chen, Chongren Ai, Ze Wang, Haiwei Shen, Xiao Yi, Weihui Zhong*,Co balt(II)-Catalyzed [5+2] C-H Annulation of o-Arylanilines with Alkynes: An Expedient Route to Dibenzo-[b,d]azepinesAdv. Synth. Catal.2019361(13), 3094-3101.

    45. Wenjun Luo, Bingxuan Shao, Jingyi Li, Dingguo Song, Xiao Yi, Fei Ling, Weihui Zhong*, Divergent synthesis of spirocyclopentene-pyrazolones and pyrano[2,3-c]-pyrazoles via Lewis base controlled annulation reactions. Tetrahedron Lett., 201960(44), 151206.

    46. Fei Ling, Jiachen Chen, Zhen Xie, Huacui Hou, Zhentao Pan, Cong Feng, Haiwei Shen, Weihui Zhong*, Synthesis of substituted quinolines via B(C6F5)3-catalyzed aniline-aldehyde-pyruvate oxidative annulation, J. Heterocyclic Chem.,201956, 3333-3342.

    47. Zhentao Pan, Hui Wang, Fei Ling, Lian Xiao, Dingguo Song, Weihui Zhong*, Development of [3]ferrocenophane-derived N/B frustrated Lewis pairs for the metal-free catalytic hydrogenation of imines. Syn. Commun.201949522-528;

    48. Fei Ling, Lian Xiao, Lu Fang, Cong Feng, Zhen Xie, Yaping Lv, Weihui Zhong*, Metal Free B(C6F5)3-Catalyzed Markovnikov Addition of Indoles to Unactivated Alkynes. Org. Biomol. Chem.201816, 9274-9278.

    49. Fei Ling, Sanfei Nian, Jiachen Chen, Wenjun Luo, Ze Wang, Yaping Lv, Weihui Zhong*, Development of Ferrocene-Based Diamine-Phosphine-Sulfonamide (f-Diaphos) Ligands for Iridium Catalyzed Asymmetric Hydrogenation of Ketones. J. Org. Chem.201883, 10749-10761.

    50. Fei Ling, Chaowei Zhang, Chongren Ai, Yaping Lv, Weihui Zhong*, Metal Oxidant Free Cobalt Catalyzed C(sp2)-H Carbonylation of ortho-Arylanilines:An Approach Towards Free (NH)-Phenanthridinones. J. Org. Chem., 201883, 5698-5706.

    51. Zhentao Pan, Leixin Shen, Fei Ling, Weihui Zhong*, B(C6F5)3-catalyzed asymmetric reductive amination using NH3-BH3. J. Org. Chem., 201883, 11502-11509.

    52. Fei Ling, Lian Xiao, Lu Fang, Yaping Lv, Weihui Zhong*, Copper Catalysis for Nicotinate Synthesis through β-Alkenylation/Cyclization of Saturated Ketones with β-Enamino Esters. Adv. Synth. Catal.2018360, 444-448.

    53. Wenjun Luo, Dingguo Song, Lu Fang, Sanfei Nian, Huacui Hou, Fei Ling,Weihui Zhong*, Chiral Bifunctional Ferrocenylphosphine-Catalyzed Enantioselective Allylic Alkylation of Morita−Baylis−Hillman Carbonates with Pyrazolin-5-ones. Asian J. Org. Chem.,20187, 2417-2421.

    54. Fei Ling, Leixin Shen, Zhentao Pan, Lu Fang, Dingguo Song, Zhen Xie, Weihui Zhong*, B(C6F5)3-catalyzed oxidative deamination/cyclization cascade reaction of benzylamines and ketones for the synthesis of 2,4,6-triarylpyridines. Tetrahedron Lett.,201859, 3678-3682.

    55. Lu Fang, Liang QiLongfei YeZhentao PanWenjun LuoFei LingWeihui Zhong*, Dimethyl Sulfoxide-Accelerated Reductive Deamination of Aromatic Amines with T-BuONO in Tetrahydrofuran. J. Chem. Res., 2018,42, 579-583.

    56. Liang Qi, Huacui Hou, Fei Ling, Weihui Zhong,* The cinchona alkaloid squaramide catalyzed asymmetric Pictet–Spengler reaction and related theoretical studies. Org. Biomol. Chem.201816, 566-574.

    57. Fei Ling, Chongren Ai, Lv, Yaping, Weihui Zhong*, Traceless Directing Group Assisted Cobalt-Catalyzed C-H Carbonylation of Benzylamines. Adv. Synth. Catal.2017359, 3707-3712.

    58. Fei Ling, Chongren Ai, Yaping Lv, Weihui Zhong*, Formation of N-Unprotected Isoindolinones from Benzylamines via Cobalt-Catalyzed Traceless Directing Group-Assisted C(sp2)-H Carbonylation. Adv. Synth. Catal., 2017359, 3675.

    59. Wenjun Luo, Haiwen Hu, Sanfei Nian, Liang Qi, Fei Ling, Weihui Zhong,* Phosphine-catalyzed [3+2] annulation reaction: highly regio- and diastereoselective synthesis of 2-azaspiro[4.4]nonenes-1,3-dione. Org. Biomol. Chem., 2017, 157523-7526.

    60. 辉,郑亿,潘振涛,傅鸿樑,凌飞,钟为慧*受阻路易斯酸碱对催化氢化反应的研究进展有机化学201737(2), 301-313.

    61. Xuchun Zheng, Yanjun Wan, Fei Ling, Cheng Ma,* Copper-Catalyzed Tandem Reaction of Terminal Alkynes and Sulfonyl Azides for the Assembly of Substituted Aminotriazoles. Org. Lett.,201719, 3859-3862.

    62. Dong Cheng, Fei Ling, Chenguang Zheng, Cheng Ma,* Tuning of Copper-Catalyzed Multicomponent Reactions toward 3-Functionalized Oxindoles. Org. Lett.,201618, 2435-2438.

    63. Fei Ling, Yanjun Wan, Dongxu Wang, Cheng Ma,* Coupling and Decoupling Approach Enables Palladium-Catalyzed Aerobic Bimolecular Carbocyclizations of Enediynes to 2,6-Diacylnaphthalenes. J. Org. Chem., 201681, 2770-2781.

    64. Dongxu Wang, Fei Ling, Xiang Liu, Zexiang Li, Cheng Ma,* Aerobic Dimerization of Enediyne Compounds: Construction of Naphthalene Frameworks. Chem. Eur. J., 2016,22, 124-128.

    65. Xiaonan Yan, Fei Ling, Yuchen Zhang, and Cheng Ma,* Three-Component Functionalized Dihydropyridine Synthesis via a Formal Inverse Electron-Demand Hetero-Diels–Alder Reaction. Org. Lett., 201517, 3536-3539.

    66. Zexiang Li,#Fei Ling,# Dong Cheng, Cheng Ma,* Pd-Catalyzed Branching Cyclizations of Enediyne-Imides toward Furo[2,3-b]pyridines. Org. Lett.,201416, 1822-1825.

    67. Fei Ling, Zexiang Li, Chenguang Zheng, Xiang Liu, and Cheng Ma,* Palladium/Copper-Catalyzed Aerobic Intermolecular Cyclization of Enediyne Compounds and Alkynes: Interrupting Cycloaromatization for (4 + 2) Cross-Benzannulation. J. Am. Chem. Soc.,2014136, 10914-10917.

    68. Dong Cheng, Fei Ling, Zexiang Li, Weijun Yao, and Cheng Ma, Three-Component Assembly of Conjugated Enyne Scaffolds via E-Selective Olefination of Ynals. Org. Lett., 201214, 3146-3149.   

     


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