燕云峰

 燕云峰，博士。1998.9-2002.6，安徽师范大学化学系本科；2002.7-2007.6，中国科学技术大学化学物理系博士（导师：张广照教授）；2007.7-2009.9，复旦大学高分子系博士后（导师：江明院士、姚萍教授）；2009.10-2011.2，上海师范大学化学系讲师；2011.3-2012.7，美国麻省大学（University of Massachusetts, Amherst）化学系postdoc（合作导师：Prof. Paul Dubin）；2012.8-2017.1，美国德克萨斯大学西南医学中心（University of Texas Southwestern Medical Center）Postdoc, Research Scientist（合作导师：Prof. Daniel Siegwart）。2017.3-至今，浙江工业大学生物工程学院工作。主要研究方向是生物材料与纳米生物药物，包括针对RNA核酸药物（siRNA, miRNA, mRNA等）和CRISPR基因编辑体系的新型高分子和脂质载体的研究开发及其在癌症治疗、组织工程和免疫调控等方面应用。

主持浙江省和国家自然科学基金多项，目前担任中国感光学会生物基功能大分子材料与技术专业委员会委员、中国毒理学会青年委员会委员、浙江省毒理学会毒理学替代法专业委员会委员。长期担任Nat. Commun., J. Mater. Chem. B, Chem. Commun., Acs Appl. Mater. Inter. Sci., Acta Biomater.等主流期刊审稿人。

办公室：莫干山校区生工楼A523。

联系方式：0571-88813129; yfyan@zjut.edu.cn

主讲/共同主讲本科生《细胞生物学》、《纳米生物学》、《专业英语》和研究生《科技论文写作》等课程。

研究方向：生物材料与纳米生物药物

      聚焦生命健康前沿领域，针对新型生物药物（如核酸、多肽、蛋白质）和新兴生物技术（如RNA干扰和CRISPR基因编辑）在生物医学应用中的问题，结合材料化学和纳米技术等多学科手段，从分子、纳米、细胞和组织多尺度调控药物和生物分子的作用，提高生物药物的稳定性、靶向性和治疗效果，促进新兴生物技术在生物医学中的应用。

承担项目：

1、浙江省自然科学基金/重点项目，功能化纳米脂质体的构建及其膜融合介导的mRNA递送研究，2025.1-2027.12

2、国家自然科学基金/面上项目，含二硒键信使RNA脂质载体的构建和性能研究，2023.1-2026.12

3、国家自然科学基金/联合基金，高分子-siRNA纳米粒子的内部结构及其对siRNA递送的影响，2020.1-2022.12

4、浙江省自然科学基金/一般项目，PAGE-b-PEO-b-PCL功能化嵌段共聚物的制备及其在信使 RNA递送中的应用，2019.1-2021.12

5、横向项目，类脂质体的合成技术开发，2021.6-2023.12

6、聚合物分子工程国家重点实验室开放课题基金。2017-2019

在PNAS, Biomaterials等著名期刊发表论文五十余篇，获授权中国发明专利四件。

2025年

1. Yuduo Gao, Luwei Zhang, Ziyue Wang, Hao Bai, Chengfan Wu, Qi Shuai, and Yunfeng Yan* Enhanced Pulmonary and Splenic mRNA Delivery Using DOTAP-Incorporated Poly(beta-Amino Ester)-Lipid Nanoparticles. Biomacromolecules 2025, 26(1), 623-634 (IF: 5.5/Q1, ZJUT Top100, Biology and Biochemistry ESI)

2. 刘怀艺（21级本科生），黄方茜，陈柏求，燕云峰* “壳聚糖/透明质酸复合物纳米粒子的制备及其在siRNA递送中的应用” 生物工程学报，2025, 41(4), 1340-1353

3. Longyu Wang, Yichen Li, Pingge Jiang, Hao Bai, Chengfan Wu, Qi Shuai, and Yunfeng Yan* Enhanced mRNA Delivery via Incorporating Hydrophobic Amines into Lipid Nanoparticles. Colloids and Surfaces B: Biointerfaces 2025, 249, 114528 (IF: 5.4/Q1, Biology and Biochemistry ESI)

4. 冯晶烨（21级本科生），黄文武，詹青怡，燕云峰，吴澄帆* “瞬时纳米沉淀法制备壳聚糖/三聚磷酸钠纳米粒子及其siRNA递送性能评价” 高分子通报，2025, 38(3), 460-471

5. Sunqi Yu, Siyuan Chen, Tianrui Tong, Yunfeng Yan, Qi Shuai* pH and ROS Dual-Responsive Core-Cross-Linked Micelles Based on Boronic Ester Linkage for Efficient PTX Delivery. Journal of Polymer Science 2025, 63(6), 1319-1333

2024年

1. Chengfan Wu, Pingge Jiang, Wen Su, and Yunfeng Yan* Alkaline Phosphatase-Instructed Peptide Assemblies for Imaging and Therapeutic Applications. Biomacromolecules 2024, 25(9), 5609–5629 (IF: 5.5/Q1, ZJUT Top100, Biology and Biochemistry ESI)

2. Chengfan Wu, Wenjie Liao, Yujia Zhang, and Yunfeng Yan* Peptide-based supramolecular hydrogels and their biotherapeutic applications. Biomaterials Science 2024, 12, 4855-4874 (IF: 5.8/Q1)

3. Baiqiu Chen, Qidi Ren, Pingge Jiang, Qiong Wu, Qi Shuai, and Yunfeng Yan* Combinatorial Synthesis of Alkyl Chain-Capped Poly(β-Amino Ester)s for Effective siRNA Delivery. Macromolecular Bioscience 2024, 24 (10), 2400168 (IF: 4.4/Q1, Biology and Biochemistry ESI)

4. Qi Shuai, Wanxuan Xie, Siyuan Chen, Huahui Su and Yunfeng Yan* Novel aromatic moieties-modified poly(glycidyl amine)s with potent siRNA delivery and cancer treatment effect. Journal of Materials Chemistry B 2024, 12, 3115 (IF: 6.1/Q1, ZJUT Top100)

5. Wenfei Qian, Hao Bai, Yunfeng Yan*, and Qing Bi Regulation of Physicochemical Properties of Alginate-based Hydrogels and Preliminary Applications in Wound Healing. International Journal of Biological Macromolecules 2024, 283, 137627 (IF: 7.7/Q1, Biology and Biochemistry ESI)

2023年

1. Yunfeng Yan,* Xiaomin Liu, Longyu Wang, Chengfan Wu, Qi Shuai, Yanmei Zhang, and Shuai Liu Branched Hydrophobic Tails in Lipid Nanoparticles Enhance mRNA Delivery for Cancer Immunotherapy. Biomaterials 2023, 301, 122279 (IF: 12.8/Q1)

2. Qidi Ren, Lu Wang, Wenfei Qian, Baiqiu Chen, Qi Shuai,* and Yunfeng Yan* Flash Nanoprecipitation Fabrication of PEI@Amorphous Calcium Carbonate Hybrid Nanoparticles for siRNA Delivery. Macromolecular Bioscience 2023, 23, 2300085 (IF: 4.4/Q1, Biology and Biochemistry ESI)

2022年

1. Wenbo Ye, Fangtao Zhu, Yue Cai, Longyu Wang, Guangliang Zhang, Guangkuo Zhao, Xiaohe Chu, Qi Shuai, Yunfeng Yan* Improved paclitaxel delivery with PEG-b-PLA/zein nanoparticles prepared via flash nanoprecipitation. International Journal of Biological Macromolecules 2022, 221, 486-495 (IF: 7.7/Q1, Biology and Biochemistry ESI)

2. Yunfeng Yan, Fangtao Zhu, Huahui Su, Xiaomin Liu, Qidi Ren, Fangqian Huang, Wenbo Ye, Mengdan Zhao, Yunchun Zhao, Junpeng Zhao*, and Qi Shuai* Construction of Degradable and Amphiphilic Triblock Polymer Carriers for Effective Delivery of siRNA. Macromolecular Bioscience 2022, 22(12), 2200232 (IF: 4.4/Q1, Biology and Biochemistry ESI)

3. Fengfan Liu, Huahui Su, Mengqian Li, Wanxuan Xie, Yunfeng Yan,* Qi Shuai* Zwitterionic Modification of Polyethyleneimine for Efficient In Vitro siRNA Delivery. International Journal of Molecular Sciences 2022, 23, 5014 (IF: 4.9/Q1)

4. Yunfeng Yan,* Guangliang Zhang, Chengfan Wu, Qidi Ren, Xiaomin Liu, Fangqian Huang, Yi Cao, and Wenbo Ye Structural Exploration of Polycationic Nanoparticles for siRNA Delivery. ACS Biomaterials Science & Engineering 2022, 8, 1964−1974 (IF: 5.4/Q2)

5. Wen Zhang, Wenbo Ye, Yajun Wang, Yunfeng Yan* Microfluidic fabrication of tunable alginate-based microfibers for the stable immobilization of enzymes. Biotechnology Journal 2022, 17, 2200098 (IF: 3.2/Q1, Biology and Biochemistry ESI)

6. Wenbo Ye, Guangliang Zhang, Xiaomin Liu, Qidi Ren, Fangqian Huang, Yunfeng Yan* Fabrication of polysaccharide-stabilized zein nanoparticles by flash nanoprecipitation for doxorubicin sustained release. Journal of Drug Delivery Science and Technology 2022, 70, 103183 (IF: 4.5/Q1)

7. Wen Zhang, Wenbo Ye, Yunfeng Yan* Advances in Photo‐Crosslinkable Materials for 3D Bioprinting. Advanced Engineering Materials 2022, 24, 202100663 (IF: 3.4/Q2) 

2021年

1. Lu Wang, Yunfeng Yan* A Review of pH-Responsive Organic-Inorganic Hybrid Nanoparticles for RNAi-Based Therapeutics. Macromolecular bioscience 2021, 21, e2100183 (IF: 4.4/Q1, Biology and Biochemistry ESI)

2. Qi Shuai, Fangtao Zhu, Mengdan Zhao, YunfengYan* mRNA delivery via non-viral carriers for biomedical applications. International Journal of Pharmaceutics 2021, 607, 121020 (IF: 5.3/Q1, ZJUT Top100)

3. Guangkuo Zhao, Tongtong Ge, Yunfeng Yan, Qi Shuai*, Weike Su Highly Efficient Modular Construction of Functional Drug Delivery Platform Based on Amphiphilic Biodegradable Polymers via Click Chemistry. International Journal of Molecular Sciences 2021, 22, 10407 (IF: 4.9/Q1)

4. Xianjing Jia, Yunfeng Yan, A Basak Kayitmazer, Yongsheng Li*, Yisheng Xu* Scalable Yielding of Highly Stable Polyelectrolyte‐Coated Copper Sulfide Nanoparticles by Flash Nanoprecipitation for Photothermal‐Chemotherapeutics. Advanced Functional Materials 2021, 31, 2100452 (IF: 18.5/Q1)

5. Chengyuan Xu, Yang Chen, Yi Si*, Yunfeng Yan, Basak Kayitmazer, Yong Ding, Weiwei Qian, Zhiyuan Zheng, Song Cao, Yisheng Xu* Injectable and Biocompatible Mussel‐Inspired Adhesive for Enhanced Reendothelialization of Injured Artery. Advanced Materials Interfaces 2021, 8 (7), 2001955 (IF: 4.3/Q2)

6. Yi Hou*, Xiaolin Wei*, Yunfeng Yan*, Jing Hao* Target-Triggered Nanoparticles for Tumor Diagnosis and Therapy. Frontiers in Chemistry 2021, 9, 657782 (IF: 3.8/Q2)

7. Lian Xue, Yunfeng Yan, * Petra Kos, Xiaoping Chen, Daniel J. Siegwart* PEI fluorination reduces toxicity and promotes liver-targeted siRNA delivery. Drug Delivery and Translational Research 2021, 11, 255–260 (IF: 5.7/Q1)

2020年

1. Kejin Zhou, Lindsay T. Johnson, Hu Xiong, Sergio Barrios, Jonathan T. Minnig, Yunfeng Yan, Bethanie Abram, Xueliang Yu, and Daniel J. Siegwart* Hydrophobic Domain Structure of Linear-Dendritic Poly(ethylene glycol) Lipids Affects RNA Delivery of Lipid Nanoparticles. Molecular Pharmaceutics 2020, 17, 1575-1585 (IF: 4.5/Q1)

2. Yunfeng Yan* and Hangwei Ding pH-Responsive Nanoparticles for Cancer Immunotherapy: A Brief Review. Nanomaterials2020, 10, 1613 (IF: 4.4/Q1)

2019年

1. Xiaohan Wang, Xiaotao Zhao, Kai Zheng, Xuhong Guo, Yunfeng Yan,* and Yisheng Xu* Ratiometric nanoparticle array-based near infrared fluorescent probes for quantitative protein sensing. Langmuir 2019, 15, 5599-5607 (IF: 3.7/Q2)

2. Chengyuan Xu^#, Yunfeng Yan^#, Jinchao Tan, Dahai Yang, Xianjing Jia, Lu Wang, Yisheng Xu,* Song Cao,* and Shengtong Sun* Biodegradable Nanoparticles of Polyacrylic Acid Stabilized Amorphous CaCO3 for Tunable pH-Responsive Drug Delivery and Enhanced Tumor Inhibition. Advanced Functional Materials 2019, 29, 1801846 (co-first author, IF: 18.5/Q1)

2018年

1. Hu Xiong, Kejin Zhou, Yunfeng Yan, Jason B. Miller, and Daniel J. Siegwart* Tumor activated water-soluble photosensitizers for near-infrared photodynamic cancer therapy. Acs Applied Materials & Interfaces 2018, 10, 16335–16343 (IF: 8.3/Q1)

2. Meng Li, Yisheng Xu*, Jinli Sun, Mingwei Wang, Dahai Yang, Xuhong Guo, Haiyun Song, Song Cao*, and Yunfeng Yan* Fabrication of Charge-Conversion Nanoparticles for Cancer Imaging by Flash Nanoprecipitation. Acs Applied Materials & Interfaces 2018, 10, 10752-10760 (IF: 8.3/Q1)

2017年

1. Yunfeng Yan*, Hu Xiong, Xinyi Zhang, Qiang Chen, and Daniel J. Siegwart* Systemic mRNA Delivery to the Lungs by Functional Polyester-based Carriers. Biomacromolecules 2017, 18, 4307-4315 (IF: 5.5/Q1, ZJUT Top100, Biology and Biochemistry ESI)

2. Hu Xiong, Hao Zuo, Yunfeng Yan, Gino Occhialini, Kejin Zhou, Yihong Wan, and Daniel J. Siegwart* High-contrast fluorescence detection of metastatic breast cancer including bone and liver micrometastases via size-controlled pH-activatable water-soluble probes. Advanced Materials 2017, 29, 1700131 (IF: 27.4/Q1) 

3. Yunfeng Yan, Kejin Zhou, Hu Xiong, Jason B. Miller, Edward A. Motea, David A. Boothman, Li Liu, and Daniel J. Siegwart* Aerosol Delivery of Stabilized Polyester-siRNA Nanoparticles to Silence Gene Expression in Orthotopic Lung Tumors. Biomaterials 2017, 118, 84-93 (IF: 12.8/Q1)

2017年之前部分论文

Yunfeng Yan, Li Liu, Hu Xiong, Jason B. Miller, Kejin Zhou, Petra Kos, Kenneth E. Huffman, Sussana Elkassih, John W. Norman, Ryan Carstens, James Kim, John D. Minna, and Daniel J. Siegwart* Functional Polyesters Enable Selective siRNA Delivery to Lung Cancer over Matched Normal Cells. Proceedings of the National Academy of Sciences of the United States of America 2016, 113, E5702-E5710. (Highlighted by Chemical Research in Toxicology, Oncology Times, and ScienceDaily)

Kejin Zhou, Liem H. Nguyen, Jason B Miller, Yunfeng Yan, Petra Kos, Lin Li, Jing Hao, Jonathan T Minnig, Hu Xiong, Hao Zhu, and Daniel J Siegwart* Modular Degradable Dendrimers Enable Small RNAs to Extend Survival in an Aggressive Liver Cancer Model. Proceedings of the National Academy of Sciences of the United States of America 2016, 113, 520-525.

Jing Hao, Petra Kos, Kejin Zhou, Jason B Miller, Lian Xue, Yunfeng Yan, Hu Xiong, Sussana Elkassih, Daniel J Siegwart* Rapid Synthesis of a Lipocationic Polyester Library via Ring-opening Polymerization of Functional Valerolactones for Efficacious siRNA Delivery. Journal of the American Chemical Society 2015, 137, 9206–9209.

Yunfeng Yan, Lian Xue, Jason B Miller, Kejin Zhou, Petra Kos, Sussana Elkassih, Li Liu, Atsushi Nagai, Hu Xiong, Daniel J Siegwart* One-pot Synthesis of Functional Poly(aminoester sulfide)s and Utility in Delivering pDNA and siRNA. Polymer 2015, 72, 271-280.

Yunfeng Yan and Daniel Siegwart* Scalable Synthesis and Derivation of Functional Polyesters Bearing Ene and Epoxide Side Chains. Polymer Chemistry 2014, 5, 1362-1371.

Yunfeng Yan, Ebru Kizilay*, Daniel Seeman, Sean Flanagan, Paul L. Dubin*, Lionel Bovetto, Laurence Donato and Christophe Schmitt Heteroprotein Complex Coacervation: Bovine β-Lactoglobulin and Lactoferrin. Langmuir 2013, 29, 15614-15623.

Yunfeng Yan, Daniel Seeman*, Bingqian Zheng, Ebru Kizilay, Yisheng Xu, and Paul L. Dubin* pH-Dependent Aggregation and Disaggregation of Native β-Lactoglobulin in Low Salt. Langmuir 2013, 29, 4584-4593.

授权专利：

1. 燕云峰，刘晓敏，帅棋。一种用于mRNA递送的阳离子脂质分子及其制备方法和用途，ZL202210583271.9。

2. 燕云峰，叶文博，帅棋。一种紫杉醇纳米制剂及其制备方法和应用，ZL202210727659.1。

3. 任天瑞，侯宏伟，王全喜，燕云峰等。一种阿维菌素-蓝藻防紫外缓释微胶囊水分散粒剂及制备方法，ZL201110175539.7。

4. 任天瑞，侯宏伟，王全喜，燕云峰等。阿维菌素-蓝藻防紫外缓释微胶囊杀虫剂及其制备方法，ZL201110175566.4。

担任中国感光学会生物基功能大分子材料与技术专业委员会委员、中国毒理学会青年委员会委员、浙江省毒理学会毒理学替代法专业委员会委员。
长期担任ACS Appl. Mater. Inter. Sci., ACS Nano, Acta Biomater., Chem. Commun., Int. J. Pharmaceut., J. Mater. Chem. B, Nat. Commun.等主流期刊审稿人。

2024 Team Retreat with Dr. Shuai's Group 

2023 Team Retreat with Dr. Shuai's Group