薛斌

薛斌，博士，山西文水人，2020年毕业于天津科技大学，2020-2022在天津科技大学从事博士后研究，2023年入选浙江工业大学“青年英才”计划，2024年入选浙江工业大学“十四五高层次D类人才”培育计划。主要从事酶分子改造、生物催化与酶的高效表达。目前主持浙江省“尖兵”科技计划项目子课题1项，浙江省高校基本科研业务费项目1项，国家自然科学基金青年项目1项和中国博士后科学基金面上项目1项。在PNAS、eLife、J Cell Biol、ACS Synth Biol、Biotechnol Bioeng、Microb Cell Fact等知名期刊发表论文10篇，申请中国发明专利4项。

1. Yu-Qi Cheng, Xin-Ru Bian, Hui-Qi Mao, Chen Wang, Wen Zhang, Bin Xue*, Ya-Jun Wang. Oligomerization of fbaA Is Essential for Nonclassical Protein Export in Bacillus subtilis. ACS Synth Biol, 2026, DOI: 10.1021/acssynbio.5c00938.

2. Bin Xue, Bei-Feng-Chu Zheng, Hui-Qi Mao, Lu-Ying Gu, Xin-Ru Bian, Yuan Yuan, Muhammad Shafiq, Wen-Ting Dai, Ya-Jun Wang*. Structural and Functional Dissection of the Dimerization-Dependent Secretion Mechanism of BsPdhD in Bacillus subtilis. Biotechnol Bioeng, 2026, 123 (1): 64-78.

3. Bin Xue, Yang-Yang Li, Bei-Feng-Chu Zheng, Chan Zhang, Hadiatullah Hadiatullah, Wen-Ting Dai, Ya-Jun Wang, Zhen-Chuan Fan*. Expression and Characterization of Recombinant Triple Laterosporulin in Chlamydomonas reinhardtii. Probiotics Antimicro, 2026, 18: 278-288.

4. Yu-Long Zeng, Yang-Yang Li, Bei-Feng-Chu Zheng, Dong-Qi Xie, Sheng-Qiang Tong, Yuan Yuan, Ya-Jun Wang, Bin Xue*, Xiao-Guang Liu. Engineering Pichia pastoris for the efficient production of the high-value steroid intermediate 15α-OH-D-ethylgonendione. Microb Cell Fact, 2025, 24(1): 170.

5. Li-li Yao^#, Bin Xue^#, Yuan-Fan Ye, Zhi-Xiu Wang, Yang-Yang Li, Bei-Feng-Chu Zheng, Shu-Yun Ju, Ya-Jun Wang*. Structure-Guided Engineering of Carbonyl Reductase LbCR to Simultaneously Enhance Catalytic Activity and Thermostability toward Bulky Ketones. J Agric Food Chem, 2025, 73(17): 10470-10481.

6. Bin Xue^#,Yan-Xia Liu^#, Bin Dong, Jenna L. Wingfield, Mingfu Wu, Jun Sun, Karl F. Lechtreck, Zhen-Chuan Fan*. Intraflagellar transport protein RABL5/IFT22 recruits the BBSome to the basal body through the GTPase ARL6/BBS3. Proc Natl AcadSci U S A, 2020, 117(5): 2496-2505.

7. Wei-Yue Sun#, Bin Xue#, Yan-Xia Liu#, Rui-Kai Zhang , Rong-Chao Li, Wen Xin, Mingfu Wu, Zhen-ChuanFan*. Chlamydomonas LZTFL1 mediates phototaxis via controlling BBSome recruitment to the basal body and its reassembly at the ciliary tip. Proc Natl AcadSci U S A, 2021, 118(35): e2101590118.

8. Yan-Xia Liu^#, Bin Xue^#, Wei-Yue Sun, Jenna L Wingfield, Jun Sun, Mingfu Wu, Karl F Lechtreck, Zhelong Wu, Zhen-Chuan Fan*. Bardet-Biedl syndrome 3 protein promotes ciliary exit of the signaling protein phospholipase D via the BBSome. eLife, 2021, 10: e59119. 

9. Bin Xue^#, Chun-Ming Dong^#, He-He Hu, Bin Dong, Zhen-Chuan Fan*. Chlamydomonasreinhardtii-expressed Multimer of ToAMP4 Inhibits the Growth of Bacteria of both Gram-positive and Gram-negative. Process Biochem, 2020, 91: 311-318.

10. Yan-Xia Liu, Wei-Yue Sun, Bin Xue, Rui-Kai Zhang, Wen-Juan Li, XixianXie and Zhen-Chuan Fan*. ARL3 Mediates BBSomeCiliary Turnover by Promoting Its Outward Movement Across the Transition Zone. J Cell Biol, 2022, 221(10): e202111076.

11. Jin Dai, Gui Zhang, Rama A. Alkhofash, BetlehemMekonnen, SahanaSaravanan, Bin Xue, Zhen-Chuan Fan, EwelinaBetlina, Douglas G Cole, Peiwei Liu and Karl Lechtreck*. Loss of ARL13 impedes BBSome-dependent cargo export from Chlamydomonascilia. J Cell Biol, 2022, 221(10):e202201050.

1. 浙江省“尖兵”科技计划项目，2025C01121, 微生物细胞工厂的智能设计与工业应用, 2025/01-2026/12, 子课题负责人

2. 浙江省高校基本科研业务费项目，RF-A20240541, 工程化枯草芽孢杆菌底盘菌株生产蛋白质和高价值医药化学品, 2025-01-01-2027-12-31，项目负责人

3. 中国博士后科学基金,2021M692403, LZTFL1通过BBSome调控纤毛内号蛋白蛋白定位的研究，2021.01-2022.12, 8万元,  结题,  主持

4. 国家自然科学基金青年科学基金项目,32100541,LZTFL1调控BBSome 纤毛内运输的分子机制研究, 2022.01-2024.12, 30万元,  结题,  主持

本科生：《酶工程》；《分子生物学与基因工程》

研究生：《酶学与酶工程》

1. 王亚军，楚楚，孙彬，乔婧芳，苏为科，饶国武，杨志凯，薛斌，陆遥，沈寅初. 区域产业需求导向的绿色制药创新型人才培养模式改革10年实践探索.浙江工业大学2025年校级本科教学成果奖特等奖.

2. 薛斌，代文婷， 王亚军. 第七届全国药学专业学位优秀教学案例. 2024.

3.杨之凯，王亚军，居述云，薛斌，代文婷. 古道科技—类青石构型混凝土技术领跑者. 中国国际大学生创新大赛银奖. 2024.