徐鉴

2014-2019  浙江大学化学系，博士，师从吴起教授； 

2019-2020 浙江大学 科研助理；

2020.7-至今 浙江工业大学，教授，国家级青年人才。

研究方向：酶催化多功能性，酶的定向进化，化学-酶级联催化等

Xinyu Duan, Dong Cui, Mengdi Wang, Chenlu Jin, Xiaochen Cai, Zhiguo Wang* & Jian Xu*, Ground-state flavin-dependent enzymes catalyzed enantioselective radical trifluoromethylation. Nat. Commun. 2025, 16, 1225.

Xinyu Duan, Dong Cui, Mengdi Wang, Yifan Tian, Jianan Shi, Yixue Wu, Shuang Liu, Zejie Zhu, Jian Xu*. Deracemization of Sulfoxides Combining Electrocatalysis and Biocatalysis. Chin. J. Chem. 2024, 42, 3107—3112.

Linye Jiang , Dannan Zheng  , Xiaoyang Chen , Dong Cui  , Xinyu Duan , Zhiguo Wang* , Jingyan Ge*  , Jian Xu* .Photoenzymatic Redox-Neutral Radical Hydrosulfonylation Initiated by FMN, ACS Catal. 2024.10.1021/acscatal.4c00350

X. Chen,+ D. Zheng,+ L. Jiang,+ Z. Wang, X. Duan, D. Cui, S. Liu, Y. Zhang, X. Yu, J. Ge and J Xu*,  Angew. Chem. Int. Ed. 2023, 10.1002/anie.202218140 

X. Duan†, D. Cui†, Z. Wang†, D. Zheng, L. Jiang, W. Huang, Y. Jia*, J. Xu*, Angew. Chem. Int. Ed. 2023, 10.1002/anie.202214135

 Y. Peng, Z. Wang, Y. Chen, W. Xu, Y. Hu, Z. Chen, J. Xu*, Q. Wu*, Photoinduced Promiscuity of Cyclohexanone Monooxygenase for the Enantioselective Synthesis of α-Fluoroketones, Angew. Chem. Int. Edit. 2022, 10.1002/anie.202211199.

W. Xu, K. Mou, H. Zhou, J. Xu*, Q. Wu*, Transformation of triolein to biogasoline by photo-chemo-biocatalysis, Green Chem. 2022, 24, 6589-6598.

L. Wang, Y. Lou, W. Xu, Z. Chen, J Xu*, and Q Wu*，Biocatalytic Site-Selective Hydrogen Isotope Exchange of Unsaturated Fragments with D2O，ACS Catal. 2022, 12,  733-761

J. Xu†*, Y. Lou†, L. Wang†, Z. Wang†, W. Xu, W Ma, Z. Chen, X. Chen*, and Q. Wu*, Rational Design of Biocatalytic Deuteration Platform of Aldehydes, ACS Catal. 2021, 11,  13348–13354

D. Li, T. Han, J. D. Xue, W. H. Xu, J. Xu*, Q. Wu*, Engineering Fatty Acid Photodecarboxylase To Enable the Highly selective Decarboxylation of trans Fatty Acids, Angew. Chem. Int. Edit. 2021, 60, , 20695-20699.

J. Xu†*, J. J. Fan†, Y. J. Lou†, W. H. Xu†, Z. G. Wang†, D. Y. Li, H. N. Zhou, X. F. Lin, Q. Wu, Light-driven decarboxylative deuteration enabled by a divergently engineered photodecarboxylase, Nat. Commun. 2021, 12,  3983.

D. Li, X. Chen, Z. Chen, X. Lin, J. Xu*, Q. Wu*, Directed Evolution of Lipase A from Bacillus Subtilis for the Preparation of Enantiocomplementary Sec-alcohols, Green. Synth. Catal. 2021, https://doi.org/10.1016/j.gresc.2021.07.003. 

X. Y. Chen†*, Z. G. Wang†, Y. J. Lou, Y. Z. Peng, Q. Y. Zhu, J. Xu*, Q, Wu*, Intramolecular Stereoselective Stetter Reaction Catalyzed by Benzaldehyde Lyase, Angew. Chem. Int. Edit. 2021, 60, 9326-9329.

J. Xu†, Y.X. Cen†, W. Singh, J. Fan, L. Wu, X.F. Lin, J.H. Zhou*, M. Huang*, M. T. Reetz*, & Q. Wu*, Stereodivergent Protein Engineering of a Lipase to Access All Possible Stereoisomers of Chiral Esters with Two Stereo-centers, J. Am. Chem. Soc. 2019, 141, 7934-7945.

J. Xu, Y. Hu, J. Fan, M. Arkin, D. Li, Y. Peng, W. Xu, X. Lin & Q. Wu*, Light-Driven Kinetic Resolution of α-Functionalized Carboxylic Acids Enabled by Engineered Fatty Acid Photodecarboxylase, Angew. Chem. Int. Edit. 2019, 58, 8474-8478.

J Xu†, Y.Z Peng†, Z.G Wang, Y.J Hu, J.J Fan, H Zheng, X.F Lin, Q Wu*, Exploiting Cofactor Versatility to Convert a FAD Dependent Baeyer−Villiger Monooxygenase into a Ketoreductase, Angew. Chem. Int. Edit. 2019, 59, 14499-14503.

J. Xu, M. Arkin, Y. Z Peng, W. H Xu, H. L. Yu, X. F. Lin and Q. Wu*, Enantiocomplementary Decarboxylative Hydroxylation Combining Photocatalysis and Whole-Cell Biocatalysis in a One-pot Cascade Process, Green. Chem. 2019, 21, 1907-1911.

B Xia†, J. Xu†, Z. W. Xiang†, Y. X. Cen, Y. J. Hu, X. F. Lin, Q. Wu*, Stereoselectivity-Tailored, Metal-Free Hydrolytic Dynamic Kinetic Resolution of Morita-Baylis-Hillman Acetates Using an Engineered Lipase-Organic Base Cocatalyst. ACS Catal. 2017, 7, 4542-4549. 

Enantiocomplementary C–H Bond Hydroxylation Combining Photo-Catalysis and Whole-Cell Biocatalysis in a One-Pot Cascade Process. Y.Z Peng, D.Y Li, J.J Fan, W. H Xu, J Xu*,H .L Yu, X.F Li, and Q Wu*. Eur. J. Org. Chem. 2020, 821–825. 

J. J Fan, Y.Z Peng, W. H Xu, A. L Wang, J. Xu*, H. L Yu, X. F Lin and Q. Wu*, Double Enzyme-catalyzed One-Pot Synthesis of Enantiocomplementary Vicinal Fluoro Alcohols. Org. Lett. 2020, 22, 14, 5446–5450. 

F. Xu†, J. Xu†, Y. J. Hu, X. F. Lin, Q. Wu, One-pot bienzymatic cascade combining decarboxylative aldol reaction and kinetic resolution to synthesize chiral beta-hydroxy ketone derivatives. RSC Adv. 2016, 6, 76829-76837.