吴澄帆

个人简介：

安徽阜阳人，博士，讲师。2015年毕业于吉林大学化学学院，2021年毕业于中国科学技术大学，获分析化学博士学位，导师梁高林教授（国家杰出青年科学基金获得者），同年6月被评为中国科学技术大学“校优秀毕业生”。2021年入职浙江工业大学生物工程学院。主要研究方向为自组装纳米药物与分子成像。近年来在Nat. Commun., Nano Lett., Adv. Healthcare Mater., ACS Nano等国际知名期刊上共发表SCI论文十余篇，其中第一作者论文6篇，第一通讯作者论文1篇。主持国家自然科学基金青年基金项目、浙江省自然科学基金探索公益项目、学校大型仪器设备开放基金各一项。

研究方向：

(1) 肿瘤靶向/微环境刺激响应型分子影像探针；

(2) 自组装纳米药物（水凝胶/核酸纳米药物）；

(3) 肿瘤微环境刺激响应型纳米药物。

一、代表性论文：

一作（含共一及通讯）：

1. 冯晶烨，黄文武，詹青怡，燕云峰，吴澄帆^*，瞬时纳米沉淀法制备壳聚糖/三聚磷酸钠纳米粒子及其siRNA递送性能评价，高分子通报，in press，2025. (中文B类)

2. Chengfan Wu, Pingge Jiang, Wen Su, Yunfeng Yan*. Alkaline Phosphatase-Instructed Peptide Assemblies for Imaging and Therapeutic Applications. Biomacromolecules 2024, 25, 5609-5629. (IF = 5.5, ZJUT TOP100)

3. Chengfan Wu, Wenjie Liao, Yujia Zhang, Yunfeng Yan*, Peptide-based supramolecular hydrogels and their biotherapeutic applications. Biomater. Sci., 2024, 12, 4855-4874. (IF = 5.8) 

4. Chengfan Wu, Chenchen Wang, Tong Zhang, Mengxing Wei, Yinglu Chen, Xiaoyan Li, Fuqiang Wang,* and Gaolin Liang*. Lysosome-Targeted and Fluorescence-Turned “On” Cytotoxicity Induced by Alkaline Phosphatase-Triggered Self-Assembly. Adv. Healthcare Mater. 2021, 2101346. (IF = 11.1)

5. Chengfan Wu,# Rui Zhang,# Wei Du, Liang Cheng,* and Gaolin Liang*. Alkaline Phosphatase-Triggered Self-Assembly of Near-Infrared Nanoparticles for the Enhanced Photoacoustic Imaging of Tumors. Nano Lett. 2018, 18 (12), 7749-7754. (IF = 10.8)

6. Chengfan Wu,# Zhen Zheng,# Yuenan Guo, Chongli Tian, Qiang Xue,* and Gaolin Liang*.  Fluorine Substitution Enhances The Self-Assembling Ability of Hydrogelators. Nanoscale 2017, 9, 11429-11433. (IF = 6.7)

7. Bin Wang,# Chengfan Wu,# Shufang He, Yaguang Wang, Di Wang, Hui Tao, Chenchen Wang, Xiaoxi Pang, Fei Li, Yue Yuan, Eric R. Gross, Gaolin Liang,* and Ye Zhang*. V1-Cal Hydrogelation Enhances Its Effects on Ventricular Remodeling Reduction and Cardiac Function Improvement post Myocardial Infarction, Chem. Eng. J., 2022, 433, 134450. (IF = 15.1)

8. Jinjing Li, Aichi Zhang, Andi Zhao, Zhaoxia Chen, Gaolin Liang,* Hu Liu,* and Chengfan Wu*. Weak Acid-Initiated Slow Release of Dexamethasone from Hydrogel to Treat Orbital Inflammation. Theranostics. 2023, 13 (12), 4030-4041. (IF = 12.4)

其他：

1. Yunfeng Yan*, Xiaomin Liu, Longyu Wang, Chengfan Wu, Qi Shuai, Yanmei Zhang, Shuai Liu. Branched Hydrophobic Tails in Lipid Nanoparticles Enhance mRNA Delivery for Cancer Immunotherapy. Biomaterials 2023, 301, 122279. (IF = 14.0) 

2. Yunfeng Yan*, Guangliang Zhang, Chengfan Wu, Qidi Ren, Xiaomin Liu, Fangqian Huang, Yi Cao and Wenbo Ye. Structural Exploration of Polycationic Nanoparticles for siRNA Delivery. ACS Biomater. Sci. Eng. 2022, 8 (5), 1964-1974. (IF = 5.8)

3. Chenchen Wang, Wei Du, Chengfan Wu, Shan Dan, Miao Sun, Tong Zhang, Bin Wang, Yue Yuan,* and Gaolin Liang*. Cathespin B-Initiated Cypate Nanoparticle Formation for Tumor Photoacoustic Imaging. Angew. Chem. Int. Ed. 2022, 61, e202114766. (IF = 16.6) 

4. Yinglu Chen, Chengfan Wu, Chenchen Wang, Tong Zhang, Yue Hua, Yang Shen,* and Gaolin Liang*. Bioluminescence Imaging of Urokinase-Type Plasminogen Activator Activity in Vitro and in Tumors. Anal. Chem. 2021, 93 (29), 9970-9973. (IF = 7.4)

5. Xiao Hu, Zijuan Hai, Chengfan Wu, Wenjun Zhan, and Gaolin Liang*. A Golgi-Targeting and Dual-Color “Turn-On” Probe for Spatially Precise Imaging of Furin. Anal. Chem. 2021, 93, 3, 1636-1642. (IF = 7.4)

6. Peiyao Chen,# Yinchu Ma,# Zhen Zheng,# Chengfan Wu, Yucai Wang,* and Gaolin Liang*. Facile Syntheses of Conjugated Polymers for Photothermal Tumour Therapy. Nat. Commun. 2019, 10, 1192. (IF = 16.6)

7. Jiali Tan,* Mei Zhang, Zijuan Hai, Chengfan Wu, Jiong Lin, Wen Kuang, Hang Tang, Yulei Huang, Xiaodan Chen, and Gaolin Liang*. Sustained Release of Two Bioactive Factors from Supramolecular Hydrogel Promotes Periodontal Bone Regeneration. ACS Nano 2019, 13 (5), 5616-5622. (IF = 17.1)

8. Wei Tang, Zhibin Zhao, Yuanyuan Chong, Chengfan Wu, Qingzhi Liu, Jingbo Yang, Rongbin Zhou, Zhe-Xiong Lian,* and Gaolin Liang*. Tandem Enzymatic Self-Assembly and Slow Release of Dexamethasone Enhances Its Antihepatic Fibrosis Effect. ACS Nano 2018, 12 (10), 9966-9973. (IF = 17.1)

9. Zhen Zheng, Gongyu Li, Chengfan Wu, Miaomiao Zhang, Yue Zhao, and Gaolin Liang*.  Intracellular Synthesis of D-aminoluciferin for Bioluminescence Generation. Chem. Commun. 2017, 53, 3567-3570. (IF = 6.1)

10. Zhen Zheng, Peiyao Chen, Maolin Xie, Chengfan Wu, Yufeng Luo, Wentao Wang, Jun Jiang and Gaolin Liang*. Cell Environment-Differentiated Self-Assembly of Nanofibers. J. Am. Chem. Soc. 2016, 138 (35), 11128-11131. (IF = 15.0)

二、代表性专著：

1. Chengfan Wu, Rui Zhang, Wei Du, Liang Cheng and Gaolin Liang*. Alkaline Phosphatase-Triggered Self-Assembly of Near-Infrared Nanoparticles for The Enhanced Photoacoustic Imaging of Tumors. Methods in Enzymology, 2021, Volume 657, ISSN 0076-6879. 

(1) 国家自然科学基金委，青年基金，22405240，酶响应模块化多肽纳米载体的构建及其高效诱导肝癌细胞铜死亡的研究，2025-01至2027-12，30万元，在研，主持。

(2) 浙江省自然科学基金委, 探索项目/探索公益/医疗健康，LTGY24B040001，智能粘附斑激酶响应型多肽水凝胶用于恶性乳腺癌诊疗一体化的研究，2024-01 至 2026-12，10万元，在研，主持。

(3) 2022年度学校大型仪器设备开放基金，含二硒键信使RNA脂质载体的构建和性能研究，2023-01-01至2026-12-31，3500元，在研，主持。

(4) 浙江工业大学人才引进科研启动金，2021-09-01至2024-12-30，5万元，结题，主持。

(5) 国家自然科学基金委员会, 面上项目, 22275167, 含二硒键信使RNA脂质载体的构建和性能研究, 2023-01-01 至 2026-12-31, 54万元, 在研, 参与。

(6) 国家自然科学基金委员会, 面上项目, 22175168, 间充质干细胞搭载可胞内自组装前体药物用于胶质瘤的靶向诊疗, 2022-01-01 至 2025-12-31, 60万元, 在研, 参与。

本科生课程《纳米生物技术》和研究生课程《生物技术前沿》。

(1) 2022，2023，2024本科生导师。

(2) 生物技术2301班本科班主任。