魏斌

博士，副研究员，硕士生导师，主持国家重点研发计划青年科学家项目子课题、国家自然科学基金青年基金等科研项目9项，参与国家重点研发计划等其他横纵向项目6项。在天然药物与微生物组等领域已发表SCI论文90余篇(ESI高被引论文4篇)，其中以第一/通讯作者在Microbiome, Biotechnol. Adv., J. Med Chem., Bioresour. Technol., Environ. Microbiol., J. Nat. Prod.等国际权威期刊发表学术论文30余篇，已被Nature等高水平期刊引用1700余次。以第一发明人申请/授权发明专利或软件著作10余项。担任iMeta, Eur. J. Med. Chem.等20余种国际知名学术期刊审稿人和英国科学创新基金(UKRI)等项目通讯评审专家。

个人荣誉:

2022年度Front. Microbial. 期刊优秀审稿编辑

2023年入选浙江工业大学青年英才B类人才项目

2023年入选浙江工业大学高层次人才(C类优先资助)培育计划

学习经历:

2007.09-2011.06  武汉大学药学院  理学学士学位

2011.09-2013.06  武汉大学药学院  制药工程硕士学位

2013.09-2018.08  澳门大学中华医药研究院  生物医药博士学位

工作经历:

2018.11-至今  浙江工业大学药学院/绿色制药协同创新中心

研究方向:

1. 海洋微生物天然产化学

2. 微生物天然产物和代谢酶发现新策略

3. 天然产物与肠道菌相互作用研究

学术任职:

1. 中国药学会海洋药物专业委员会青年委员

2. 中国药理学会海洋药物药理专业委员会青年委员

3. iMeta, Chinese Medicine, Engineering Microbiology, Phytochemical Analysis等国际知名期刊青年编委

4. Front. Microbial. 期刊审稿编辑

5. Mar. Drugs, J. Mar. Sci. Eng.等期刊客座编辑

个人主页:

ResearchGate: https://www.researchgate.net/profile/Bin-Wei-7

GoogleScholar: https://scholar.google.com/citations?user=Taoas7gAAAAJ&hl=en

1. 国家自然科学基金国际(地区)合作项目《中埃红树林微生物菌群及抗菌次级代谢产物多样性研究》200万元  参与(排名第二)

2. 广西北部湾海洋资源环境与可持续发展重点实验室开放基金重点项目《北部湾红树林微生物次级代谢潜力研究》 3万元  主持

3. 国家重点研发计划青年科学家项目《基于原位富集培养和PSMPA策略的深海冷泉微生物药物先导化合物挖掘技术》子课题 60万元  主持

4. 浙江省属高校基本科研业务费项目《海洋微生物药物先导物的智能发现》10万元 主持

5. 国家自然科学基金面上基金项目《基于PSMPA技术的深海微生物抗细菌耐药性次级代谢产物多样性的研究》 56万元  参与(排名第二)

6. 国家自然科学基金青年基金项目《基于宏基因组技术的肠道菌多糖裂解酶介导海藻多糖治疗代谢综合征的研究》24万元  主持

7. 浙江省基础公益研究计划项目《肠道菌介导的黄嘌呤代谢对高脂饮食诱导的肥胖模型的影响》8万元  主持

8. 浙江省博士后择优资助项目《海带多糖与肠道菌多糖代谢酶的相互作用研究》5万元  主持

9. 自然资源部第二海洋研究所博士后项目《肠道菌多糖裂解酶介导海带多糖治疗肥胖的研究》7万元  主持

10. 企业横向项目《微生物转化在工业废液处理中的应用》10万元  主持

11. 企业横向项目《贵州笃山石斛口服液产品预研和质量研究》10万元  主持

代表性学术论文(^#第一作者, ^*通讯作者): 

38. Yi Hua^#, Gang-Ao Hu^#, Ti-Ti Ying, Jiang-Wei Pan, Zhen-Yi Zhou, Cui-Xian Zhang^*, Hong Wang^*, Bin Wei^*. The pathogenic fungal genus Corynespora: a prolific source of bioactive secondary metabolites. Journal of Natural Products (2025). (中科院二区, 药学TOP) Full text.pdf

37. Cai-Ling Yang^#, Pan-Pan Wang^#, Zhen-Yi Zhou, Xiao-Wen Wu, Yi Hua, Jian-Wei Chen, Hong Wang^*, Bin Wei^*. Discovery of naturally inspired antimicrobial peptides using deep learning. Bioorganic Chemistry (2025), 160: 108444. (中科院二区，有机化学小类一区)Full text.pdf

36. Buddha Bahadur Basnet, Zhen-Yi Zhou, Bin Wei^*, Hong Wang^*. Advances in AI-based strategies and tools to facilitate natural product and drug development. Critical Reviews in Biotechnology (2025). Full text.pdf (中科院二区, IF=8.2)

35. Ti-Ti Ying^#, Hao-Qiang Hu^#, Xiao-Wen Wu, Xu-Liang Xu, Jian Lv, Shu-Ning Zhang, Hong Wang, Wei Hou^*, Bin Wei^*, Guo-Wu Rao^*. Optimized ebselen derivatives as novel potent Escherichia coli β-glucuronidase covalent allosteric inhibitors. European Journal of Medicinal Chemistry (2025), 290: 117571. Full text.pdf (工大TOP100, IF=6.0) Highlighted by CBG资讯[Link]

34. Bin Wei^#,*, Ti-Ti Ying^#, Hua-Wei Lv^#, Zhen-Yi Zhou, Hai Cai, Gang-Ao Hu, Hui-Min Liang, Wen-Chao Yu, Yan-Lei Yu, Ai-Li Fan, Kui Hong, Xing-Nuo Li^*, Hong Wang^*. Global analysis of fungal biosynthetic gene clusters reveals the diversification of diketopiperazine biosynthesis. Bioresource Technology (2025), 422: 132218. Full text.pdf (中科院一区, 工大TOP100, IF=9.7) Highlighted by 遇见生物合成[Link]

33. Shu-Yu Yang^#(本科生), Ti-Ti Ying^#, Tian-Hui Zhou (本科生), Yu-Tian Guan, Xu-Liang Xu, Hong Wang^*, Bin Wei^*. The Myxobacterial Genus Archangium: A Prolific and Underexploited Source of Bioactive Secondary Metabolites. Journal of Medicinal Chemistry (2025), 68, 3: 2183-2197. Full text.pdf (中科院一区, 工大TOP100, IF=6.8) Highlighted by X-MOL[Link]; 浙工大药学院[Link]

32. Wei-Bing Chen^#, Gang-Ao Hu^#, Bing-Cheng Dong, Huai-Ying Sun, Dong-Ze Lu, Meng-Ying Ru, Yan-Lei Yu, Hong Wang^*, Bin Wei^*. Insights into the modulatory effects of host-gut microbial xanthine co-metabolism on high-fat diet-fed mice. Biochemical Pharmacology (2024), 230(1): 116596. Full text.pdf

31. Gang-Ao Hu^#, Yue Song^#,  Shi-Yi Liu, Wen-Chao Yu, Yan-Lei Yu, Hong Wang^*, Bin Wei^*. Exploring the diversity and specificity of secondary biosynthetic potential in Rhodococcus. Marine Drugs (2024), 22: 409. Full text.pdf

30. Si-Jia Wang^#, Zi-Xi Fu^#, Wei-Bing Chen, Si-Tong Wu, Song-Ze Ke, Jian-Feng Tu^*, Bin Wei^*. Saccharina japonica polysaccharides suppress high-fat diet-induced obesity and modulate gut microbiota composition and function. Chemistry & Biodiversity (2024), 21(8): e20241088. Full text.pdf

29. Man-Jing Ma^#, Wen-Chao Yu^#, Huai-Ying Sun, Bing-Cheng Dong, Gang-Ao Hu, Zhen-Yi Zhou, Yi Hua, Buddha Bahadur Basnet, Hong Wang^*, Bin Wei^*. Genus-specific secondary metabolome in Allokutzneria and Kibdelosporangium. Synthetic and Systems Biotechnology (2024), 9(3): 381-390. Full text.pdf Highlighted by 合成和系统生物技术[Link]

28. Bin Wei^#, Xian Luo^#, Zhen-Yi Zhou, Gang-Ao Hu, Lei Li^*, Hou-Wen Lin^*, Hong Wang^*. Discovering the secondary metabolic potential of Saccharothrix. Biotechnology Advances (2024), 70: 108295. Full text.pdf (中科院一区, IF=16.0) Highlighted by 遇见生物合成[Link]; 浙工大科研院[Link]

27. Qun-Jian Yin^#, Ti-Ti Ying^#, Zhen-Yi Zhou, Gang-Ao Hu, Cai-Ling Yang, Yi Hua, Hong Wang^*, Bin Wei^*. Species-specificity of the secondary biosynthetic potential in Bacillus. Frontiers in Microbiology (2023), 14: 1271418. Full text.pdf

26. Bin Wei^#, Gang-Ao Hu^#, Zhen-Yi Zhou, Wen-Chao Yu, Ao-Qi Du, Cai-Ling Yang, Yan-Lei Yu, Jian-Wei Chen, Hua-Wei Zhang, Qi-Hao Wu, Qi Xuan^*, Xue-Wei Xu^*, Hong Wang^*. Global analysis of the biosynthetic chemical space of marine prokaryotes. Microbiome (2023), 11: 144. Full text.pdf (中科院一区, IF=16.837) Highlighted by 遇见生物合成[Link]; 浙工大科研院[Link]

25. Bin Wei, Ao-Qi Du, Ti-Ti Ying (本科生), Gang-Ao Hu, Zhen-Yi Zhou, Wen-Chao Yu, Jing He, Yan-Lei Yu, Hong Wang^*, Xue-Wei Xu^*. Secondary metabolic potential of Kutzneria. Journal of Natural Products (2023), 86(4): 1120-1127. Full text.pdf (药学TOP, IF=4.803) Highlighted by 遇见生物合成[Link]; 相聚植化[Link]

24. Ying Song^#, Dong-Ze Lu^#, Hong-Gang Wang, Zhen-Yi Zhou, Xian Luo, Man-Jing Ma, Song-Ze Ke, Hong Wang, Yan-Lei Yu, Bin Wei^*. Metagenomic insights into the anti-obesity effect of a polysaccharide from Saccharina japonica. Foods (2023), 12(3): 665. Full text.pdf

23. Ao-Qi Du^#, Ti-Ti Ying^# (本科生), Zhen-Yi Zhou, Wen-Chao Yu, Gang-Ao Hu, Xian Luo, Man-Jing Ma, Yan-Lei Yu, Hong Wang^*, Bin Wei^*. Non-ribosomal peptide biosynthetic potential of the nematode symbiont Photorhabdus. Environmental Microbiology Reports (2022), 14: 917-925. Full text.pdf

22. Bin Wei^#, Bo Zhang^#, Ao-Qi Du, Zhen-Yi Zhou, Dong-Ze Lu, Zhong-Hui Zhu (本科生), Song-Ze Ke, Si-Jia Wang, Yan-Lei Yu, Jian-Wei Chen, Hua-Wei Zhang, Wei-Hua Jin^*, Hong Wang^*. Saccharina japonica fucan suppresses high fat diet-induced obesity and enriches fucoidan-degrading gut bacteria. Carbohydrate Polymers (2022), 290: 119411. Full text.pdf (中科院一区, IF=10.723) Highlighted by 热心肠日报[Link]

21. Song-Ze Ke^#, Bo Zhang^#, Yan-Lei Yu, Si-Jia Wang, Wei-Hua Jin, Jian Wu, Jian-Wei Chen, Hua-Wei Zhang, Bin Wei^*, Hong Wang^*. Structural characterization of a sulfated galactofucan from Undaria pinnatifida and its effect on type 2 diabetic mice. Journal of Oceanology and Limnology (2022), 41: 300-313. Full text.pdf

20. Bin Wei^#, Ao-Qi Du^#, Zhen-Yi Zhou, Cong Lai (本科生), Wen-Chao Yu, Jin-Biao Yu, Yan-Lei Yu, Jian-Wei Chen, Hua-Wei Zhang, Xue-Wei Xu^*, Hong Wang^*. An atlas of bacterial secondary metabolite biosynthesis gene clusters. Environmental Microbiology (2021), 23(11): 6981-6992. Full text.pdf (工大TOP100, IF=5.476) Highlighted by 遇见生物合成[Link]; 浙工大科研院[Link]

19. Bin Wei^#, Si-Jia Wang^#, Ya-Kun Wang, Song-Ze Ke, Wei-Hua Jin, Jian-Wei Chen, Hua-Wei Zhang, Jia-Dong Sun, Susanne M. Henning, Jian Wang^*, Hong Wang^*. Gut microbiota mediated-xanthine metabolism is associated with resistance to high-fat diet induced obesity. Journal of Nutritional Biochemistry (2021), 88: 108533. Full text.pdf

18. Qi-Wu Zhong, Tao-Shun Zhou, Wei-Hui Qiu, Ya-Kun Wang, Qiao-Li Xu, Song-Ze Ke, Si-Jia Wang, Wei-Hua Jin, Jian-Wei Chen, Hua-Wei Zhang, Bin Wei^*, Hong Wang^*. Characterization and hypoglycemic effects of sulfated polysaccharides derived from brown seaweed Undaria pinnatifida. Food Chemistry (2021), 341: 128148. Full text.pdf (中科院一区, IF=9.231) (ESI高被引论文)

17. Song-Ze Ke^#, Yan-Lei Yu^#, Qiao-Li Xu, Bo Zhang, Si-Jia Wang, Wei-Hua Jin, Bin Wei^*, Hong Wang^*. Composition-activity relationships of polysaccharides from Saccharina japonica in regulating gut microbiota in short-term high-fat diet-fed mice. Journal of Agricultural and Food Chemistry (2021), 69(37): 11121-11130. Full text.pdf (中科院一区, IF=5.895)

16. Bin Wei, Ya-Kun Wang, Shou-Kui Xiang, Yan Jiang, Rong Chen, Nan Hu^*. Alterations of gut microbiome in type 2 diabetes mellitus patients undergone cholecystectomy. American Journal of Physiology-Endocrinology and Metabolism (2021), 320(1): E113-E121. Full text.pdf

15. Bin Wei^#, Qiao-Li Xu^#, Bo Zhang, Tao-Shun Zhou, Song-Ze Ke, Si-Jia Wang, Bin Wu, Xue-Wei Xu^*, Wang Hong^*. Comparative study of Sargassum fusiforme polysaccharides in regulating cecal and fecal microbiota of high-fat diet-fed mice. Marine Drugs (2021), 19(7): 364. Full text.pdf

14. Bin Wei^#, Ya-Kun Wang^#, Jin-Biao Yu, Si-Jia Wang, Yan-Lei Yu, Xue-Wei Xu^*, Hong Wang^*. Discovery of novel glycoside hydrolases from C-glycoside-degrading bacteria using sequence similarity network analysis. Journal of Microbiology (2021), 59(10): 931-940. Full text.pdf

13. Tao-Shun Zhou^#, Lu-Lu He^#, Jing He (本科生), Zhi-Kun Yang, Zhen-Yi Zhou, Ao-Qi Du, Jin-Biao Yu, Ya-Sheng Li, Si-Jia Wang, Bin Wei^*, Zi-Ning Cui^*, Hong Wang^*. Discovery of a series of 5-phenyl-2-furan derivatives containing 1,3-thiazole moiety as potent Escherichia coli β-glucuronidase inhibitors. Bioorganic Chemistry (2021), 116: 105306. Full text.pdf

12. Ya-Sheng Li^#, Min He^#, Tao-Shun Zhou^#, Qin Wang^#, Lu-Lu He, Si-Jia Wang, Bei Hu, Bin Wei^*,  Hong Wang^*, Zi-Ning Cui^*. 2,5-Disubstituted furan derivatives containing 1,3,4-thiadiazole moiety as potent α-glucosidase and E. coli β-glucuronidase inhibitors. European Journal of Medicinal Chemistry (2021), 216: 113322. Full text.pdf (中科院一区, IF=7.088)

11. Xing-Nuo Li, Lu-Xia Hua, Tao-Shun Zhou, Ke-Bo Wang, Yuan-Yuan Wu, Mahmoud Emam, Xiao-Ze Bao, Jun Chen, Bin Wei^*. Cinnamic acid derivatives: inhibitory activity against Escherichia coli β-glucuronidase and structure-activity relationships. Journal of Enzyme Inhibition and Medicinal Chemistry (2020), 35.1: 1372-1378. Full text.pdf

10. Bin Wei, Qi-Wu Zhong, Song-Ze Ke, Tao-Shun Zhou, Qiao-Li Xu, Si-Jia Wang, Jian-Wei Chen, Hua-Wei Zhang, Wei-Hua Jin^*, Hong Wang^*. Sargassum fusiforme polysaccharides prevent high-fat diet-induced early fasting hypoglycemia and regulate gut microbiota composition. Marine Drugs (2020), 18(9): 444. Full text.pdf

9. Bin Wei^#, Ya-Kun Wang^#, Wen-Hui Qiu, Si-Jia Wang, Yue-Hong Wu, Xue-Wei Xu^*, Hong Wang^*. Discovery and mechanism of intestinal bacteria in enzymatic cleavage of C-C glycosidic bonds. Applied Microbiology and Biotechnology (2020), 104(5): 1883-1890. Full text.pdf

8. Xue Yang, Zhong-Hui Zhu (本科生), Xia Ji, Zhao-Ming Liu, Hua Zhang, Bin Wei^*. Complete genome sequence of Micromonospora craniellae LHW63014^T, a potential metal ion-chelating agent producer. Marine Genomics (2020), 57: 100830. Full text.pdf

7. Jian-Hua Yin^#, Wei Ren^#, Bin Wei^#, Hui-Min Huang, Ming-Xing Li, Xiao-Xiao Wu, An-Qi Wang et al. Characterization of chemical composition and prebiotic effect of a dietary medicinal plant Penthorum chinense Pursh. Food Chemistry (2020), 319: 126568. Full text.pdf (中科院一区, IF=9.231)

6. Song-Ze Ke^#, Bin Wei^#, Tao-Shun Zhou, Wen-Hui Qiu, Si-Jia Wang, Jun Chen, Jian-Wei Chen, Hua-Wei Zhang, Wei-Hua Jin, Hong Wang^*. Structural characterization and α-glucosidase inhibitory and antioxidant activities of fucoidans extracted from Saccharina japonica. Chemistry & Biodiversity (2020), 17.7: e2000233. Full text.pdf 

5. Tao-Shun Zhou^#, Bin Wei^#, Min He^#, Ya-Sheng Li, Ya-Kun Wang, Si-Jia Wang, Jian-Wei Chen, Hua-Wei Zhang, Zi-Ning Cui^*, Hong Wang^*. Thiazolidin-2-cyanamides derivatives as novel potent Escherichia coli β-glucuronidase inhibitors and their structure-inhibitory activity relationships. Journal of Enzyme Inhibition and Medicinal Chemistry (2020), 35(1): 1736-1742. Full text.pdf

4. Qi-Wu Zhong^#, Bin Wei^#, Si-Jia Wang, Song-Ze Ke, Jian-Wei Chen, Hua-Wei Zhang, and Hong Wang^*. The antioxidant activity of polysaccharides derived from marine organisms: an overview. Marine Drugs (2019), 17(12): 674. Full text.pdf (ESI高被引论文)

3. Bin Wei, Wei Yang, Zhi-Xiang Yan, Qing-Wen Zhang, Ru Yan^*. Prenylflavonoids sanggenon C and kuwanon G from mulberry (Morus alba L.) as potent broad-spectrum bacterial β-glucuronidase inhibitors: Biological evaluation and molecular docking studies. Journal of Functional Foods (2018), 48: 210-219. Full text.pdf

2. Bin Wei, Pan-Pan Wang, Zhi-Xiang Yan, Ru Yan^*. Characteristics and molecular determinants of a highly selective and efficient glycyrrhizin-hydrolyzing β-glucuronidase from Staphylococcus pasteuri 3I10. Applied Microbiology and Biotechnology (2018), 102(21): 9193-9205. Full text.pdf

1. Wei Yang^#, Bin Wei^#, Ru Yan^*. Amoxapine demonstrates incomplete inhibition of β-glucuronidase activity from human gut microbiota. SLAS Discovery: Advancing Life Sciences R&D (2018), 23(1): 76-83. Full text.pdf

参与发表的代表性学术论文:

2. Jian-Wei Chen^#,*, Wei Wang^#, Xu-Bin Hu, Yu-Jie Yue, Xing-Yue Lu, Chen-Jie Wang, Bin Wei, Hua-Wei Zhang, Hong Wang^*. Medium-sized peptides from microbial sources with potential for antibacterial drug development. Natural Product Reports (2024). [Full text]

1. Wang-Hui Jing^#, Si-Jing Dong^#, Xia-Lin Luo^#, Jing-Jing Liu, Bin Wei, Wei Du, Lin Yang, Hua Luo, Yi-Tao Wang, Si-Cen Wang^*, Hai-Tao Lu^*. Berberine improves colitis by triggering AhR activation by microbial tryptophan catabolites. Pharmacological Research (2021), 164: 105358. [Full text] (中科院一区, IF=10.334) (ESI高被引论文)

代表性发明专利/软件著作: 

3. 一种环烯醚萜苷类化合物在制备β-葡萄糖醛酸苷酶抑制剂中的应用, 魏斌等, 中国发明专利, ZL202010405502.8

2. 基于扩增子序列预测细菌次级代谢潜力的PSMPA软件, 魏斌等, 中国软件著作, 2022SR0269247

1. 扩增子与宏基因组组装基因组关联分析软件16S-MAG-linker, 魏斌等, 中国软件著作, 2024SR0105676

1. 主讲本科生专业课程《药物代谢动力学》

2. 主讲本科生专业课程《药品质量管理工程》

1. 2020年获浙江省互联网+创新创业大赛金奖1项，指导教师排名第四

2. 2021年获浙江省海洋知识创新竞赛一等奖1项，指导教师排名第二

3. 2022年度绿色制药协同创新中心优秀教师

4. 2023年指导本科生获第九届浙江工业大学“健行杯”本科生学术论坛三等奖1项，指导教师排名第一

5. 2023年被Frontiers in Microbiology评为"2022 Outstanding Review Editor"

6. 2023年指导研究生在第十四届全国微生物资源学术研讨会上获得“优秀墙报奖”，指导教师排名第一

7. 2023年指导研究生获国家奖学金

8. 2023年获第十六届海洋药物学术年会青年科学家论坛优秀报告奖

9. 2024年获浙江工业大学2023届本科生毕业设计优秀指导教师

10. 2024年获2023年浙江省专业学位研究生优秀实践成果指导教师