翁春跃

翁春跃，男，博士，副教授，硕士生导师。2015年6月于美国贝克曼研究中心获得生物科学专业博士学位。主要研究方向为利用深度学习辅助酶的理性设计，实现关键医药中间体的酶法合成；通过生物大数据分析解析微生物代谢产物高产机理，通过基因编辑技术完成微生物细胞工厂遗传改造，实现药用蛋白及工业酶制剂高效表达、代谢产物合成途径优化等。主持国家重点研发项目子课题1项、浙江省自然科学基金2项，参与国家自然科学基金等国家级项目、重大横向项目。发表SCI论文19篇，获批发明专利4项，参与编著专著3部。浙江生物信息学标委会委员，浙江工业大学第十四届青年教师教学竞赛十佳青年教师。

本科生：基因工程（全校教学示范课）、生物信息学

研究生：生物信息学（省优秀研究生课程）、科技论文写作、可再生资源生物加工与利用

主持并完成浙江工业大学校级教学改革项目1项，发表教学研究论文3篇：

1）1）翁春跃,王远山.基于OBE的翻转课堂教学模式在基因工程课程中的应用.高等生物学教学研究(电子版),2021,11(2): 16-20.

2）2）黄海婵,孙东昌,翁春跃.以OBE为导向的研究生《微生物学技术》课程教学改革与探索——以浙江工业大学为例.浙江工业大学学报(社会科学版),2019,18(3): 353-356.

3）3）程峰,熊能,翁春跃,李树芳,王亚军.新工科教育背景下“酶工程”课程教改的探索与实践.生物加工过程,2022,20(03):342-347.

浙江工业大学第十四届青年教师教学竞赛十佳青年教师，2020/2021学年校级优秀班主任，指导研究生获2021年度校级优秀硕士学位论文

1. 国家重点研发计划“合成生物学”重点专项子课题 (2020-2025, 45.7万元，在研，主持）

2. 浙江省自然科学基金探索项目（2022-2024，10万元，在研，主持）

3. 浙江省自然科学基金青年科学基金项目（2018-2020，8万元，结题，主持）

4. 国家自然科学基金面上项目(2019-2022，65万元，结题，参与）

代表性论文：

1)     Weng C, Li J, Chen Q, Han J, Dong Z, Liu Z, Zheng Y. UniESA: a unified data-driven framework for enzyme stereoselectivity and activity prediction. Green Chemistry, 2025, 27: 3777.

2)     Xu S, Chu R, Liu H, Weng C, Wang Y, Zheng Y. Computer-directed rational design enhanced the thermostability of carbonyl reductase LsCR for the synthesis of ticagrelor precursor. Biotechnology and Bioengineering, 2024, 121(5): 1532-1542.

3)     Liu H, Weng C, Zhou L, Xu H, Liao Z, Hong H, Ye Y, Li S, Wang Y, Zheng Y. Coevolving stability and activity of LsCR by a single point mutation and constructing neat substrate bioreaction system. Biotechnology and Bioengineering, 2023,120:1521.

4)     Cheng F, Zhou S, Chen L, Zhang W, Li S, Weng C, Wang Y, Zheng Y. Reaction-kinetic model-guided biocatalyst engineering for dual-enzyme catalyzed bioreaction system. Chemical Engineering Journal, 2022, 452:138997.

5)     Liu H, Weng C, Xu S, Li S, Wang Y, Zheng Y. Directed evolution of a carbonyl reductase LsCR for the enantioselective synthesis of (1S)-2-chloro-1-(3, 4-difluorophenyl) ethanol. Bioorganic Chemistry, 2022, 127:105991.

6)     Weng C, Gao X, Liu H, Chu R, Xie W, Wang Y, Zheng Y. Protein engineering of carbonyl reductases for asymmetric synthesis of ticagrelor precursor (1S)-2-chloro-1-(3, 4-difluorophenyl) ethanol. Biochemical Engineering Journal, 2022, 187:108600.

7)     Weng C, Mi Z, Li M, Qin H, Hu Z, Liu Z, Zheng Y, Wang Y. Improvement of S-adenosyl-L-methionine production in Saccharomyces cerevisiae by atmospheric and room temperature plasma-ultraviolet compound mutagenesis and droplet microfluidic adaptive evolution. 3 Biotech, 2022, 12(9):1-5. 

8)     王远山,戴科磊,谢卡茜,翁春跃.阿卡波糖及其结构类似杂质生物合成与调控的研究进展.生物工程学报,2022,38(02):605-619. 

9)     Weng C, Wang C, Xie W, Xu S, Wang Y, Zheng Y. Comparative proteome analysis of Actinoplanes utahensis grown on various saccharides based on 2D-DIGE and MALDI-TOF/TOF-MS. Journal of Proteomics, 2021, 239: 104193. 

10)  Weng C, Zhu M, Dai K, Mi Z, Wang Y, Liu Z, Zheng Y. Gene cascade shift and pathway enrichment in rat kidney induced by acarbose through comparative analysis. Frontiers in Bioengineering and Biotechnology, 2021, 9: 659700. 

11)  Weng C, Wang D, Ban S, Zhai Q, Hu X, Cheng F, Wang Y, Zheng Y. One-step eantioselective bioresolution for (S)-2-chlorophenylglycine methyl ester catalyzed by the immobilized Protease 6SD on multi-walled carbon nanotubes in a triphasic system. Journal of Biotechnology, 2021, 325: 294-302. 

12)  Cheng F, Chen Y, Qiu S, Zhai Q, Liu H, Li S, Weng C, Wang Y, Zheng. Controlling stereopreferences of carbonyl reductases for enantioselective synthesis of atorvastatin precursor. ACS Catalysis, 2021, 11(5): 2572-2582. 

13)  Weng C, Shi L, Wang Y, Zheng Y. Transcriptome analysis of Actinoplanes utahensis reveals molecular signature of saccharide impact on acarbose biosynthesis. 3 Biotech, 2020, 10(11): 1-9. 

14)  Weng C, Zhu M, Liu Z, Zheng Y. Integrated bioinformatics analyses identified SCL3-induced regulatory network in Arabidopsis thaliana roots. Biotechnology Letters, 2020, 42(6): 1019-1033. 

15)  Weng C, Hu X, Wang Y. Integrated analysis of gene expression, alteration and clinical significance of carcinoembryonic antigen-related cell adhesion molecule 1 in cancer. 3 Biotech, 2020, 10(3): 1-19. 

16)  Jin L, Xu Z, Zhang B, Yi M, Weng C, Lin S, Wu H, Qin X, Xu F, Teng Y, Yuan S, Liu Z, Zheng Y. Genome sequencing and analysis of fungus Hirsutella sinensis isolated from Ophiocordyceps sinensis. AMB Express, 2020, 10(1): 1-19. 

17)  Wang Y, Gong M, Wang X, Peng X, Wang Y, Guan J, Cheng D, Weng C, Zheng Y. Efficient degradation of ivermectin by newly isolated Aeromonas taiwanensis ZJB-18,044. Biodegradation, 2020, 31(4): 275-288.

18)  Cheng Y, Qiu S, Cheng F, Weng C, Wang Y, Zheng Y. Enhancing catalytic efficiency of an Actinoplanes utahensis echinocandin B deacylase through random mutagenesis and site-directed mutagenesis. Applied Biochemistry and Biotechnology, 2019:1-14.

19)  Weng C, Nguyen T, Shively J. miRNA-342 regulates CEACAM1-induced lumen formation in a 3D model of mammary gland morphogenesis.Journal of Biological Chemistry, 2016, 291(32): 16777-16786.

2022.04至今，浙江生物信息学标委会委员