沈骥冬

沈骥冬，博士，浙江工业大学生物工程学院，助理研究员，主要从事酶工程与生物合成技术领域的研究与教学工作。长期聚焦于工业生物催化剂的理性设计与性能强化研究，在腈水合酶热稳定性机制解析、糖异构酶定向进化及生物信息学驱动酶分子设计等方向取得相关成果，近五年在ACS Catalysis、Critical Reviews in Biotechnology等国际权威期刊发表SCI论文10篇，获授权国家发明专利8项，主持企事业单位委托科技项目1项，其中多项酶分子改造技术实现工业化应用转化。现致力于开发新型生物催化体系在食品添加剂合成与生物质转化领域的技术突破，推动绿色生物制造产业发展。

[1] Shen J D, Cai X, Liu Z Q, et al. Nitrilase: a promising biocatalyst in industrial applications for green chemistry[J]. Critical Reviews in Biotechnology, 2021, 41(1): 72-93.

[2] Shen J D, Cai X, Ni Y W, et al. Structural insights into the thermostability mechanism of a nitrile hydratase from Caldalkalibacillus thermarum by comparative molecular dynamics simulation[J]. Proteins Structure Function and Bioinformatics, 2021, 89(8): 978-987.

[3] Shen J D, Cai X, Wang M, et al. Proposed mechanism for post-translational self-modification of Co-NHase based on Co²⁺ diffusion limitation[J]. Biotechnology Journal, 2021, 16(10): 2100103.

[4] Shen J D, Cai X, Liu Z Q, et al. High-throughput screening of signal peptide library with novel fluorescent probe[J]. Chembiochem, 2022, 23(12): e202100523.

[5] Shen J D, Xu B P, Yu T L, et al. Identification of hyperthermophilic D-allulose 3-epimerase from Thermotoga sp. and its application as a high-performance biocatalyst for D-allulose synthesis[J]. Bioprocess and Biosystems Engineering, 2024, 47(6): 841-850.