Zhongweihong

1993, M.Sc of Biology, Nanjing University, Nanjing, China；

2001, PhD of Biochemical Engineering, Zhejiang Univeristy, Hangzhou,China；

2003-2004 , Visiting Scholar,University of South Florida, Florida, USA；

2009, 2013, Visiting Professor, Rensselaer Polytechnic Institute , New York, USA；

1993-present , Professor, Zhejiang University of Technolgy. Now, Professor Zhong is the Director of Insitute of Microbiology and Fermentation in ZJUT, Associate direct for Zhejiang Provicial Society of Microbiology. 

Recent publications

[1]  Zeling Zhang, Xiaotong Mei, Ziliang He, Xiya Xie, Yang Yang, Chengyu Mei, Dong Xue, Tong Hu, Ming Shu, Weihong Zhong*, Nicotine metabolism pathway in bacteria: mechanism, modification, and application, Applied Microbiology and Biotechnology, 2022, 106(3): 889-904.  

[2] Feng Xiao, Jiazhang Lian, Shuai Tu, Linlin Xie, Jun Li, Fuming Zhang, Robert Linhardt, Haichan Huang, Weihong Zhong*, Metabolic Engineering of Saccharomyces cerevisiae for High-Level Production of Chlorogenic Acid from Glucose, ACS Synthetic Biology, 2022, 11(2): 800-81.

[3] Tong Hu, Chen Yang, Zhengyu Hou, Tengfei Liu, Xiaotong Mei, Weihong Zhong*,  Phthalate esters metabolic strain Gordonia sp. GZ-YC, a potential soil degrader for high concentration Di-(2-ethylhexyl) phthalate, Microorganisms, 2022, 10(3): 641

[4] Chaochao Huang, Lihui Shan, Zeyu Chen, Ziliang He, Jun Li, Yang Yang*, Ming Shu, Fanda Pan, Yang Jiao, Fuming Zhang, Robert J Linhardt, Weihong Zhong*, Differential effect of homologous NicR2A/NicR2Bs and endogenous ectopic strong promoters on nicotine metabolism in Pseudomonas sp. JY-Q, Applied and Environmental Microbiology, 2021, 87(3): e02457-20 

[5] Jun Li, Shanshan Li Linlin Xie, Zeyu Chen, Guoqing Chen, Mingjie Shen, Fanda Pan, Ming Shu, Yang Yang*, Yang Jiao, Fuming Zhang, Robert J Linhardt, Weihong Zhong*, Additional Role of Nicotinic Acid Hydroxylase for the Transformation of 3-Succinoyl-Pyridine by Pseudomonas sp. Strain JY-Q,  Applied and Environmental Microbiology, 2021, 87(6): e02740-20

[6] Jun Li, Linlin Xie, Shulan Qian, Yuhang Tang, Mingjie Shen, Shanshan Li, Jie Wang, Lie Xiong, Jie Lu, and Weihong Zhong, Type VI secretion system facilitates fitness, homeostasis, and competitive advantages for environmental adaptability and efficient nicotine biodegradation, Applied and Environmental Microbiology, 2021, 2021, 87(9):e03113-20

[7] Jun Li, Fengmei Yi, Guoqing Chen, Fanda Pan, Yang Yang*, Ming Shu, Zeyu Chen, Zeling Zhang, Xiaotong Mei, Weihong Zhong*, Function enhancement of a metabolic module via endogenous promoter replacement for Pseudomonas sp. JY-Q to degrade nicotine in tobacco waste treatment, Applied Biochemistry and Biotechnology, 2021, 93(9): 2793-2805

[8] Jun Li, Mingjie Shen, Zeyu Chen, Fanda Pan, Yang Yang*, Ming Shu, Guoqing Chen，Yang Jiao, Fuming Zhang, Robert J. Linhardt, Weihong Zhong*, Expression and functional identification of two homologous nicotine dehydrogenases, NicA2 and Nox, from Pseudomonas sp. JY-Q, Protein Expression and Purification, 2021,178:105767

[9] Peiwu Cui, Yunhai Shao, Yanxin Wang, Rui Zhao, Huihui Zhan, Weihong Zhong*, Co-production of biopolymers and quinone via no-sugar fermentation--a case by Methylobacterium sp. XJLM, Annal of Micorbiology, 2021, 71(1):20

[10] Min Cai, Yin chen, Wang Y, Qiufu Fang, Xinyue He, Wanli Wu, Bao Y, Mao G, Weihua Jin, Weihong Zhong*, Sulfated glucuronomannan hexasaccharide G6S1 enhanced lipolysis and lipophagy via PPAR pathway, International Journal of Biochemistry and Cell Biology, 2021, 106067

[11] Tengfei Liu, Jun Li, Lequan Qiu, Fuming Zhang, Robert J. Linhardt, Weihong Zhong*, Combined genomic and transcriptomic analysis of Dibutyl phthalate metabolic pathway in Arthrobacter sp. ZJUTW, Biotechnology and Bioengineering, 2020, 117(12): 3712-3726

[12] Yunhai Shao, Yanxin Wang, Rui Zhao, Jianmen Chen, Fuming Zhang, Robert J. Linhardt, Weihong Zhong*, Biotechnology progress for removal of indoor gaseous formaldehyde, Applied Microbiology and Biotechnology, 2020, 104(9): 3715-3727

[13] Thérèse Bidja Abena Marie, Guoqing Chen, Zeyu Chen, Xiucheng Zheng, Shanshan Li, Tongtong Li, Weihong Zhong*, Changes in the diversity of soil microbial communities and enrichment of potential petroleum hydrocarbon degraders as a result of crude oil, diesel and gasoline contamination, 3 Biotech, 2020, 10:42

[14] Jun Li, Jie Wang, Shanshan Li, Fengmei Yi, JianXu, Ming Shu, Mingjie Shen, Yang Jiao, Feng Tao, Chengyun Zhu, Hui Zhang, Chengyun Zhu, Jie Wang, Hui Zhang, Shulan Qian, Weihong Zhong*, Co-occurrence of functional modules derived from nicotine degrading gene clusters confers additive effects in Pseudomonas sp. JY-Q, Applied Microbiology and Biotechnology, 2019, 103: 4499- 4510

[15] Hui Zhang, Rui Zhao, Chaochao Huang, Jun Li, Yunhai Shao, Weihong Zhong*, Selectively faster nicotine biodegradation by genomic modified Pseudomonas sp. JY-Q in environment coexisting with glucose, Applied Microbiology and Biotechnology, 2019,103(1): 339-348

[16] Yunhai Shao, Jun Li, Yanxin Wang, Fengmei Yi, Yanan Zhang, Peiwu Cui, Weihong Zhong*, Comparative genomics and transcriptomicsinsights into the C1 metabolic model of a formaldehyde-degrading strain Methylobacterium sp. XJLW, Mol Omics, 2019, 15: 138-149 

[17] Marie Thérèse Bidja Abena, Tongtong Li, Muhammad Naeem Shahc, Weihong Zhong*, Biodegradation of total petroleum hydrocarbons (TPH) in highly contaminated soils by natural attenuation and bioaugmentation, Chemosphere, 2019, 234: 864-874

[18] Yunhai Shao, Yanxin Wang, Fengmei Yi, Yanan Zhang, Wangqian Liu, Chen Yang, HuiMeng, Peiwu Cui, WeihongZhong*, Gaseous formaldehyde degrading by Methylobacterium sp. XJLW, Applied Biochemistry and Biotechnology, 2019, 189(1): 262-272

[19] Weihua Jin, Shuai Li, Jiale Chen, Bing Liu, Jie Li, Xueliang Li, Fuming Zhang, Robert J. Linhardt, WeihongZhong*, Increased soluble heterologous expression of a rat brain 3-O- sulfotransferase 1--a key enzyme for heparin biosynthesis, Protein express and purification, 2018, 151: 23-29

[20] Jun Li, Shulan Qian, Lie Xiong, Chengyun Zhu, Ming Shu, Jie Wang, Yang Jiao, Houlong He, Fuming Zhang, Robert J. Linhardt, WeihongZhong*, Comparative genomics reveals specific genetic architectures in nicotine metabolism of Pseudomonas sp. JY-Q isolated from tobacco waste extracts, Frontiers in Microbiology, 2017, 8:2085. 

[21] Haichan Huang, Xiaobo Liu, Shencong Lv, WeihongZhong*, Fuming Zhang, Robert J. Linhardt, Recombinant Escherichia coli K5 strain with the deletion of waaR gene decreases the molecular weight of the heparosan capsular polysaccharide, 2016, Applied Microbiology and Biotechnology, 2016, 100(18): 7877-7885

[22] Lequn Qiu, Wenwen Chen, Li Zhong, Wanxin Wu, Shijin Wu, Jianmen Chen, Fuming Zhang, Weihong Zhong*, Formaldehyde biodegradation by immobilized Methylobacterium sp XJLW cells in a three-phase fluidized bed reactor, Bioprocess and Biosydtem Engineering, 2014, 37(7): 1377-1384

[23] Lei Zhao, Chenjing Zhu, Yang Gao, Chang Wang, Xuanzhen Li, Ming Shu, Yuping Shi, Weihong Zhong*, Nicotine degradation enhancement by Pseudomonas stutzeri ZCJ during aging process of tobacco leaves, World Journal of Microbiology and Biotechnology, 2012, 28: 2077-2086

[24] Weihong Zhong*, Chenjing Zhu, Min Shu, Kedan Sun, Lei Zhao, Chang Wang, Zijuan Ye, Jianmeng Chen, Nicotine degradation by newly isolated Pseudomonas sp. ZUTSKD in the reconstituted tobacco process from tobacco wastes, Bioresource Technology, 2010, 101, 6935-6941

1. National Key Research and Development Program of China (2021YFA0909500), Design and construct microbial chassis cell for special environment. 2021-2026

2. Key project National Natural Science Foundation of China (21938012)，Basic Study on the enhancement of mass transformation and reaction for biological removal of VOCs. 2020-2024

3. National Natural Science Foundation of China (31970104)，Study on the Function and Interaction of the Analogous clusters for nicotine metabolism in Pseudomonas sp. JY-Q. 2020-2024

4. National Natural Science Foundation of China (31670115)，Removal and mechanism of glucose inhibition on nicotine degradation of Pseudomonas sp. JY-Q in tobacco waste extract. 2017-2020

5.National Natural Science Foundation of China (21076195)，Study on the metabolic control on the production of heparin precursor by E. coli K5. 2011-2013

Editor board member for Microbiology China (ISSN 0253-2654) (2021-2026);  Editorial Board Member for Microorganisms (ISSN 2076-2607)(2022-).