童胜强

药学院教授、博导，浙江省高校中青年学科带头人，省药学会药物分析专业委员会副主任委员、中国中西医结合学会中药专业委员会委员、浙江省药学会制药工程专业委员会委员，主要从事手性药物与中药药效物质等方面的研究。作为项目负责人获得包括国家自然科学基金、省科技厅重点研发、省自然科学基金等项目资助，第一或通讯作者在Trends in Analytical Chemistry, Analytical Chemistry, Food Bioscience, Analytica Chimica Acta, Journal of Ethnopharmacology, Journal of Chromatography A, Colloids and Surfaces A, Journal of Molecular Liquids等杂志发表学术论文150余篇，获授权发明专利17项。

讲授课程：

本科教学主要讲授《现代仪器分析》，《专业英语》

研究生教学主要讲授《药物结构解析与色谱学》，《药物分析进展》，《科技写作》，《中药分析学专论》

浙江工业大学第11届研究生“我心目中的好导师”

浙江工业大学校级优秀教师（先进工作者）

指导研究生3人次获省级优秀毕业论文

浙江省药学会科学技术奖二等奖

浙江工业大学教学质量优秀奖

主持项目(项目负责人)：

1.全二维液液色谱-液相色谱结合二维微馏分活性评价法筛选几种畲药植物中的降糖成分（LBY22H280004），浙江省自然科学基金（联合基金）

2.小金高原玫瑰高值化开发关键技术研究及应用（2025C04034），对口支援与科技合作，浙江省科技计划项目（重点研发-尖兵领雁）

3.动态限域空间环糊精框架构筑及在手性生物标志物分离中的应用研究（22478347），国家自然科学基金（面上项目）

4.亲脂性纳米硅胶粒健合手性试剂在高效离心分配色谱中的应用基础研究（21978266），国家自然科学基金（面上项目）

5.多重双相洗脱与双相识别模式在逆流色谱手性分离中的应用基础研究（21105090），国家自然科学基金（青年基金项目）

6.双相识别(S/M)逆流色谱分离手性药物的应用基础研究（Y4100472），浙江省自然科学基金（面上项目）

7.逆流色谱技术制备性分离药物对映体的工艺研究（2010C33144），浙江省科技厅（公益性项目）

8.金银花种植基地扩建与综合利用，浙江省科技厅（省科技特派员）

9.金银花种植基地建设与加工推广，浙江省科技厅（省科技特派员）

10.中药制剂药效物质基础与药理作用机制研究（KYY-HX-20240629）

11.玫瑰花系列产品开发（KYY-HX-20210732）

12.石楠藤和天麻素复合制剂开发（KYY-HX-20240467）

13.挥发油多维色谱分析方法开发（KYY-HX-20230917）

14.结肠透析方物质基础（KYY-HX-20230299）

15.人体血液中IS和P-CS含量测定方法开发（KYY-HX-20220357）

近三年科研论文：

30. Linna Xu,Weizhen Jiang,Huizhen Ni, Wentao Xu, Ankang Li, Jialong Wang, Junchao Zhu, Songlin Chen,Shengqiang Tong*.An efficient strategy for preparation of sulfobutylether-β-cyclodextrin chiral stationary phases for liquid chromatography. Journal of Chromatography A, 2025, 1757, 466133. https://doi.org/10.1016/j.chroma.2025.466133

29. Huizhen Ni, Wentao Xu, Linna Xu, Songlin Chen, Junchao Zhu, Shengqiang Tong*. Mercapto-β-Cyclodextrin Grafting Uniform Spherical Covalent Organic Frameworks for Enantioseparation in Liquid Chromatography. Analytica Chimica Acta, 2025, 1363, 344186. https://doi.org/10.1016/j.aca.2025.344186 

28. Junchao Zhu, Linna Xu, Wentao Xu, Huizhen Ni, Songlin Chen, Chu Chu, Dongping Cheng, Shengqiang Tong*. Multi-Interaction (Substituted-Phenylcarbamate)-Hydroxypropyl-β-Cyclodextrin Chiral Stationary Phases for Liquid Chromatography. Analytica Chimica Acta, 2025, 1358, 344104. https://doi.org/10.1016/j.aca.2025.344104

27. Chenlei Ma#, Honglei Bao#, Beibei Zhu, Junchao Zhu, Songlin Chen, Huawei Lv, Chu Chu, Shengqiang Tong*. Separation of Sesquiterpene Glycosides with α-Glucosidase Inhibitory Activity from Eriobotrya japonica (Thunb.) Leaves by High-Speed Countercurrent Chromatography. Journal of Chromatography A,  2025, 1746, 465780. https://doi.org/10.1016/j.chroma.2025.465780

26. Shandong Mao, Di Zhang, Shengqiang Tong*, Juan Jin*, Qiang He. Protective effect on pancreatic β cells of α-glucosidase inhibitors screened from Rehmannia glutinosa, Food Bioscience, 2023, 55, 103022.  

25. Haiping Xiang, Ping Xu, Weiyi Wen, Huiyun Qiu, Chu Chu*, Qingsong Shao*, Shengqiang Tong*. Screening, characterization of trace α-glucosidase inhibitors from the root of Pueraria lobata and evaluation of their hypoglycemic activity. Food Bioscience, 2023, 53: 102641. 

24. Huiyun Qiu, Beibei Zhu, Junchao Zhu, Songlin Chen, Chenlei Ma, Haiping Xiang, Shengqiang Tong*.Recent Advances in Application of Cyclodextrin-based Chiral Materials for Enantioseparation. Trends in Analytical Chemistry, 2024, 175: 117708. 

23. Songlin Chen, Junchao Zhu, Chenlei Ma, Beibei Zhu, Huiyun Qiu, Shengqiang Tong*. Mercapto-β-cyclodextrin Covalent Organic Frameworks for Enantioselective Liquid-Liquid Extraction. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2024, 687: 133496. 

22. Huiyun Qiu, Haiping Xiang, Mengyi Wen, Songlin Chen, Junchao Zhu, Shengqiang Tong*.Enantioseparation of two antifungal azole drugs by analytical countercurrent chromatography using sulfobutyl ether-β-cyclodextrin as chiral selector. Journal of Chromatography A, 2023, 1705, 464185. 

21. Junchao Zhu, Songlin Chen, BeiBei Zhu, Chenlei Ma, Huiyun Qiu, Lang Chen, Shengqiang Tong*. Enantiomeric analysis of γ(δ)-lactones by reversed-phase high-performance liquid chromatography using amylose tris(5-chloro-2-methylphenylcarbamate) as stationary phase. Journal of Chromatography A, 2024, 1720: 464779. 

20. Ben Chen, Songlin Chen, Mengyi Wen, Junchao Zhu, Shengqiang Tong*. Investigation of Three Sulfobutylether-ß-cyclodextrin Bonded Magnetic Nanoparticles in Enantioselective Liquid-Liquid Extraction, Journal of Molecular Liquids, 2023, 391(Part_B), 123362. 

19. Wenyu Sun, Huiyun Qiu, Haibo You, Ben Chen, Liqun Fang, Junqing Qian, Shengqiang Tong*. Degree and distribution of substitution of hydroxypropyl-β-cyclodextrin in enantioselective liquid-liquid extraction and countercurrent chromatographic enantioseparation. Journal of Chromatography A, 2023, 1687, 463684. 

18. Beibei Zhu, Huiyun Qiu, Chenlei Ma, Songlin Chen, Junchao Zhu, Shengqiang Tong*. Recent progress on chiral extractants for enantioselective liquid-liquid extraction. Journal of Chromatography A, 2023, 1709, 464389. 

17. Tingting Lin, Beibei Zhu, Mengyi Wen, Chenlei Ma, Shengqiang Tong*.Retention correlation and orthogonality between reversed phase countercurrent chromatography and liquid chromatography based on solvent strength. Journal of Chromatography A, 2023, 1707, 464322.  

16. Weiyi Wen, Haiping Xiang, Huiyun, Qiu, Jianwei Chen, Xuemin Ye*, Lin Wu, Zhiqiang Chen*, Shengqiang Tong*. Screening and identification of antibacterial components in Artemisia argyi essential oil by TLC – direct bioautography combined with comprehensive 2D GC×GC-TOFMS. Journal of Chromatography B, 2024, 124026. 

15. Ping Xu, Haiping Xiang, Weiyi Wen, Sihua Quan, Huiyun Qiu, Chu Chu, Shengqiang Tong*. Application of Two-Dimensional Reversed Phase Countercurrent Chromatography×High-Performance Liquid Chromatography to Bioactivity-guided Screening and Isolation of α-Glucosidase Inhibitors from Rheum palmatum L. Journal of Chromatography A, 2024, 464667. 

14. Haiping Xiang, Weiyi Wen, Ping Xu, Huiyun Qiu, Chu Chu, Qingsong Shao*, Shengqiang Tong*.Inhibition mechanism of α-glucosidase by three geranylated compounds: Kinetic, spectroscopic and molecular docking. Process Biochemistry, 2024, 136, 237-244. 

13. Wenyu Sun, Huiyun Qiu, Susu Lin, Shengqiang Tong*. Impact of the degree of substitution on the enantioseparation of anionic β-cyclodextrin in liquid‒liquid extraction and countercurrent chromatography: Insights from molecular docking simulations. Journal of Chromatography A 1733 (2024) 465255. 

12. Tao Ke, Zhongyuan Zhao, Junhuan Lin, Fengting Ou, Kaikai Chen, Kui Zeng, Debo He, Shengqiang Tong, Xinyi Wang, Lushan Yu*, Jing Chen. Development of a UHPLC-MS/MS method for the quantification of Pristinamycin IA and IIA in beagle dog plasma and its pharmacokinetic application. Journal of Pharmaceutical and Biomedical Analysis 251 (2024) 116401.

11. Weiyi Wen, Ping Xu, Haiping Xiang, Mengyi Wen, Xuemin Ye, Chu Chu*, Shengqiang Tong*. Comprehensive two-dimensional countercurrent chromatography × gas chromatography characterization of Artemisia argyi essential oil, Analytica Chimica Acta, 2023, 1237, 340614.

10. Ping Xu, Xiang Wang, Tingting Lin, Qingsong Shao, Jianyun Peng, Chu Chu, Shengqiang Tong*.A strategy for pinpointing natural bioactive components using 2D bioassay profilings combined with comprehensive 2D CCC×HPLC. Analytical Chemistry, 2022, 94(37): 12715-12722.

9.Xiaoyuan Lv, Haibo You,Huiyun Qiu, Mengyi Wen,Chuncui Zheng, Shengqiang Tong*. Separation of Acetylferrocene from synthetic mixtures by countercurrent chromatography. Journal of Liquid Chromatography & Related Technologies, 2022, 45(5-8), 94-99. https://doi.org/10.1080/10826076.2022.2143798 

8.Tingting Lin; Ben Chen; Liqun Fang; Haibo You; Chu Chu; Qingsong Shao; Shengqiang Tong*. Solvent strength of organic phase for two biphasic solvent systems in high speed countercurrent chromatography, Journal of Chromatography A, Available online 14 August 2022, 1680: 463422. https://doi.org/10.1016/j.chroma.2022.463422 

7.Heng-Mian Sun, Ai-Lian Zhang, Hong-Lei Bao, ChuChu*, Sheng-Qiang Tong*, In Silico Screening of Off-line Comprehensive Two-Dimensional Counter-current Chromatography with Liquid Chromatography for Four Saponins Isolation. Journal of Separation Science, 2022, 45(20), 3909-3918. http://doi.org/10.1002/jssc.202200395 

6.Ben Chen, Tingting Lin, Haibo You, Liqun Fang, Chu Chu, Jintao Yang*, Shengqiang Tong*. Preparation of Sulfobutylether-β-cyclodextrin Bonded Fe3O4/SiO2 Core-Shell Nanoparticles and its Application in Enantioselective Liquid-Liquid Extraction. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2022, 652: 129861. https://doi.org/10.1016/j.colsurfa.2022.129861

5.Haiping Xiang, Ping Xu, Huiyun Qiu, Weiyi Wen, Ailian Zhang, Shengqiang Tong*. Two-dimensional chromatography in screening of bioactive components from natural products, Phytochemical Analysis, 2022, 33(8), 1161-1176. https://doi.org/10.1002/pca.3168 

4.Wenyu Sun, Ben Chen, Haibo You, Liqun Fang, Junqing Qian*, Shengqiang Tong*. Enantioseparation of N-methyl duloxetine, duloxetine and fluoxetine by countercurrent chromatography using anionic β-cyclodextrin as chiral selector, Journal of Separation Science, First published: 22 May 2022, 45(15), 3022-3030. http://doi.org/10.1002/jssc.202200151 

3.Ben Chen, Haibo You, Liqun Fang, Tingting Lin, Ping Xu, Chu Chu, Shengqiang Tong*. Enantioseparation of five racemic N-alkyl drugs by reverse phase HPLC using sulfobutylether-β-cyclodextrin as a chiral mobile phase additive, Journal of Separation Science, First published: 24 March 2022,45(11),1847-1855. https://doi.org/10.1002/jssc.202200004 

2.Tingting Lin, Ping Xu, Ben Chen, Liqun Fang, Haibo You, Shengqiang Tong*, Solvent strength of aqueous phase for two typical biphasic solvent systems in high-speed countercurrent chromatography, Journal of Chromatography A, 2022, 1663, 462767. https://doi.org/10.1016/j.chroma.2021.462767 

1.Honglei Bao, Wenyu Sun, Hengmian Sun, Yang Jin, Xingchu Gong, Chu Chu, Shengqiang Tong*. Liquid chromatographic study of two structural isomeric pentacyclic triterpenes on reversed-phase stationary phase with hydroxypropyl-β-cyclodextrin as mobile phase additive，Journal of Pharmaceutical and Biomedical Analysis，Volume 207, 5 January 2022, 207, 114420. https://doi.org/10.1016/j.jpba.2021.114420 

授权专利（第一发明人）：

8. 一种功能化磁性纳米颗粒及作为手性萃取剂在液-液萃取拆分手性化合物中的应用，2025年7月1日，ZL 202310669774.2

7. 一种中药活性成分的二维筛选方法，2024年5月3日，中国，ZL 202210646838.2

6. 雷公藤药材及其制剂雷公藤多苷片中雷公藤内酯甲的测定方法, 2022年4月1日，中国，ZL201910937964.1

5. 一种枇杷叶中分离制备科罗索酸和山楂酸的方法，2021年12月21日，中国，ZL202011210351.7

4. 一种高速逆流色谱分离盐酸舍曲林顺反异构体的方法，2021年12月7日，中国，201910041453.1

3. 一种逆流色谱拆分反式帕罗醇的方法，2020年8月21日，中国，ZL201711043354.4

2. 一种莪术油中分离β-榄香烯的方法，2019年6月14日，中国， ZL201710216711.6

1. 一种布洛芬及酮基布洛芬对映异构体的拆分方法， 2019年1月8日，中国，ZL201611009772.7

科研获奖（第一获奖人）：

1. 双相识别、闭路循环与配位络合在逆流色谱手性分离中的应用及理论平衡模型，浙江省药学会科学技术奖，二等奖，2017.

2. 多样化洗脱逆流色谱制备性分离手性化合物，第二届浙江省自然科学学术奖，三等奖，2012.