• 个人资料

  • 个人简介

      教育经历

      2012/09-2017/06，浙江工业大学，绿色制药协同创新中心，博士，导师：苏为科。

      研究方向为基于机械化学功能性成分的提取以及新型药物递送系统的开发。


      工作经历

          2017/07-至今，浙江工业大学，绿色制药协同创新中心，讲师。



  • 科研项目

    纵向项目：

     （1）主持国家青年科学基金1项，基于“AI+自组装”构筑环糊精三元递药系统，2024-01-01 至 2026-12-31, 30万元, 在研。

      (2) 中华人民共和国科学技术部, 国家重点研发计划 , 2021YFC2101000, 原料药工业菌种改造关键技术及产业示范, 2021-07 至 2025-06, 11749万元, 在研。 

      (3) 浙江省科技厅, 浙江省科技计划项目-重点研发, 2020C03006, 基于本质安全的绿色制药技术开发及产业化应用, 2020-01 至 2023-11, 2400万元, 结题。


    横向项目：

      基于AI的机械化学技术开发，浙江汰泽医药科技有限公司，100万，2023.08-2027.07，主持。


  • 科研成果

    发表的论文：

    1. QH. Zhang; ZH. Lu; C. Su et al. High yielding, one-step mechano-enzymatic hydrolysis of cellulose to cellulose nanocrystals without bulk solvent. Bioresource Technology,2021,331: 125015.

    2. QH. Zhang; ZM. Feng; H. Wang et al. Preparation of camptothecin micelles self-assembled from disodium glycyrrhizin and tannic acid with enhanced antitumor activity. European Journal of Pharmaceutics and Biopharmaceutics,2021,164: 75-85.

    3. QH. Zhang; ZM. Feng; W. Ren et al. Preparation of olmesartan medoxomil solid dispersion with sustained release performance by mechanochemical technology. Drug Delivery and Translational Research,2021, 101546.

    4. QH. Zhang; H. Wang; ZM. Feng et al. Preparation of pectin-tannic acid coated core-shell nanoparticle for enhanced bioavailability and antihyperlipidemic activity of curcumin. Food Hydrocolloids,2021,119: 106858.

    5. QH. Zhang; W. Ren; AV. Dushkin et al. Preparation, characterization, in vitro and in vivo studies of olmesartan medoxomil in a ternary solid dispersion with N-methyl-D-glucamine and hydroxypropyl-β-cyclodextrin. Journal of Drug Delivery Science and Technology, 2020, 56: 101546.   

    6. QH. Zhang; L. Suntsova; YS. Chistyachenko et al. Preparation, physicochemical and pharmacological study of curcumin solid dispersion with an arabinogalactan complexation agent. International Journal of Biological Macromolecules, 2019, 128: 158-166.    

    7. QH. Zhang; NE. Polyakov; YS. Chistyachenko et al. Preparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry. Drug delivery, 2018, 25(1): 198-209.   

    8. QH. Zhang; JB. Yu; LF. Zhang et al. Extraction, characterization, and biological activity of polysaccharidesfrom Sophora flavescens Ait. International Journal of Biological Macromolecules, 2016, 93: 459-467.    

    9. QH. Zhang; JB. Yu; YY. Wang et al. Selective Extraction of Flavonoids from Sophora flavescens Ait. by Mechanochemistry. Molecules, 2016, 21(8): 989-1002.    

    10. XY. Zhu, QH. Zhang; WK. Su*. Solvent-Free N-Arylation of Amines with Arylboronic Acids under Ball Milling Conditions. RSC Advances, 2014, 4: 22775-22778.


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更新时间：
2025-06-29
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更新时间：2025.06.29

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个人资料

  • 单位：
  • 职务：
  • 研究方向：
  • 联系电话：
  • 电子邮箱： zqh1657@zjut.edu.cn
  • 办公地址： 莫干山校区协同中心楼

  • 个人简介

      教育经历

      2012/09-2017/06，浙江工业大学，绿色制药协同创新中心，博士，导师：苏为科。

      研究方向为基于机械化学功能性成分的提取以及新型药物递送系统的开发。


      工作经历

          2017/07-至今，浙江工业大学，绿色制药协同创新中心，讲师。



  • 科研项目

    纵向项目：

     （1）主持国家青年科学基金1项，基于“AI+自组装”构筑环糊精三元递药系统，2024-01-01 至 2026-12-31, 30万元, 在研。

      (2) 中华人民共和国科学技术部, 国家重点研发计划 , 2021YFC2101000, 原料药工业菌种改造关键技术及产业示范, 2021-07 至 2025-06, 11749万元, 在研。 

      (3) 浙江省科技厅, 浙江省科技计划项目-重点研发, 2020C03006, 基于本质安全的绿色制药技术开发及产业化应用, 2020-01 至 2023-11, 2400万元, 结题。


    横向项目：

      基于AI的机械化学技术开发，浙江汰泽医药科技有限公司，100万，2023.08-2027.07，主持。


  • 科研成果

    发表的论文：

    1. QH. Zhang; ZH. Lu; C. Su et al. High yielding, one-step mechano-enzymatic hydrolysis of cellulose to cellulose nanocrystals without bulk solvent. Bioresource Technology,2021,331: 125015.

    2. QH. Zhang; ZM. Feng; H. Wang et al. Preparation of camptothecin micelles self-assembled from disodium glycyrrhizin and tannic acid with enhanced antitumor activity. European Journal of Pharmaceutics and Biopharmaceutics,2021,164: 75-85.

    3. QH. Zhang; ZM. Feng; W. Ren et al. Preparation of olmesartan medoxomil solid dispersion with sustained release performance by mechanochemical technology. Drug Delivery and Translational Research,2021, 101546.

    4. QH. Zhang; H. Wang; ZM. Feng et al. Preparation of pectin-tannic acid coated core-shell nanoparticle for enhanced bioavailability and antihyperlipidemic activity of curcumin. Food Hydrocolloids,2021,119: 106858.

    5. QH. Zhang; W. Ren; AV. Dushkin et al. Preparation, characterization, in vitro and in vivo studies of olmesartan medoxomil in a ternary solid dispersion with N-methyl-D-glucamine and hydroxypropyl-β-cyclodextrin. Journal of Drug Delivery Science and Technology, 2020, 56: 101546.   

    6. QH. Zhang; L. Suntsova; YS. Chistyachenko et al. Preparation, physicochemical and pharmacological study of curcumin solid dispersion with an arabinogalactan complexation agent. International Journal of Biological Macromolecules, 2019, 128: 158-166.    

    7. QH. Zhang; NE. Polyakov; YS. Chistyachenko et al. Preparation of curcumin self-micelle solid dispersion with enhanced bioavailability and cytotoxic activity by mechanochemistry. Drug delivery, 2018, 25(1): 198-209.   

    8. QH. Zhang; JB. Yu; LF. Zhang et al. Extraction, characterization, and biological activity of polysaccharidesfrom Sophora flavescens Ait. International Journal of Biological Macromolecules, 2016, 93: 459-467.    

    9. QH. Zhang; JB. Yu; YY. Wang et al. Selective Extraction of Flavonoids from Sophora flavescens Ait. by Mechanochemistry. Molecules, 2016, 21(8): 989-1002.    

    10. XY. Zhu, QH. Zhang; WK. Su*. Solvent-Free N-Arylation of Amines with Arylboronic Acids under Ball Milling Conditions. RSC Advances, 2014, 4: 22775-22778.


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