孙漩嵘

     副教授，博士生导师。主持国家重点研发项目子课题、国家自然科学基金-面上项目、青年项目以及省部级项目6项，参与国家自然科学基金项目10余项，主持企业横向1项。获协同中心、药学院青年英才项目滚动资助2项。在Adv. Mater. (2篇)、ACS Nano (1篇)、J. Am. Chem. Soc（1篇）、J. Med. Chem.（1篇）、Chem. Sci. (1篇）以及J. Control. Release（2篇）等国际顶级期刊上共发表论文50余篇，第一作者/通讯作者32篇，其中3篇为ESI高被引论文，共计引用2600次，授权专利2项。多篇论文发表后被Nat. Biomed. Eng.，JACS，JCM，J. Control. Release，PNAS，Adv. Mater.，Chem. Commun.以及ACS Nano 等高影响力期刊论文正面评述引用。

    主讲《人体解剖学》课程，连续五年获“优课优酬”奖励；先后完成4项校教改，入选校一流课程培育项目，2022年入选浙江省一流本科课程。

    目前担任浙江生命健康联合体青年委员会秘书长，中国肿瘤学纳米肿瘤学专委会青年委员，浙江省药理学会药理学教学专业委员会委员，中国药理学会会员、中国药学会会员、浙江省药学会会员、中国微米纳米技术学会会员，目前担任 J. Nanomedicine编委， Sci. Adv., J. Control. Release, Chem. Eng. J, Pharmaceutics, Biomater. Sci.以及 Expert. Opin. Drug. Deliv.的杂志审稿人。

 教育背景：

      2010.9--2014.6    浙江大学     生物化工  工学博士   导师：申有青教授

      2007.9--2010.6    上海第二军医大学 药理学   医学硕士   导师：姜远英教授

      2003.9--2007.6    中国药科大学   药学    理学学士   导师：王广基教授

  工作经历：

     2015.01-2016.08     浙江工业大学绿色制药协同创新中心      讲师

     2017.07-2017.08     美国University of California San Diego（加州大学圣地亚哥分校） 访问学者

     2017.10-2018.10    美国Johns Hopkins（约翰斯霍普金斯）大学   访问学者 （合作导师：Justin Hanes教授）

     2016.09-至今      浙江工业大学绿色制药协同创新中心     副教授

  研究方向：

     1. 基于仿生载体（蛋白、细胞）的药物递送系统用于抗肿瘤治疗的研究

     2. 新型抗感染药物递送系统的开发

     3. 抗肺纤维化药物递送系统的开发

本科生课程：

人体解剖学（双语）--浙江省一流本科课程
药理学（双语）

药代动力学（双语）

药理学实验

研究生课程：

实验安全与伦理

本科生参加科研项目：

1.15级本科生高梦诗、施国邦、叶心怡、郑敏子，运河杯项目“新型含氮杂环化合物体内外药效学活性及作用机制研究”“一种羟基喜树碱类衍生物纳米粒的制备方法”

2.17级本科生张秋琴、项佳妮，运河杯项目“难溶性药物的水溶性改善”

3.17级本科生张明炀、叶萌萌，运河杯项目“纳米辛伐他汀载药系统用于慢性阻塞性肺病模型的研究”

4.18级本科生何高锋、郑舒宁、李泽茹，运河杯项目“多肽修饰的聚合物胶束的构建及表征”

5.18级本科生高鑫、徐佳能、王逸曦，运河杯项目“微流控制备共载药聚合物纳米脂质体及其表征”

6.18级本科生应乐熠、张欣睿，运河杯项目“不同粒径的载药纳米胶束的微流控制备及表征”

4.19级本科生刘昊华、褚雨腾、余小杰，运河杯项目“金黄霉素A乳膏剂的研究和制备”

5.19级本科生夏闻阳、兰涵悦，运河杯项目“多肽修饰的巨噬细胞膜仿生递药系统的制备与表征”

本科生作为第一作者发表论文：

1.高梦诗（15级本科生），郑敏子，叶心怡，施国邦，阙祥洁，张隆超，孙漩嵘，一种新型二氢吡唑类衍生物的体外抑瘤作用及机制，中国药理学与毒理学杂志，2018,3,8 

2.Haohua Liu（19级本科生）, Yue Cai, Yuteng Chu, Xiaojie Yu, Fuhang Song, Hong Wang, Huawei Zhang and Xuanrong Sun, Formulation of Chrysomycin A Cream for the Treatment of Skin Infections, Molecules, 27, 4613, 2022

3. Qianyu Wan（20级本科生）, Xinrui Zhang, Dongfang Zhou, Rui Xie, Yue Cai, Kehao Zhang, Xuanrong Sun, Inhaled nano-based therapeutics for pulmonary fibrosis: recent advances and future prospects. Journal of Nanobiotechnology, 2023, accepted.

本科生申请专利：

一种羟基喜树碱类衍生物脂质体的制备方法。申请专利号：201910285625.X

获奖荣誉：

17级研究生蔡悦获2018年度国家奖学金荣誉

18级研究生徐卓敏获2021年度校级优秀毕业生

19级研究生郑珊珊获2022年度校级优秀硕士论文

20级研究生洪煜璐获2021年度、2022年度国家奖学金荣誉

20级研究生龚喻贝、洪煜璐获2023年省级优秀毕业生称号

20级本科生万千语获2023年国家奖学金荣誉

21级研究生林梦霞获2023年浙江省专业学位研究生优秀实践成果奖

1. 受体介导的巨噬细胞膜仿生递药系统用于双级靶向治疗脑胶质瘤的研究，国家自然科学基金面上项目，2021.1-2024.12，在研，主持。

2. 铁蛋白介导的纳米载药系统用于脑胶质瘤的治疗，浙江省公益技术研究计划，2021.1-2023.12，主持，已结题。

3. 海洋微生物药物候选物的高效发现与创制，国家重点研发计划，2018.12-2021.12，已结题，“先导物早期安全性评价及初步剂型研究”子课题负责人。

4. 一种治疗肺纤维化新药临床前研究，丽水经济开发区重点研发计划项目, 2022.1-2024.12，企业横向，在研。

5. 药学专业“人体解剖学”中课程思政融入教学初探。浙江工业大学校级教改，2021.6-2023.6，主持，已结题。

6. “人体解剖学”, 浙江工业大学一流课程培育，2022.1-2023.12，主持，已结题。

7. ATF3在砷致支气管上皮细胞损伤、恶性转化和EMT中的作用及机制，国家自然科学基金，2018.1-2020.12，参与。

8．巨噬细胞输送纳米药物靶向乳腺癌缺氧部位的抗肿瘤活性研究，国家自然科学基金，2016.1-2018.12，主持，已结题。

9．巨噬细胞介导的新型抗癌药物输送体系的构建及其应用研究，浙江省自然科学基金，2016.1-2018.12，主持，已结题。

10. 药学专业“人体解剖组织学”现代教学方法与实践教学方法的应用。浙江工业大学校级教改, 2017.1-2018.12，主持，已结题。

11. 可降解型树枝状大分子用于肿瘤细胞核靶向药物输送研究，国家自然科学基金，2012.1-2014.12，参与，已结题。

12. 以天然药物-没食子酸为基元构筑可降解树枝状大分子多功能载体的研究，国家自然科学基金，2013.1-2015.12，参与，已结题。

论文发表：

1. Xuanrong Sun*, Tenghan Zhang, Zhao Lou, Yujie Zhou, Yuteng Chu, Dongfang Zhou, Juhong Zhu, Yue Cai, Jie Shen*. A size shrinkable dendrimer-lipid hybrid nanoassembly for reversing tumor drug resistance. Green Chemical Engineering. 2024, in press.

2. Wan, Qianyu, Sun Yuji, Sun Xuanrong*, Zhou Zhuxian*. Rational design of polymer-based mRNA delivery systems for cancer treatment. Polymer Chemistry. 2024, in press.

3. Jingyi Lu, Xiaoling Xu, Xuanrong Sun*, Yongzhong Du*, Protein and Peptide-Based Renal Targeted Drug Delivery Systems, Journal of Controlled Release. 2024, 366: 65-84

4. Qiwen shi, Mengxia Lin, Xiang Cheng, Ziyuan Zhang, Shufen Deng, Ke Lang, Zhikun Yang, Xuanrong Sun^#. KPNB1-mediated nuclear import in cancer. European Journal of Pharmacology, 2023, 15;955:175925

5. Yue Cai, Yuteng Chu, Yubei Gong, Yulu Hong, Fuhang Song, Hong Wang, Huawei Zhang, Xuanrong Sun^#.  Enhanced Transdermal Peptide-Modified Flexible Liposomes for Efficient Percutaneous Delivery of Chrysomycin A to Treat Subcutaneous Melanoma and Intradermal MRSA Infection. Advanced Healthcare Materials, 2023, 12(26):e2300881

6. Qianyu Wan, Xinrui Zhang, Dongfang Zhou, Rui Xie, Yue Cai, Kehao Zhang, Xuanrong Sun^#, Inhaled nano-based therapeutics for pulmonary fibrosis: recent advances and future prospects. Journal of Nanobiotechnology, 2023, 21(1):215. 

7. Feihu Wang, Hao Su, Zeyu Wang, Caleb F. Anderson, Xuanrong Sun, Han Wang, Philippe Laffont, Justine Hanes*, Honggang Cui*, Supramolecular Filament Hydrogel as a Universal Immunomodulator Carrier for Immunotherapy Combinations, ACS Nano, 2023,17,11,10651-10664.

8. Zhikun Yang, Yue Cai, Xue Yang, Xuanrong Sun^# et al. Novel Benzo Five-Membered Heterocycle Derivatives as P-Glycoprotein Inhibitors: Design, Synthesis, Molecular Docking, and Anti-Multidrug Resistance Activity[J]. J. Med. Chem. 2023, 66, 8, 5550–5566.

9. Zhikun Yang, Xue Yang, Yasheng Li, Yue Cai, Yanlei Yu, Wenya Zhuang, Xuanrong Sun et al. Discovery of 2,5-disubstituted furan derivatives featuring a benzamide motif for overcoming P-glycoprotein mediated multidrug resistance in MCF-7/ADR cell[J]. European Journal of Medicinal Chemistry, 2023, 257, 5, 115462.

10. 郑珊珊，蔡悦，龚瑜贝，洪煜璐，孙漩嵘*，纳米载体用于包载生物活性多肽的研究，中国生物医学工程学报，2023,42,1
    

11. Wang Yi, Wang Wenchao, Yu Endian, Zhuang Wenya, Sun Xuanrong, Wang Hong, Li Qingyong, Preparation of a camptothecin analog FLQY2 self-micelle solid dispersion with improved solubility and ADME properties, Journal of Nanobiotechnology, 2022, 5; 20(1):402

12. Wang Yi, Zhang Xiangli, Zhuang Wenya, Yu Yanlei, Sun Xuanrong, Wang Hong, Li Fengzhi, Li Qingyong, Investigation of the Uptake and Transport of Two Novel Camptothecin Derivatives in Caco-2 Cell Monolayers, Molecules, 2022, 27, 12.

13. Chen Yan, Liu Pengfu, Wu Jiequn, Yan Wanqing,Xie Saixue, Sun Xuanrong, Ye Bangce, Chu Xiaohe, N-acylhomoserine lactonase-based hybrid nanoflowers: a novel and practical strategy to control plant bacterial diseases, Journal of Nanobiotechnology, 2022, 20, 1
    

14. Mengxue Wei, Si-si Zhang, Xuanrong Sun, Yang Ji, Pei-wen Yang, Xue-Qiang Li,Design, Synthesis, and Biological Evaluation of Artemisinin-Piperazine-Phosphoramide Mustard Hybrids as Potential Anticancer Agents. ChemMed Chem. 2022, accepted.

15. Mengxue Wei, Yixuan Zhou, Mengxia Lin, Jun Zhang, Xuanrong Sun*, Design, synthesis and biological evaluation of rhein-piperazine-dithiocarbamate hybrids as potential anticancer agents. European Journal of Medicinal Chemistry. 2022, 241(5), 114651

16. Haohua Liu, Yue Cai, Yuteng Chu, Xiaojie Yu, Fuhang Song, Hong Wang, Huawei Zhang, Xuanrong Sun*, Formulation of Chrysomycin A Cream for the Treatment of Skin Infections,Molecules 2022, 27, 4613.

17. Shanshan Zheng, Yue Cai, Yubei Gong, Yulu Hong, Licheng Gao, Le Li, Xuanrong Sun*, Legumain/pH Dual-Responsive Lytic Peptide-Paclitaxel Conjugate for Synergistic Cancer Therapy, Drug Delivery, 2022, 29:1, 1764-1775

18. Dabu Zhu, Qiuqin Zhang, Yifang Chen, Minghua Xie, Jianbo Li, Shen Yao, Ming Li, Zhao Lou, Yue Cai, Xuanrong Sun*,  Mechanochemical preparation of triptolide-loaded self-micelle solid dispersion with enhanced oral bioavailability and improved anti-tumor activity, Drug Delivery. 2022, 29:1,1398-1408

19. 龚喻贝，李少广，洪煜璐，谢德晖，郑珊珊，孙漩嵘*，应用纳米技术调控微生物组治疗癌症的研究进展，药学学报，2022,57(4):952-962

20. Feihu Wang, Hao Su, Dongqing Xu, Maya K. Monroe, Caleb F.Anderson, Weijie Zhang, Richard Oh, Zongyuan Wang, Xuanrong Sun, Han Wang, Fengyi Wan, Honggang Cui. Therapeutic supramolecular tubustecan hydrogel combined with checkpoint inhibitor elicits immunity to combat cancer. Biomaterials. 2021,279

21.  Zhuomin Xu, Shanshan Zheng, Xin Gao, Yulu Hong, Yue Cai, Qiuqin Zhang, Jiani Xiang, Dehui Xie, Fuxing Song, Huawei Zhang, Hong Wang and Xuanrong Sun*, Mechanochemical preparation of chrysomycin A self-micelle solid dispersion with improved solubility and enhanced oral bioavailability. Journal of Nanobiotechnology, 19:164, 2021

22. Xuanrong Sun*, Yulu Hong, Yubei Gong, Shanshan Zheng and Dehui Xie, Bioengineered Ferritin Nanocarriers for Cancer Therapy.  International Journal of Molecular Sciences, 22,7023, 2021

23. Xuanrong Sun, Tianwei Zhang , Yue Cai, Ke Yang, Tingting Peng, Renhao Liu and Xing-Nuo Li, Tonkinensine B induces apoptosis through mitochondrial dysfunction and inactivation of the pI3K/Akt pathway in triple-negative breast cancer cells. Journal of Pharmacy and Pharmacology, 73, 10, 1397-1404, 2021.

24. Liu Renhao, Bao Xiaoze, Sun Xuanrong, Cai Yue, Zhang Tianwei, Ye Xinyi, Li Xingnuo, Cytisine-flavonoid conjugates: Synthesis and antitumor structure-activity relationship research, Tetrahedron Letters, 2020, 61, 17.

25. Qi Shuai, Yue Cai, Guangkuo Zhao, Xuanrong Sun*, Cell-penetrating peptide modified PEG-PLA micelles for efficient PTX delivery. International Journal of Molecular Sciences, 21(1856), 2020

26. Yue Cai, Zhuomin Xu, Qi Shuai, Fangtao Zhu, Jiao Xu, Xin Gao, Xuanrong Sun*, Tumor-targeting peptide functionalized PEG-PLA micelles for efficient drug delivery. Biomaterial Science, 15;8:2274-2282, 2020.

27. Wang, F.; Xu, D.; Su, H.; Zhang, W.; Sun, X.; Monroe, M.; Chakroun, R.W.; Wang, Z.; Dai, W.; Oh, R.; Wang, H.; Wan, F.; Cui, H., Supramolecular prodrug hydrogelator as an immune booster for checkpoint blocker-based immunotherapy. Science Advances, 6(18):eaaz8985, 2020.

28. 孙漩嵘，徐卓敏，蔡悦，微流控技术在纳米药物载体制备中的应用，中国药学杂志，55(8), 2020.

29. Xuanrong Sun*, Yue Cai, Zhuomin Xu and Dabu Zhu，Preparation and Properties of Tumor-Targeting MRI Contrast Agent Based on Linear Polylysine Derivatives. Molecules, 24(1477), 2019.

30. Xuanrong Sun*, Dabu Zhu, Yue Cai, Guobang Shi, Mengshi Gao, Minzi Zheng. One-step mechanochemical preparation and prominent antitumor activity of SN-38 self-micelle solid dispersion. International journal of nanomedicine, 14(2115-2126), 2019.

31. Xuanrong Sun*, Longchao Zhang*, Mengshi Gao, Xiangjie Que, Chenfeng Zhou, Dabu Zhu and Yue Cai. Nanoformulation of a Novel Pyrano[2,3-c] Pyrazole Heterocyclic Compound AMDPC Exhibits Anti-Cancer Activity via Blocking the Cell Cycle through a P53-Independent Pathway. Molecules, 24(624), 2019. 

32. Xinglu Huang, Jie Zhuang, Seung Woo Chung, Buwei Huang, Gilad Halpert, Karina Negron, Xuanrong Sun, Jun Yang, Yumin Oh, Paul M. Hwang, Justin Hanes and Jung Soo Suk. Hypoxia-tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-Associated Hypoxia. ACS Nano,13,236-247, 2019.

33. Ting-Ting Peng, Xuanrong Sun, Ren-Hao Liu, Lu-Xia Hua, Dong-Ping Cheng, Bin Mao and Xing-Nuo Li. Cytisine-Pterocarpan Derived Compounds: Biomimetic Synthesis and Apoptosis-Inducing Activity in Human Breast Cancer Cells. Molecules, 23(3059), 2018.

34. Xuanrong Sun*, Guowei Wang*, Hao Zhang, Shiqi Hu, Xin Liu, Jianbin Tang and Youqing Shen. The Blood Clearance Kinetics and Pathway of polymeric micelles in cancer drug delivery. Acs Nano, 12(6), 6179-6192, 2018. 

35. Xuanrong Sun, Dabu Zhu, Yue Cai, Macrophages Mediated Biomimetic Drug Delivery Systems, Journal of nanomedicine, 1(1), 2018.

36. Zhangdan Huang*, Xuanrong Sun*, Xuanrong Sun, Xiangrui Liu, Youqing Shen, Kai Wang. Macrophages as an active tumor-targeting carrier of SN38-nanoparticles for cancer therapy. Journal of drug targeting, 26(5-6), 458-465, 2018.

37. 高梦诗，郑敏子，叶心怡，施国邦，阙祥洁，张隆超，孙漩嵘*。一种新型二氢吡喃并［2，3-c］吡唑类衍生物的体外抑瘤作用及机制，中国药理学与毒理学杂志，32（8），614-620，2018。

38. 孙漩嵘，张隆超，施绮雯，李汉兵，赵航。细胞−纳米药物递送系统的研究进展，药学学报，52（7），1110-1116，2017。

39. Xuanrong Sun, Longchao Zhang, Macrophage-mediated delivery of microparticles into tumor hypoxia zones. Journal of Controlled Release, 259，e159, 2017.

40. Xiaoman Mao, Jingxing Si, Qian Huang, Xuanrong Sun, Qianzhi Zhang, Youqing Shen, Jianbin Tang, Xiangrui Liu, Meihua Sui. Self-Assembling Doxorubicin Prodrug Forming Nanoparticles and Effectively Reversing Drug Resistance In Vitro and In Vivo. Advanced Healthcare Materials, 5, 2517-2527, 2016. 

41. Xuanrong Sun, Shao Shiqun, Shen Youqing, Cascade-released Nanoassembly for Cancer Drug Delivery. Nanomedicine, 12(2):471-472, 2016. 

42. Xumeng Wu*, Xuanrong Sun*, Zhiqian Guo, Jianbin Tang, Youqing Shen, Tony D James, He Tian, Weihong Zhu, In Vivo and In Situ Tracking Cancer Chemotherapy by Highly Photostable NIR Fluorescent Theranostic Prodrug. Journal of the American Chemical Society, 136(9), 2579-2588, 2014. 

43. Qihang Sun*, Xuanrong Sun*, Xinpeng Ma, Zhuxian Zhou, Erlei Jin, Bo Zhang, Youqing Shen, Edward A Van Kirk, William J Murdoch, Joseph R. Lott, Timothy P. Lodge, Maciej Radosz and Yuliang Zhao, Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs. Advanced Materials, 26(45):7615-21, 2014.

44. Jingqiang Wang*, Xuanrong Sun*, Meihua Sui, Jianbin Tang, Youqing Shen. Tumor Redox Heterogeneity-Responsive Prodrug Nanocapsules for Cancer Chemotherapy. Advanced Materials, 25, 3670-3676, 2013. 

45. Xumeng Wu*, Shu Chang*, Xuanrong Sun*, Zhiqian Guo, Yongsheng Li, Jianbin Tang, Youqing Shen, Jianlin Shi, He Tian, Weihong Zhu, Constructing Near-infrared Silica-Cyanine Hybrid Nanocomposite for in vivo Bioimaging: A Breakthrough in Photo-Stability and Bright Fluorescence with Large Stokes Shift of Cyanine via Encapsulation. Chemical Science, 4, 1221-1228, 2013. 

46. Xuanrong Sun, Hui Lu, Yuanying Jiang, Yingying Cao, CaIPF19998 Reduces Drug Susceptibility by Enhancing the Ability of Biofilm Formation and Regulating Redox Homeostasis in Candida albicans. Current Microbiology, 67, 322-326, 2013. 

47. Xuanrong Sun, Zhongchun Chen, Meihua Sui, Jianbin Tang and Youqing Shen. Parallel Synthesis of Polymers from Epoxy-Amine Reaction for Gene Delivery. 2012 Symposium on Innovative Polymers for Controlled Delivery. Journal of Controlled Release, 172, e118, 2012.

48. Jun Yang, Xuanrong Sun, Weiwei Mao, Meihua Sui, Jianbin Tang and Youqing Shen. Conjugate of Pt (IV)-Histone Deacetylase Inhibitor as Prodrug for Cancer Chemotherapy. Molecular pharmaceutics, 9(10), 2793-2800,2012.

49. Kedong Lu, Mingzhuo Cao, Weiwei Mao, Xuanrong Sun, Jianbin Tang, Youqing Shen and Meihua Sui. Targeted Acid-labile Conjugates of Norcantharidin for Cancer Chemotherapy. Journal of Materials Chemistry, 22, 15804-15811, 2012. 

50. Erlei Jin, Bo Zhang, Xuanrong Sun, Zhuxian Zhou, Xinpeng Ma,Qihang Sun, Jianbin Tang, Youqing Shen, Edward A Van Kirk,William J Murdoch, Maciej Radosz, Acid Active Cell-Penetrating Peptides for In Vivo Tumor-Targeted Drug Delivery.,Journal of the American Chemical Society, 135, 933-940, 2012. 

51. Hui Lu, ZhenYu Zhu, LingLing Dong, XinMing Jia, Xuanrong Sun, Lan Yan, YiFeng Chai, YuanYing Jiang, YingYing Cao. Lack of trehalose accelerates H₂O₂-induced Candida albicans apoptosis through regulating Ca2+ signaling pathway and caspase activity. Plos One, 6(1), e15808, 2011.

52. Shan Huang, Ying Ying Cao, Bao Di Dai, Xuanrong Sun, Zhen Yu Zhu, Yong Bing Cao, Yan Wang, Ping Hui Gao, Yuan Ying Jiang, In Vitro Synergism of Fluconazole and Baicalein against Clinical Isolates of Candida albicans Resistant to Fluconazole. Biological and Pharmaceutical Bulletin, 31(12), 2234-6, 2008.

授权专利：

1. 一种增强金黄霉素A水溶性的组合物及其制备与应用，专利号：202110326317.4

2. 一种抗癌药物组合物，证书号440551

2024年5月22日，课题组全体成员，毕业快乐。

2023.06 课题组全体成员（差一个高礼成，答辩完第二天骨折，提前毕业了。）

2023.05.17 恭喜2023届蔡悦博士顺利完成答辩！

2023.05.17 恭喜2023届程祥，高礼成，洪煜璐，邓淑芬，龚喻贝，李少广同学顺利完成答辩!

2022.05.16 2022届研究生毕业聚餐

2022.05.16 恭喜谢德晖，郑珊珊同学顺利完成答辩！