王芳

2019年1月博士毕业于北京大学生物医学工程系，2022年6月加入浙江工业大学药学院。近年主持在研国自然面上项目1项，国自然青年项目1项，省级项目3项，以第一作者或通讯作者在ACS Applied Materials & Interfaces, Nanoscale，Biomaterial Science等期刊发表SCI论文10余篇。

教学背景：

2009.09-2013.07  北京大学  生命科学学院  本科

2013.09-2019.01  北京大学  生物医学工程  博士  导师：罗莹教授

工作经历：

2019.02-2022.05  福建医科大学  药学院  副研究员

2022.06-至今    浙江工业大学  药学院  副研究员

研究方向：

纳米材料与生物体相互作用机制

智能仿生纳米靶向药物递送系统

核酸药物递送系统及其在疾病基因治疗中的应用

主讲本科生《药理学》

辅讲本科生《大学写作》主题实训部分

辅讲本科留学生《药学分子生物学》

辅讲研究生《细胞分子生物学》

主持纵向科研项目：

1. 国家自然科学基金面上项目，32471469，2025.01-2028.12，50万，在研，项目负责人。

2. 浙江省自然科学基金一般项目, LY24C140006，2024.01-2026.12,10万，在研，项目负责人。

3. 国家自然科学基金青年科学基金项目，31900994，2020.01-2022.12，24万，结题，项目负责人。

4. 福建省科技创新联合资金项目，2020Y9011，2021.08-2024.08，15万，结题，项目负责人。

5. 福建省自然科学基金面上项目，2020J01632，2020.11-2023.11，10万，结题，项目负责人。

主持横向科研项目：

1.维生素B2知识汇编及信息服务，浙江新维士，6万，2024.1-2025.3，在研。

主要参与科研项目：

福建省自然科学基金面上项目，2020J01621，2020.11-2023.11，10万，在研，排名3/9。

1. Ao Zhou, Jingyan Jia, Xueyang Ji, Sunying Cheng, Xiaoxin Song, Jingyan Hu, Yan Zhao, Luying Yu, Jieting Wang, Fang Wang*. Reshaped local and systemic immune responses triggered by a biomimetic multifunctional nanoplatform coordinating multi-pathways for cancer therapy [J]. ACS Applied Materials & Interfaces, 2024, 16(41): 55881-98.

2. Miaoliang Fan, Xiaoxin Song, Liwen Lu, Jiayan He, Yikai Shen, Changjun Zhang*, Fang Wang*, Yuanyuan Xie*. Comprehensive safety evaluation of a novel multitargeting compound XYY-CP1106: A candidate for Alzheimer's disease [J]. Biomedicine & Pharmacotherapy, 2024, 176: 116786.

3. Luying Yu#, Ao Zhou#, Jingyan Jia, Jieting Wang, Xueyang Ji, Yu Deng, Xinhua Lin*, Fang Wang*. Immunoactivity of a hybrid membrane biosurface on nanoparticles: enhancing interactions with dendritic cells to augment anti-tumor immune responses [J]. Biomaterials Science, 2024, 12(4): 1016-30.

4. Fang Wang^#, Yu Deng^#, Luying Yu^#, Ao Zhou, Jieting Wang, Jingyan Jia, Ning Li, Fadian Ding, Wei Lian, Qicai Liu, Yu Yang^*, Xinhua Lin^*. A macrophage membrane-polymer hybrid biomimetic nanoplatform for therapeutic delivery of somatostatin peptide to chronic pancreatitis. Pharmaceutics, 2022, 14(11):2341.

5. Fenglan Li^#, Yuanyuan Zhang^#, Fang Wang^#, Jinfa Chen, Bin Wang, Ning Li^*, Xinhua Lin^*, Junyang Zhuang^*. Metal–organic framework-based biomimetic cascade bioreactor for highly efficient treatment of hyperuricemia with low side effects. New Journal of Chemistry, 2022, 46(15): 6852-6855.

6. Fenglan Li^#, Tao Chen^#, Fang Wang^#, Jinfa Chen, Yuanyuan Zhang, Danting Song, Ning Li, Xin-Hua Lin^*, Lisen Lin^*, Junyang Zhuang^*. Enhanced cancer starvation therapy enabled by an autophagy inhibitors-encapsulated biomimetic ZIF-8 nanodrug: Disrupting and harnessing dual pro-survival autophagic responses. ACS Applied Materials & Interfaces, 2022, 14(19): 21860-21871.

7. Fang Wang, Wenda Hou, Chenglu Xiao, Yaoyao Hao, Ni Su, Yu Deng, Jieting Wang, Luying Yu, Jing-Ming Xie, Jing-Wei Xiong, Ying Luo^*. Endothelial cell membrane-based biosurface for targeted delivery to acute injury: Analysis of leukocyte-mediated nanoparticle transportation. Nanoscale, 2021, 13(35): 14636-14643.

8. Fang Wang^#,*, Yu Deng^#, Jieting Wang, Luying Yu, Fadian Ding, Wei Lian, Qicai Liu^*, Xinhua Lin^*. The PLGA nanoparticles for sustainable release of CGRP to ameliorate the inflammatory and vascular disorders in the lung of CGRP-deficient rats. Drug Delivery, 2021, 28(1): 865-872.

9. Jieting Wang^#, Luying Yu^#, Ao Zhou, Jie Liu, Kai Wang, Ying Luo^*, Fang Wang^*. Non-viral gene delivery systems for treatment of myocardial infarction: Targeting strategies and cardiac cell modulation. Pharmaceutics, 2021, 13(9):1520.

10. Ni Su, Yaoyao Hao, Fang Wang, Wenda Hou, Haifeng Chen, Ying Luo^*. Mesenchymal stromal exosome–functionalized scaffolds induce innate and adaptive immunomodulatory responses toward tissue repair. Science Advances, 2021, 7(20): eabf7207.

11. Fang Wang, Xi Wang, Lu Gao, Liu-Yi Meng, Jing-Ming Xie, Jing-Wei Xiong, Ying Luo^*. Nanoparticle-mediated delivery of siRNA into zebrafish heart: A cell-level investigation on the biodistribution and gene silencing effects. Nanoscale, 2019, 11(39): 18052-18064.

12. Chenglu Xiao, Fang Wang, Junjie Hou, XiaojunZhu, Ying Luo, Jing-Wei Xiong^*. Nanoparticle-mediated siRNA gene-silencing in adult zebrafish heart. JOVE, 2018, (137): e58054.

13. Fang Wang, Lu Gao, Liu-Yi Meng, Jing-Ming Xie, Jing-Wei Xiong, Ying Luo^*. A neutralized noncharged polyethylenimine-based system for efficient delivery of siRNA into heart without toxicity. ACS Applied Materials & Interfaces, 2016, 8(49): 33529-33538.2. 

14. Chenglu Xiao^#, Lu Gao^#, Yu Hou, Congfei Xu, Nannan Chang, Fang Wang, Keping Hu, Aibin He, Ying Luo, Jun Wang, Jinrong Peng, Fuchou Tang, Xiaojun Zhu^*, Jing-Wei Xiong^*. Chromatin-remodelling factor Brg1 regulates myocardial proliferation and regeneration in zebrafish. Nature Communications, 2016, 7(1): 13787.