梁现蕊

梁现蕊，博士，副教授，国家化学原料药合成工程技术研究中心、绿色制药技术与装备教育部重点实验室、浙江省制药工程重点实验室骨干成员。主要从事药物及中间体、杂质质量分析与结构鉴定、中药活性成分分离分析技术与结构鉴定、药物活性成分体内外代谢、难溶中药化学成分增溶、中药小分子自组装纳米超分子开发、降血脂中药活性成分开发等领域的教学和研究工作，在Food Chemistry, International Journal of Pharmaceutics, LWT-Food Science and Technology, Journal of Molecular Liquids, Journal of Pharmaceutical and Biomedical Analysis, Journal of Separation Science等国际著名期刊上发表SCI论文60余篇，获授权发明专利10余项。主持国家自然科学基金项目1项，浙江省自然科学基金项目、浙江省科技计划项目等4项，作为主要成员，参与其他国家自然基金等省部级以上科研项目10余项。在横向科研工作方面，主持及参与完成横向科研项目10余项。作为主要完成人员获国家技术发明奖二等奖1项、浙江省科学技术奖一等奖2项，中国石油和化学工业协会技术发明一等奖2项和第十届中国专利优秀奖1项。立足教学科研一线，严谨治学，教书育人，已培养硕士研究生40余名。

立足教学科研一线，严谨治学，教书育人。主讲《药物分析》（双语）、《药物分析B》、《药物结构解析》（双语）、《药物分析实验》等本科生课程，以及《高等药物分析》、《药物结构解析》等研究生课程。在教学工作过程中围绕学生知识的学习与拓展为中心，针对教学内容特点及学生反馈情况，不断优化教学方式方法，积累了一定的教学实践经验，。曾自编《药学英语讲义》、《药物分析实验》讲义等。完成多项课程改革项目，并多次获优课优酬奖。

承担纵向科研项目：

1. 手性硫代咪唑啉酮/金属盐协同催化体系及其反应机理研究（21206148），国家自然科学基金项目，2013.01-2015.12，项目经费25万元；

2. 培南类药物及中间体质量改进技术研究（2012R10043-09），浙江省创新团队项目子项目，2012.04-2014.06，项目经费24万元；

3. 木芙蓉叶多维指纹图谱研究（2011C37036），浙江省分析测试科技计划项目，2011.01-2012.12，项目经费3万元。

承担横向科研项目：

  1.抗菌、抗心血管类药物及中间体、杂质的质量研究与开发，浙江海翔药业股份有限公司，2018.06-2023.6，200万元； 

  2.甾体激素类药物质量研究与相关技术开发, 浙江仙居君业药业有限公司,2017.01-2019.12, 30万元；

  3.抗菌、抗心血管类药物及中间体、杂质的质量研究与开发，浙江海翔药业股份有限公司，2014.07-2018.06，50万元；

4.培南类抗生素原料药及其中间体质量改进技术研究，浙江海翔药业股份有限公司/横向，2010.07-2014.06，100万元；

近年来代表性论文：

1.He Jiehong, Wang Tian, Xie Yuanyuan, Liang Xianrui*. Preparation and characterization of self-assembling nanoparticles in Gancao Ganjiang decoction. Journal of Molecular Liquids, 2024, 407, 125174. https://doi.org/10.1016/j.molliq.2024.125174

2. Su Yaxiu, Shen Luoyi, Zhu Peixi, Liang Xianrui*. UPLC-ESI-Q-TOF-MS/MS based metabolomics investigation on chemical constituent consistency of Zhenwu Decoction before and after compatibility. Journal of Pharmaceutical and Biomedical Analysis, 2024, 246, 116222. https://doi.org/10.1016/j.jpba.2024.116222

3. Guo Zili, Liu Yilin, Xiang Jiani, Liang Xianrui*. Mechanochemical preparation of red clover extract/β-cyclodextrin dispersion: Enhanced water solubility and activities in alleviating high-fat diet-induced lipid accumulation and gut microbiota dysbiosis in mice. Food Chemistry, 2023,  420, 136084. https://doi.org/10.1016/j.foodchem.2023.136084

4. Guo Zili, Chen Lisha, Liang Xianrui*. Components research on Tetrastigma hemsleyanum Diels et Gilg: Identification and effect of drying methods on the content of ten main constituents by targeting metabolomics method. Journal of Pharmaceutical and Biomedical Analysis, 2023, 229, 115375. https://doi.org/10.1016/j.jpba.2023.115375

5. He Yuanfan, Xiang Jiani, Chen Jie, Fang Sheng, Guo Zili, Liang Xianrui*. Improving bioaccessibility and bioavailability of isoflavone aglycones from chickpeas by germination and forming β-cyclodextrin inclusion complexes. Pharmaceutics, 2023, 15(12), 2684. https://doi.org/10.3390/pharmaceutics15122684

6. Guo Zili, Lai Jiangxuan, Wu Yiwen, Fang Sheng, Liang Xianrui*. Investigation on antioxidant activity and different metabolites of mulberry (Morus spp.) leaves depending on the harvest months by UPLC-Q-TOF-MS with multivariate tools. Molecules, 2023, 28(4), 1947. https://doi.org/10.3390/molecules28041947

7. Chen Zhehua, Ou Dong, Gu Gan, Gao Shumei, Li Xi, Hu Changwei, Liang Xianrui*, Zhang Yuejin. Removal of tetracycline from water by catalytic photodegradation combined with the microalga Scenedesmus obliquus and the responses of algal photosynthesis and transcription. Journal of Environmental Management, 2023, 326(Part A), 116693. https://doi.org/10.1016/j.jenvman.2022.116693

8. Gu, Gan, Dong Ou, Zhehua Chen, Shumei Gao, Shiqing Sun, Yongjun Zhao, Changwei Hu, Xianrui Liang*. Metabolomics Revealed the Photosynthetic Performance and Metabolomic Characteristics of Euglena gracilis under Autotrophic and Mixotrophic Conditions. World Journal of Microbiology & Biotechnology, 2022,  38 (9): 160. https://doi.org/10.1007/s11274-022-03346-w.

9. Han Ning, Ye Qin, Guo Zili, Liang Xianrui. Metabolomics analysis of differential chemical constituents and α-glucosidase inhibiting activity of Phyllanthus urinaria L. root, stem, leaf and fruit. Natural Product Research, 2023, 37(4), 642-645. https://doi.org/10.1080/14786419.2022.2069766

10. Guo, Zili, Shuting Xiong, Yuanyuan Xie, Xianrui Liang. The Separation and Purification of Ellagic Acid from Phyllanthus urinaria L. by a Combined Mechanochemical-Macroporous Resin Adsorption Method. Separations, 2021. 8 (10): 186. https://doi.org/10.3390/separations8100186.

11. Liang Xianrui, Jiang Yan, Guo Zili, Fang Sheng. Separation, UPLC-QTOF-MS/MS analysis, and antioxidant activity of hydrolyzable tannins from water caltrop (Trapa quadrispinosa) pericarps. LWT-FOOD SCIENCE AND TECHNOLOGY, 2020, 133: 110010. 

12.Guo Zili, Zhu Peixi, He Xiaoai, Yan Tianhe, Liang Xianrui*. Components identification and isomers differentiation in pigeon pea (Cajanus cajan L.) leaves by LC-MS.JOURNAL OF SEPARATION SCIENCE.2021,44(13): 2510-2523. DOI10.1002/jssc.202001194. (2021.7)

13.Wang Yeli, Deng Zian, Wang Xinmiao, Shi Yugang, Lu Ying, Fang Sheng*, Liang Xianrui*. Formononetin/methyl-fl-cyclodextrin inclusion complex incorporated into electrospun polyvinyl-alcohol nanofibers: Enhanced water solubility and oral fast-dissolving property. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2021, 603: 120696. DOI10.1016/j.ijpharm.2021.120696. (2021.6.15)

14. Xia Junjie, Guo Zili, Fang Sheng, Gu Jinping, Liang Xianrui*. Effect of Drying Methods on Volatile Compounds of Burdock (Arctium lappa L.) Root Tea as Revealed by Gas Chromatography Mass Spectrometry-Based Metabolomics. FOODS, 2021, 10(4): 868.

15. Gu Jinping，Shu Dan，Su Feng， Xie Yuanyuan， Liang Xianrui*. Analysis of metabolome changes in the HepG2 cells of apatinib treatment by using the NMR-based metabolomics.JOURNAL OF CELLULAR BIOCHEMISTRY, 2019, 120(11): 19137-19146. DOI10.1002/jcb.29242. (2019.11)

16. Jiang Xiuli, Chen Shihui, Guo Zili, Gu Dan, Liang Xianrui*. Components characterisation of Berchemia lineata (L.) DC. by UPLC-QTOF-MS/MS and its metabolism with human liver microsomes. NATURAL PRODUCT RESEARCH, 2019, 35(3): 521-524. DOI10.1080/14786419.2019.1637871. (2019.07)

17. Su Feng, Sun Ziqing, Su Weik, Liang Xianrui*. NMR investigation and theoretical calculations on the tautomerism of benzimidazole compounds. JOURNAL OF MOLECULAR STRUCTURE, 2018, 1173: 690-696. DOI10.1016/j.molstruc.2018.07.038. (2018.12.05)

18.  Wang Meilian, Fang Sheng, Liang Xianrui*. Natural deep eutectic solvents as eco-friendly and sustainable dilution medium for the determination of residual organic solvents in pharmaceuticals with static headspace-gas chromatography. 

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2018, 158: 262-268. DOI10.1016/j.jpba.2018.06.002. (2018.09.05)

19. Yu Dandan, Liang Xianrui*. Fragmentation pathways and differentiation of positional isomers of sorafenib and structural analogues by ESI-IT-MSn and ESI-Q-TOF-MS/MS coupled with DFT calculations. JOURNAL OF MASS SPECTROMETRY, 53(7): 579-589. DOI10.1002/jms.4192. (2018.07).

20. Xu Xiafen, Li Xinhui, Liang Xianrui*. Application of ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry in identification of three isoflavone glycosides and their corresponding metabolites. RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 2018,32(3): 262-268. DOI10.1002/rcm.8038. (2018.2.15)

获授权专利：

1. 梁现蕊，江燕. 一种从菱角壳中制备可水解单宁类粗提物的机械化学提取方法. ZL201910323318.6, 2021.01.26.

2. 梁现蕊，蒋秀丽. 一种从铁包金中制备萘吡喃酮粗提物的机械化学提取方法. ZL201910323824.5, 2020. 12.01.

3. 梁现蕊，苏为科，石飞，范骄阳. (S)型硫代咪唑啉酮类化合物催化不对称烷基化反应方法，ZL200910099864.2, 2011.12.21

4. 梁现蕊，金灿，潘冬明. 一种制备取代基脲联产相应胺盐酸盐的方法. ZL200810062129.X, 2011.02.02.

5. 梁现蕊，苏为科，石飞，范骄阳.一种(S)型硫代咪唑啉酮类化合物的制备方法. ZL200910099865.7, 2011.05.25

6. 梁现蕊，苏为科, 李峰，濮发祥，赖晓春，张建萍.一种1-氯甲酰基-4-哌啶基哌啶盐酸盐的化学合成法. ZL200610155214.1, 2009.06.03.