徐鉴

课题组负责人介绍

徐鉴，教授，博士生导师，国家级青年人才项目获得者。2019年毕业于浙江大学化学系，获理学博士学位，2020年加入浙江工业大学生物工程学院。长期致力于酶催化的非天然反应构筑以及高效蛋白质工程改造策略的研究，主持国家优秀青年科学基金项目、国家自然科学基金面上项目、国家重点研发计划子课题等多项国家及省部级科研项目，在J. Am. Chem. Soc.、Nat. Commun.、Angew. Chem. Int. Ed.等国际权威期刊上发表论文20余篇。

团队介绍

课题组现有成员3人，其中教授1人（徐鉴）、副研究员1人（彭永珍）、讲师1人（段鑫宇），团队成员研究背景涵盖有机化学合成、生物催化等，实验室具有完备的合成、分析、表征仪器。团队注重学术交流与合作，积极组织成员参加国内外学术会议，拓宽学术视野，与国内外多所高校和科研机构建立了长期合作关系，定期邀请专家学者开展学术讲座与交流活动。课题组毕业生在科研、教学、企业等行业领域取得了优异成绩。

研究方向

本课题组主要围绕酶催化的非天然反应及蛋白质工程改造策略的开发和应用。在酶催化的非天然反应方面，模拟化学催化，利用光、电化学或其他化学手段调控辅因子，重塑酶催化机制，构筑多种酶催化的非天然反应。在蛋白质工程改造策略的研究方面，设计开发聚焦理性迭代特异性突变策略，用以酶的高效进化。相关研究成果在J. Am. Chem. Soc.、Nat. Commun.、Angew. Chem. Int. Ed.等高水平期刊上发表。此外，团队还积极开展蛋白质修饰的研究，结合前沿化学生物学技术，实现功能蛋白的改造与进化。课题组将继续深化现有研究方向，加强多学科交叉融合，积极拓展新的研究领域，不断提升团队的科研创新能力与学术影响力。

联系方式

地址：浙江工业大学莫干山校区生物工程学院A535、A537、B501、B503

Email：jianxu@zjut.edu.cn

招生信息

欢迎对生物催化感兴趣的本科生来组开展研究探索和毕业设计！

欢迎有意向攻读硕士、博士学位的同学提前联系我们！有意申请者请提供个人简历，发送至邮箱jianxu@zjut.edu.cn

课题组每年计划招收2-3名博士生（含硕博连读生）和若干名硕士生。

博士生：学术类 083600 生物工程（2-3名）

硕士生：学术类 083600 生物工程（多名）和071010 生物化学与分子生物学（少量名额）

专业类 086000 生物与医药（多名）

考研的同学请关注“浙江工业大学生物工程学院关于2026年硕士研究生招生考试自命题科目调整的说明”，详情参见学院相关网页介绍http://www.cbb.zjut.edu.cn/2025/0715/c9027a318314/page.htm

热忱欢迎有志于从事生物催化相关研究工作的同学加入我们课题组，也欢迎国内外同仁共同开展合作研究。

[24]  Dong Cui⁺, Xiaochen Cai⁺, Xinyu Duan⁺, Yuchen Chu, Bingyi Li, Zhiguo Wang*, Feng Cheng*, Jian Xu*, Metalloenzyme‐Catalyzed Asymmetric Transfer Hydrogenation for the Synthesis of Chiral Amines. Angew. Chem., Int. Ed. 2025, e202511298. DOI: 10.1002/anie.202511298.

[23]  Xinyu Duan⁺, Dong Cui⁺, Mengdi Wang⁺, Chenlu Jin, Xiaochen Cai, Zhiguo Wang*, Jian Xu*, Ground-State Flavin-Dependent Enzymes Catalyzed Enantioselective Radical Trifluoromethylation. Nat. Commun. 2025, 16, 1225. DOI:10.1038/s41467-025-56437-1.

[22] Shuang Liu, Runmiao Yang, Jian Xu*, Photoinduced Ene-Reductase Catalysis via Electron Donor–Acceptor Complexes. ChemBioChem 2025, 26, e202500329. DOI: 10.1002/cbic.202500329.

[21]  Linye Jiang+, Dannan Zheng⁺, Xiaoyang Chen⁺, Dong Cui, Xinyu Duan, Zhiguo Wang*, Jingyan Ge*, Jian Xu*, Photoenzymatic Redox-Neutral Radical Hydrosulfonylation Initiated by FMN. ACS Catal. 2024, 14, 6710-6716. DOI:10.1021/acscatal.4c00350.

[20] Weiqi Wang, Yuting Yu, Mengyao Wang, Yangxin Wang, Shanqiu Liu, Jian Xu*, Zhiyong Sun*, Pickering Emulsion Promoted Interfacial Sequential Chemo–Biocatalytic Reaction for the Synthesis of Chiral Alcohols from Styrene, ACS Appl. Mater. Interfaces 2024, 16, 40, 54799–54806. DOI: 10.1021/acsami.4c10461.

[19]  Xinyu Duan⁺, Dong Cui⁺, Mengdi Wang⁺, Yifan Tian⁺, Jianan Shi, Yixue Wu, Shuang Liu, Zejie Zhu,Jian Xu*, Deracemization of Sulfoxides Combining Electrocatalysis and Biocatalysis. Chin. J. Chem. 2024, 42, 3107-3112. DOI:10.1002/cjoc.202400567.

[18] Xiaoyang Chen⁺, Dannan Zheng⁺, Linye Jiang⁺, Zhiguo Wang, Xinyu Duan, Dong Cui, Shuang Liu, Yuan Zhang, Xiaomin Yu, Jingyan Ge, Jian Xu*, Photoenzymatic Hydrosulfonylation for the Stereoselective Synthesis of Chiral Sulfones. Angew. Chem., Int. Ed. 2023, 62, e202218140. DOI:10.1002/anie.202218140.

[17] Xinyu Duan⁺, Dong Cui⁺, Zhiguo Wang⁺, Dannan Zheng, Linye Jiang, Wenyu Huang, Yixia Jia*, Jian Xu*, A Photoenzymatic Strategy for Radical‐Mediated Stereoselective Hydroalkylation with Diazo Compounds. Angew. Chem., Int. Ed. 2023, 62, e202214135. DOI:10.1002/anie.202214135.

[16]  Weihua Xu, Kaihao Mou, Haonan Zhou, Jian Xu*, Qi Wu*, Transformation of Triolein to Biogasoline by Photo-Chemo-Biocatalysis. Green Chem. 2022, 24, 6589-6598. DOI:10.1039/D2GC01992B.

[15]  Yongzhen Peng, Zhiguo Wang, Yang Chen, Weihua Xu, Yujing Hu, Zhichun Chen, Jian Xu*, Qi Wu*, Photoinduced Promiscuity of Cyclohexanone Monooxygenase for the Enantioselective Synthesis of α‐Fluoroketones. Angew. Chem., Int. Ed. 2022, 61, e202211199. DOI:10.1002/anie.202211199.

[14]  Jian Xu⁺, Yujiao Lou⁺, Lanlan Wang⁺, Zhiguo Wang⁺, Weihua Xu, Wenqian Ma, Zhichun Chen, Xiaoyang Chen*, Qi Wu*, Rational Design of Biocatalytic Deuteration Platform of Aldehydes. ACS Catal. 2021, 11, 13348-13354. DOI:10.1021/acscatal.1c03659.

[13]  Jian Xu⁺, Jiajie Fan, Yujiao Lou, Weihua Xu, Zhiguo Wang, Danyang Li, Haonan Zhou, Xianfu Lin, Qi Wu*, Light-Driven Decarboxylative Deuteration Enabled by a Divergently Engineered Photodecarboxylase. Nat. Commun. 2021, 12, 3983. DOI:10.1038/s41467-021-24259-6.

[12]   Lanlan Wang, Yujiao Lou, Weihua Xu, Zhichun Chen, Jian Xu*, Qi Wu*, Biocatalytic Site-Selective Hydrogen Isotope Exchange of Unsaturated Fragments with D₂O. ACS Catal. 2021, 12, 783-788. DOI:10.1021/acscatal.1c05067.

[11]   Danyang Li, Tao Han, Jiadan Xue, Weihua Xu, Jian Xu*, Qi Wu*, Engineering Fatty Acid Photodecarboxylase to Enable Highly Selective Decarboxylation Of trans fatty Acids. Angew. Chem., Int. Ed. 2021, 60, 20695-20699. DOI:10.1002/anie.202107694.

[10]   Danyang Li, Xiaoyang Chen, Zhichun Chen, Xianfu Lin, Jian Xu*, Qi Wu*, Directed Evolution of Lipase a from Bacillus Subtilis for the Preparation of Enantiocomplementary Sec-Alcohols. Green Synth. Catal. 2021, 2, 290-294. DOI:10.1016/j.gresc.2021.07.003.

[9]    Xiaoyang Chen⁺*, Zhiguo Wang⁺, Yujiao Lou, Yongzhen Peng, Qiaoyan Zhu, Jian Xu*, Qi Wu*, Intramolecular Stereoselective Stetter Reaction Catalyzed by Benzaldehyde Lyase. Angew. Chem., Int. Ed. 2021, 60, 9326-9329. DOI:10.1002/anie.202100534.

[8] Yongzhen Peng, Danyang Li, Jiajie Fan, Weihua Xu, Jian Xu*, Huilei Yu, Xianfu Lin, Qi Wu*, Enantiocomplementary C–H Bond Hydroxylation Combining Photo‐Catalysis and Whole‐Cell Biocatalysis in a One‐Pot Cascade Process. Eur. J. Org. Chem. 2020, 2020, 821-825. DOI:10.1002/ejoc.201901682.

[7]   Jiajie Fan⁺, Yongzhen Peng⁺, Weihua Xu, Anlin Wang, Jian Xu*, Huilei Yu, Xianfu Lin, Qi Wu*, Double Enzyme-Catalyzed One-Pot Synthesis of Enantiocomplementary Vicinal Fluoro Alcohols. Org. Lett. 2020, 22, 5446-5450. DOI:10.1021/acs.orglett.0c01825.

[6]   Jian Xu⁺, Yongzhen Peng⁺, Zhiguo Wang, Yujing Hu, Jiajie Fan, He Zheng, Xianfu Lin, Qi Wu*, Exploiting Cofactor Versatility to Convert a FAD‐Dependent Baeyer–Villiger Monooxygenase into a Ketoreductase. Angew. Chem., Int. Ed. 2019, 58, 14499-14503. DOI:10.1002/anie.201907606.

[5]   Jian Xu⁺, Yixin Cen⁺, Warispreet Singh, Jiajie Fan⁺, Lian Wu⁺, Xianfu Lin, Jiahai Zhou, Meilan Huang*, Manfred T. Reetz*, Qi Wu*, Stereodivergent Protein Engineering of a Lipase to Access All Possible Stereoisomers of Chiral Esters with Two Stereocenters. J. Am. Chem. Soc. 2019, 141, 7934-7945. DOI:10.1021/jacs.9b02709.

[4]    Jian Xu⁺, Mamatjan Arkin, Yongzhen Peng, Weihua Xu, Huilei Yu, Xianfu Lin, Qi Wu*, Enantiocomplementary Decarboxylative Hydroxylation Combining Photocatalysis and Whole-Cell Biocatalysis in a One-Pot Cascade Process. Green Chem. 2019, 21, 1907-1911. DOI:10.1039/C9GC00098D.

[3]   Jian Xu, Yujing Hu, Jiajie Fan, Mamatjan Arkin, Danyang Li, Yongzhen Peng, Weihua Xu, Xianfu Lin, Qi Wu*, Light‐Driven Kinetic Resolution of α‐Functionalized Carboxylic Acids Enabled by an Engineered Fatty Acid Photodecarboxylase. Angew. Chem., Int. Ed. 2019, 58, 8474-8478. DOI:10.1002/anie.201903165.

[2]    Bo Xia⁺, Jian Xu⁺, Zhiwei Xiang⁺, Yixin Cen, Yujing Hu, Xianfu Lin, Qi Wu*, Stereoselectivity-Tailored, Metal-Free Hydrolytic Dynamic Kinetic Resolution of Morita–Baylis–Hillman Acetates Using an Engineered Lipase–Organic Base Cocatalyst. ACS Catal. 2017, 7, 4542-4549. DOI:10.1021/acscatal.7b01400.

[1]    Fan Xu⁺, Jian Xu⁺, Yujing Hu, Xianfu Lin, Qi Wu*, One-Pot Bienzymatic Cascade Combining Decarboxylative Aldol Reaction and Kinetic Resolution to Synthesize Chiral β-Hydroxy Ketone Derivatives. RSC Adv. 2016, 6, 76829-76837. DOI:10.1039/C6RA12729K.

2025年 所指导学生获得省级优秀毕业生2人（硕士研究生1人、本科生1人）

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2024.09 课题组教师节活动

2024.06 毕业生离校聚餐

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2022.09 课题组教师节活动