代表性研究论文:
1. Ding W#, Zhao H#, Chen Y, Zhang B, Yang Y, Zang J, Wu J, Lin S*. “Chimeric design of pyrrolysyl-tRNA synthetase/tRNA pairs and canonical synthetase/tRNA pairs for genetic code expansion”, Nat. Commun.,2020, 11, 3154.
2. Zhao H#, Ding W#, Zang J, Yang Y, Liu C, Hu L, Chen Y, Liu G, Fang Y, Yuan Y, Lin S*. “Directed-evolution of a translation system for efficient unnatural amino acids incorporation and generalizable synthetic auxotroph construction”, Nat. Commun.,2021, 12, 7039.
3. Zhao H#, Liu C#, Ding W, Tang L, Fang Y, Chen Y, Hu L, Yuan Y, Fang D, Lin S*. “Manipulating cation-π interactions with genetically encoded tryptophan derivatives”, J. Am. Chem. Soc.,2022, 144, 6742-6748.
4. Zhao H#, Tang L#, Fang Y#, Liu C, Ding W, Zang S, Chen Y, Xu W, Yuan Y, Fang D, Lin S*. “Manipulating cation-π interactions of reader proteins in living cells with genetic code expansion”, J. Am. Chem. Soc., 2023, 145, 30, 16406–16416.
5. Ding W#, Zhao H#, Chen Y#, Lin S*. “New strategies for probing the biological functions of protein post-translational modifications in mammalian cells with genetic code expansion”, Acc. Chem. Res., 2023, 56, 2827-2837.
6. Zang J, Chen Y, Liu C, Hu L, Zhao H, Ding W, Yuan Y, Lin S*. “Genetic code expansion reveals aminoacylated lysine ubiquitination mediated by UBE2W”, Nat. Struct. Mol. Biol., 2023, 30, 62-71.
7. Ding W, Yu W, Chen Y, Lao L, Fang Y, Fang C, Zhao H, Yang B, Lin S*. “Rare codon recoding for efficient noncanonical amino acid incorporation in mammalian cells”, Science, 2024, 384, 1134-1142.
8. Zhang, X.#, Zhu, T.#, Li X.#, Zhao, H., Lin S., Huang, J., Yang, B.*, Guo, X.* DNA damage-induced proteasome phosphorylation controls substrate recognition and facilitates DNA repair. Proc Natl Acad Sci U S A., 2024 Aug 27;121(35) (# Co-first author)
发明专利:
1. 林世贤;赵红霞;唐玲;方誉;一种利用遗传密码扩展提高活细胞内π效应的方法及应用,申请日期:2023-6-26,中国,申请号:CN202310757048.6 (已受理)
2. 林世贤;赵红霞;刘超;方誉;一种利用遗传密码扩展技术提高阳离子-π相互作用的方法及应用,申请日期:2022-2-16,中国,专利号: CN114940979B,公告日:2024-01-23
3. 林世贤;赵红霞;丁文龙;柳光龙;一种引入非天然氨基酸的嵌合体苯丙氨酸翻译系统及其构建方法,申请日期:2021-11-3,中国,申请号:CN202111293920.3 (已受理)
4. 林世贤;赵红霞;丁文龙;柳光龙;嵌合苯丙氨酰-tRNA合成酶/tRNA的应用,申请日期:2019-11-11,中国,专利号:CN111118048B,公告日:2022-06-10
5. 林世贤;柳光龙;丁文龙;赵红霞;一种利用嵌合设计方法构建正交的氨酰-tRNA合成酶/tRNA体系,申请日期:2019-5-24,中国,专利号:CN110172467A,公告日:2019-08-27