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更新时间:2026.04.13
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赵玉军

| 博士 高校教授 博士生导师

单位:

职务:

研究方向:

办公地址:

办公电话:

电子邮箱: yjzhao@zjut.edu.cn

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  • 个人简介

            赵玉军,教授,博士生导师,入选国家青年人才项目,入聘浙江工业大学C类高层次人才岗位。兼任全国卫生产业企业管理协会精准医疗分会常务理事Scientific Reports和Molecules杂志的Editorial Board Member和客座编辑。

           主持重大新药创制科技重大专项1项、国家自然科学基金面上项目5项、中国科学院战略性先导专项(A)2项,上海市自然科学基金1项,合计主持省部级以上重点科研项目10余项。Cancer Cell, J Am Chem Soc, J Med Chem等国际重要药学领域核心期刊发表研究论文60余篇,申请发明专利20项。荣获2023年上海市浦东新区明珠工程师2023年中国抗癌协会科技奖二等奖(排名第3)、2024年第35届上海市优秀发明选拔赛优秀发明铜奖(排名第3)、2025年上海市药学科技奖优秀成果奖(排名第5)。所参与新药项目,2(MDM2抑制剂、BET抑制剂)已经分别成功转让给Sanofi和Medivation,1MDM2抑制剂获临床试验许可开展了一期临床试验。

          主要主要研究方向为药物化学:小分子调控蛋白质相互作用、蛋白质靶向降解(PROTAC、分子胶等)和核酸靶向降解,激酶抑制剂,以及原创新药的临床前成药性优化。

    研究生培养:招收药学学术博士研究生,药学学术硕士研究生和专业硕士研究生。

    团队招聘青年教师、博士后,欢迎具有药物药学、分子生物学、肿瘤药理学、有机化学、化学合成、生物信息学等相关专业背景的博士(后)加盟团队!

    办公室:浙江省杭州市拱墅区潮王路18号, 子良楼A109, 310014

    Emailyjzhao@zjut.edu.cn

    Wechat:  SophiaWilliam-MI

    ORCID IDhttps://orcid.org/0000-0003-1035-2272

    Researchgate:  https://www.researchgate.net/profile/Yujun-Zhao-3                   


             





  • 育人成果

        2021年,中国科学院上海药物研究所,“最受欢迎授课教师奖”

  • 科研项目

    1.       国家自然科学基金委员会,面上项目,82574229, 合成BFL-1抑制剂和PROTAC降解剂,研究其克服维奈克拉耐药的药学活性,2026-012029-1249万,在研,主持

    2.       国家自然科学基金委员会,面上项目,82273759,设计合成MDM2/4双靶小分子抑制剂和PROTAC降解剂,研究其生物活性,2023-012026-1252万,在研,主持

    3.       MDM2/4双靶小分子抑制剂和PROTAC降解剂的临床候选分子研究, 中国科学院上海药物研究所自主部署科研项目, SIMM0320231008, 2023/10-2025/09, 200, 已结题主持

    4.       上海市自然科学基金,面上项目,22ZR1474500,设计合成MDM2/4双靶抑制剂、研究其抗肿瘤活性,2022-042025-0320万,已结题,主持

    5.       国家自然科学基金委员会,面上项目,82073682TEAD-YAP蛋白相互作用小分子抑制剂的开发及其活性研究,2021-012024-1256万,已结题, 主持

    6.       国家自然科学基金委员会,面上项目,81872724,设计合成新颖的MAP3K14激酶抑制剂和降解剂,研究其生物活性和成药性,2019-012022-1257万,已结题,主持

    7.       国家自然科学基金委员会,面上项目,81673295BET-Bromodomain小分子抑制剂和BET蛋白降解剂的设计合成及其表观遗传学性质研究,2017-012020-1259.00万,已结题,主持

    8.       重大新药创制科技重大专项, 子课题名称:基于蛋白翻译后修饰调控的新药研究关键技术, 2018ZX09711002-004-010, 开发新颖的NIK抑制剂调控IKKα磷酸化和p100降解,研究其成药性, 2018-012020-12, 115.73万,已结题,主持

    9.       中国科学院战略性先导专项(A),项目四、子课题29XDA12040329,新颖ASK1激酶抑制剂的设计、合成及活性研究,2019-012020-0986.05万,已结题,主持

    10.    中国科学院战略性先导专项(A),项目二、子课题22XDA12020322,表观遗传BET Bromodomain小分子抑制剂的开发及其耐药性研究,2016-012017-12100.00万,已结题,主持

    11.    济南市自然科学基金,引进创新团队项目,2021GXRC069,针对蛋白相互作用的肿瘤靶向新药研发创新团队,2022-012024-12120万,已结题,主持


  • 科研成果

    学术论文

    1.   Shijie Zhang, Xi Zhang, Jianfeng Lou, Hongyan Jing, Ziqin Yan, Yi Wang, Yuting Gui, Lan Xu, Xilin Lyu, Yuhang Lu, Zhiyi Wang, Chen Liu, Xiao Xiao, Linghua Meng*, Yujun Zhao*, N-Iminopyridinium ylides as chemically stable pharmacophores enabling targeted degradation of SMARCA proteins, JACS Au, 2026, 6, DOI: 10.1021/jacsau.6c00022, (IF: 8.7, Year 2025) 最后通讯(15/15) 

    2.      Xilin Lyu, Xiancheng Wang, Dongze Lin, Yuhan Lu, Chenxu Wang, Ziqin Yan, Zhiyi Wang, Ying Cheng, Jing Cheng, Xuelian Ren, Yi Su, Shijie Zhang, Yi Chen,* He Huang,* Yujun Zhao* Synthesis of an RBM39 degrader that downregulates CEP192 and induces disorganized spindle structures, Journal of Medicinal Chemistry2025, 68, 7807–7826 (IF: 6.8, Year 2024) 最后通讯 

    3.   Yuhang Lu, Ziqin Yan, Jiaqi Sun, Chenxu Wang, Lan Xu, Xilin Lyu, Xiancheng Wang, Jianfeng Lou, He Huang,* Linghua Meng,* Yujun Zhao*, Selective degradation of TEADs by a PROTAC molecule exhibited robust anticancer efficacy in vitro and in vivoJournal of Medicinal Chemistry2025, 68, 5616-5640. (IF: 6.8, Year 2024) 最后通讯 

    4.    Hanqing Zhao, Xue Li, Xueyu Yao, Shijie Zhang, Yandan Bao, Weiwei Lu, Minyan Xing, Xudong Wang, Xuan Wang,* Yujun Zhao,* Qian Chu,* and Xiaojie Lu*, Influence of macrocyclization strategies on DNA-encoded cyclic 2 peptide libraries, JACS Au, 2025, 5, 3399−3407. (IF: 8.7, Year 2025) 共同通讯

    5.      Zhiyi Wang, Shijie Zhang, Loïca Mélita Irakoze, Yujun Zhao* Targeting p53 activation: Recent therapeutic advances in cancer and diabetic macular edema, European Journal of Medicinal Chemistry2025, 117909. (IF: 5.9, Year 2024) 最后通讯

    6.      Huan Ling, Lin Li, Liping Duan, Weixue Huang, Jiangnan Zheng, Shijie Zhang, Xinling Li, Xiaorong Qiu, Yang Zhou, Nan Ma, Xiaomei Ren, Jinwei Zhang, Zhen Wang, Yujun Zhao, Ruijun Tian, Zhi-Min Zhang*, and Ke Ding,* O-Cyanobenzaldehydes irreversibly modify both buried and exposed lysine residues in live cells, Journal of American Chemical Society2025, 147, 14, 11955–11963 (IF: 14.5, Year 2024)

    7.      Xinyuan Wu, Shunyao Li, Ting Liang, Qing Yu, Yiwei Zhang, Jiaxiang Liu, Kaige Li, Zijian Liu, Mengqing Cui, Yongchao Zhao, Xin Han, Rui Jin, Minjia Tan, Xiaohua Chen, Yujun Zhao, Mingyue Zheng, Yi Sun,* Lu Zhou,* and Xiaojie Lu,* Proteome-wide data guides the discovery of lysine-targeting covalent inhibitors using DNA-encoded chemical libraries, Angewandte Chemie International Edition2025, DOI: 10.1002/anie.202505581 (IF: 16.6, Year 2024)

    8.      MDM2-p53相互作用抑制剂的研究进展和临床现状,张世界,赵玉军,《药学进展》,202549卷,8期,612页。最后通讯 

    9.      Jianfeng Lou, Qianqian Zhou, Xilin Lyu, Xinyi Cen, Chen Liu, Ziqin Yan, Yan Li, Haotian Tang, Qiupei Liu, Jian Ding, Ye Lu, He Huang,* Hua Xie,* Yujun Zhao,* Discovery of a covalent inhibitor that overcame resistance to Venetoclax in AML cells overexpressing BFL-1, Journal of Medicinal Chemistry2024, 67, 10795-10830. (IF: 6.8, Year 2024) 最后通讯 

    10.   Zhitong Lin, Chen Liu, Ziqin Yan, Jing Cheng,Xiancheng Wang, Feilong Zhou, Xilin Lyu, Shiyan Zhang, Daizhou Zhang, Xiangjing Meng,*Yujun Zhao*, Synthesis and Biological Evaluation of 4-Imidazolidinone–Containing Compounds as Potent Inhibitors of the MDM2/p53 Interaction, European Journal of Medicinal Chemistry2024, 116366. (IF: 6.0, Year 2024) 最后通讯 

    11.   Shaozhao Qin, Lijian Feng, Qingyi Zhao, Ziqin Yan, Xilin Lyu, Kaige Li, Baiyang Mu, Yujie Chen, Weiwei Lu, Chao Wang, Yanrui Suo, Jinfeng Yue, Mengqing Cui, Yingjie Li, Yujun Zhao,* Zhiqiang Duan,* Jidong Zhu,* and Xiaojie Lu,* Discovery and Optimization of WDR5 Inhibitors via Cascade 2 Deoxyribonucleic Acid-Encoded Library Selection Approach, Journal of Medicinal Chemistry2024, 67, 1079-1092. (IF: 6.8, Year 2024) 共同通讯 

    12.   Wenhua Zhu, Cuiting Liu, Kang Xi, Anqi Li, Lian Shen, Yana Li, Miaomiao Jia, Yangbo He, Gang Chen, Chenglong Liu, Yangqiang Chen, Kai Chen, Fan Sun, Daizhou Zhang, Chonggang Duan, Heng Wang, Dongdong Wang, Yujun Zhao,* Xiangjing Meng,* Di Zhu,* Discovery of Novel 1-Phenylpiperidine Urea-Containing Derivatives Inhibiting β-Catenin/BCL9 Interaction and Exerting Antitumor Efficacy Through the Activation of Antigen Presentation of cDC1 Cells, Journal of Medicinal Chemistry2024, 67, 12485-12520. (IF: 6.8, Year 2024) 共同通讯

    13.   Jing Cheng, Ziqin Yan, Xinzhi Li, Chen Liu, Linjiang Tong, Xilin Lyu, Bingjie Yang, Zheng Chen,* Yujun Zhao*, Structure-based optimization of indoline-containing compounds as second generation inhibitors of NF-κB-inducing kinase (NIK). Journal of Molecular Structure, 2024, 136755. (IF: 4.0, Year 2024)  最后通讯

    14.   Bo Hou, Jiayi Ye, Lujia Huang, Wenhao Cheng, Fangmin Chen, Huiling Zhou, Jiaxing Pan, Jing Gao, Yi Lai, Yujun Zhao, Wei Huang, Haijun Yu, Zhiai Xu* Tumor-specific delivery of clickable inhibitor for PD-L1 degradation and mitigating resistance of radioimmunotherapy, Science Advances2024, 10, eadq3940  (IF: 11.7, Year 2024)

    15.   Jing Cheng, Ziqin Yan, Kailong Jiang, Chen Liu, Dehua Xu, Xilin Lyu, Xiaobei Hu, Shiyan Zhang, Yubo Zhou,* Jia Li,* Yujun Zhao*, Discovery of JN122, a Spiroindoline-containing Molecule, that Inhibits MDM2/p53 Protein-protein Interaction and Exerts Robust in vivo Antitumor Efficacy. Journal of Medicinal Chemistry2023, 66, 16991-17025. (IF: 7.3, Year 2023) 最后通讯

    16.   Ziqin Yan, Xilin Lyu, Dongze Lin, Gaoxing Wu, Yang Gong, Xuelian Ren, Jian Xiao, Jianfeng Lou, He Huang, Yi Chen*, Yujun Zhao*, Selective degradation of cellular BRD3 and BRD4-L promoted by PROTAC molecules in six cancer cell lines, European Journal of Medicinal Chemistry2023, 115381. (IF: 6.7, Year 2023) 最后通讯

    17.   Ying Cheng, Xilin Lyu, Chen Liu, Xiancheng Wang, Jing Cheng, Daizhou Zhang,  Xiangjing Meng,* Yujun Zhao*, Synthesis and biological evaluation of sclareolide-indole conjugates and their derivatives. Molecules2023, 28, 1737. (IF: 4.92, Year 2022) 最后通讯

    18.   Mengnisa Seydimemet, Yixuan Yang, Yuhan Lv, Jiaxiang Liu, Ziqin Yan, Yujun Zhao*, Xuan Wang*, Xiaojie Lu*, Design, construction, and screening of diversified pyrimidine-focused DNA-encoded libraries, ACS Med. Chem. Lett2023, 14, 1073−1078. (IF: 4.2, Year 2022) 共同通讯

    19.   Shiyan Zhang, Ziqin Yan, Yafang Li, Yang Gong, Xilin Lyu, Jianfeng Lou, Daizhou Zhang, Xiangjing Meng*, Yujun Zhao*, Structure-based discovery of MDM2/4 dual inhibitors that exert antitumor activities against MDM4 -overexpressing cancer cells, Journal of Medicinal Chemistry2022, 65, 6207-6230. (IF: 8.03, Year 2022) 最后通讯

    20.   Xuexin Feng, Ziqin Yan, Feilong Zhou, Jianfeng Lou, Xilin Lyu, Xuelian Ren, Ziyu Zeng, Chenglong Liu, Shiyan Zhang, Di Zhu, He Huang, Jinming Yang*, Yujun Zhao*, Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells, European Journal of Medicinal Chemistry2022, 114327. (IF: 7.08, Year 2022) 最后通讯

    21.   Jianfeng Lou, Yuhang Lu, Jing Cheng, Feilong Zhou, Ziqin Yan, Daizhou Zhang,Xiangjing Meng,* Yujun Zhao*, A chemical perspective on the modulation of TEAD transcriptional activities: Recent progress, challenges, and opportunities, European Journal of Medicinal Chemistry2022, 114684. (IF: 7.08, Year 2022) 最后通讯

    22.   Shiyan Zhang, Jianfeng Lou, Yafang Li, Feilong Zhou, Ziqin Yan, Xilin Lyu, Yujun Zhao*, Recent progress and clinical development of inhibitors that block MDM4/p53 protein-protein interactions, Journal of Medicinal Chemistry2021, 64, 10621–10640. (IF: 7.44, Year 2021) 最后通讯

    23.   Chenglong Liu, Feilong Zhou, Ziqin Yan, Lian Shen, Xichen Zhang, Fenglian He, Xiaojie Lu, Heng Wang, Ker Yu, Yujun Zhao*, Di Zhu*, Discovery of a novel, potent, and selective small-molecule inhibitor of PD-1/PD-L1 interaction with robust in vivo anti-tumor efficacy, British Journal of Pharmacology2021, 178, 2651-2670. (IF8.73, Year 2021) 共同通讯

    24.   Xuan Wang, Jiaxiang Liu, Ziqin Yan, Xiaohong Liu, Sixiu Liu, Yanrui Suo, Weiwei Lu, Jinfeng Yue, Kaixian Chen, Hualiang Jiang, Yujun Zhao*, Mingyue Zheng*, Dongcheng Dai*, Xiaojie Lu*, Diversified strategy for the synthesis of DNA-encoded oxindole libraries, Chemical Science2021, 12, 2841-2847. (IF: 9.82, Year 2021) 共同通讯

    25.   Jing Cheng, Xuexin Feng, Zhiqiang Li, Feilong Zhou, Jin-Ming Yang, Yujun Zhao*, Pharmacological inhibition of NF-κB-inducing Kinase (NIK) with small molecules for the treatment of human diseases, RSC Medicinal Chemistry2021, 12, 552-565. 最后通讯

    26.   Xian Zhou, Xuexin Feng, Dachi Wang, Deheng Chen, Gaoxing Wu, Ziqin Yan, Xilin Lyu, Huan Wang, Jin-Ming Yang,* Yujun Zhao*, Synthesis and bioactivity studies of covalent inhibitors derived from (-)-Chaetominine, Journal of Molecular Structure2021, 1241, 130694. (IF: 3.19, Year 2021) 最后通讯

    27.   Xinzhi Li, Bingchuan Yuan, Min Lu , Yuqin Wang, Na Ding, Chunhong Liu, Ming Gao, Zhicheng Yao, Shiyan Zhang, Yujun Zhao, Liwei Xie, Zheng Chen*,The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression, Nature Communications2021, 12, 7213.

    28.   Zhiqiang Li, Xinzhi Li, Ming-Bo Su, Li-Xin Gao, Yu-Bo Zhou, Bingchuan Yuan, Xilin Lyu, Ziqin Yan, Chujiao Hu, Hao Zhang, Cheng Luo, Zheng Chen*, Jia Li*, Yujun Zhao*, Discovery of a potent and selective NF-κB-inducing kinase (NIK) inhibitor that has anti-inflammatory effects in vitro and in vivo, Journal of Medicinal Chemistry2020, 63, 4388-4407. (IF: 7.44, Year 2021) 最后通讯

    29.   Shiyan Zhang, Chaoying Huang, Xilin Lyu, Peipei Wang, Yi Zang, Zengtao Wang, Huan Wang, Jia Li*, Yujun Zhao*, Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal -regulating kinase 1 (ASK1), European Journal of Medicinal Chemistry2020, 195, 112277. (IF: 6.51, Year 2021) 最后通讯

    30.   Xinzhi Li, Yongsen Wu, Yue Song, Na Ding, Min Lu, Linna Jia, Yujun Zhao, Ming Liu, Zheng Chen*, Activation of NF-kB-inducing kinase in islet β-cells causes β-cell failure and diabetes, Molecular Therapy2020, 2430-2441. (IF: 11.45, Year 2021)

    31.   Deheng Chen, Tian Lu, Ziqin Yan, Wenchao Lu, Feilong Zhou, Xilin Lyu, Biling Xu, Hualiang Jiang, Kaixian Chen, Cheng Luo*, and Yujun Zhao*, Discovery, structural insight, and bioactivities of BY27 as a selective inhibitor of the second bromodomains of BET proteins, European Journal of Medicinal Chemistry2019, 182, 111633. (IF: 6.51, Year 2021) 最后通讯

    32.   Erbao Zhao, Feilong Zhou, and Yujun Zhao*, Lewis Acids Promoted 3+2 Cycloaddition of Oxaziridines and Cyclic Allylic Alcohols through Carbonyl Imine Intermediates, Journal of Organic Chemistry2019, 84 (7), 4282–4293. (IF: 4.35, Year 2021) 最后通讯  

    33.   Deheng Chen, Dexiang Guo, Ziqin Yan, Yujun Zhao*, Allenamide as a bioisostere of acrylamide in design and synthesis of targeted covalent inhibitors MedChemCommun2018, 9, 244-253. (IF: 2.80, Year 2020) 最后通讯 

    34.   Feilong Zhou, Erbao Zhao, Ziqin Yan, Deheng Chen, Yujun Zhao*, Synthesis of 3,4-diarylsubstituted hexahydro-1H-indoles, Tetrahedron Letters2018, 59, 1871-1874. (IF: 2.41, Year 2021) 最后通讯 

    35.   Xiaomeng Ren, Xinzhi Li, Linna Jia, Deheng Chen, Hai Hou, Liangyou Rui, Yujun Zhao*, Zheng Chen*, A small-molecule inhibitor of NF-kB-inducing kinase (NIK) protects liver from toxin-induced inflammation, oxidative stress, and injury, FASEB Journal2017, 2, 711-718. (IF: 5.19, Year 2021) 共同通讯

     

    申请和授权专利:

    1. 赵玉军,楼剑锋,张世界,路宇航,严子琴,一种具有 BFL-1 蛋白结合能力的抑制剂及其制备方法和应用;中国专利申请号: CN2025101510546;申请日期:20250211日;

    2. 赵玉军,蒙凌华,黄河,路宇航,严子琴,吕细林,楼剑锋,孙加奇,徐瓓,王晨旭,任雪莲,一种靶向TEAD的蛋白水解靶向嵌合体及其制备方法和应用;PCT专利申请号:PCT/CN2024/137903;申请日期:20241209日;

    3. 赵玉军,程颖,吕细林,严子琴,周飞龙,草酰二胺衍生物及其用途,中国专利申请号: CN202310218092.X; 申请日期:20230308日;

    4. 赵玉军,李佳,周宇波,程靖,严子琴,吕细林,张世言,周飞龙,刘晨,林芷彤,姜凯龙,徐德华,胡小蓓,具有取代苯基螺[吲哚啉-3,3'-吡咯烷]结构的小分子化合物,PCT专利申请号:WO2024078370;中国专利授权号: ZL202311276504.1;授权日期:20250916日;

    5. 赵玉军,朱棣,周飞龙,严子琴,刘成龙,曾子余,程颖,具有苄氧基芳基醚结构的化合物及其制备方法和用途,PCT专利申请号:WO2023169371;申请日期:20230306日;中国专利授权号: ZL 202380011034.8;授权日期:20260320日;申请日期:20220308日。

    6. 赵玉军,李志强,严子琴,李亚芳,吕细林,周飞龙,苯并含氮五元杂环化合物及其合成和应用,中国专利授权号: ZL202210426932.7;申请日期:20220421日;授权日期:20240806日。

    7. 赵玉军,张世言,严子琴,吕细林,程靖,周飞龙,巩洋,具有取代苯基螺[吲哚啉-3,3’-吡咯烷]结构的小分子化合物,PCT专利申请号: WO2022218379;申请日期:20220414;中国专利申请号: 202110407151; 申请日期:20210415日。

    8. 赵玉军,张世言,严子琴,吕细林,周飞龙,具有4-(取代氨甲基)-5-新戊基-N-取代基吡咯烷-2-甲酰胺结构的化合物,中国专利授权号: ZL202111571938.5;申请日期:20211221日;授权日期:20250504日。

    9. 赵玉军,朱棣,周飞龙,严子琴,刘成龙,张希晨,一种具有苄氧基芳环结构的化合物,其制备方法和用途, PCT专利申请号: WO2020244518, 申请日期: 202006-02; 中国专利授权号: ZL202010491651.0,申请日期: 20200603日。

    10. 赵玉军,王欢,陈德恒,周飞龙,严子琴,吕细林,具有2H-吲唑结果的小分子化合物及其合成和应用,中国专利授权号: ZL202010135402.8, 申请日期: 20200302日。

    11. 赵玉军、李佳、王增涛、张世言、臧奕、王培培、孙丹丹、张含烟, 2-吡啶取代脲结构小分子化合物及其合成和应用,中国专利授权号: ZL201910716810.X, 申请日期: 20190805日。

    12. 赵玉军、陈德恒、郭德祥、严子琴、周飞龙、耿美玉、丁健、沈爱军、刘红椿、张敏敏,一种BRD4 抑制剂及其制备和应用中国专利授权号: ZL201880024931.1, 申请公布日期: 20180413; PCT专利公布号: WO2018/188660, 公布日期: 20181018日。

    13. 赵玉军,李志强,严子琴,李佳,周宇波,苏明波,陈政,一种具有2-氨基嘧啶结构的化合物,其制备方法和用途,中国专利授权号: ZL201811381899.0;申请日期: 20181120日;

    14. 赵玉军、郭德祥、严子琴,含有共轭联烯酰胺结构的化合物、其制备方法、药物组合物和用途中国专利授权号: ZL201711105956.8, 申请日期: 20171110;

    15. 赵玉军、陈德恒、严子琴,郭德祥,含有共轭联烯结构的化合物、其药物组合物和用途中国专利授权号: ZL201710639753.0, 申请日期: 20170731日。

     


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