孙立伟

博士、教授、博士生导师。研究领域为生态毒理学和化学品安全评价。主要以模式鱼斑马鱼及青鳉为动物模型，研究多种环境污染物对水生生物的内分泌、免疫、神经等多个系统的毒性效应和作用机理。已开展的研究工作不仅包括单一化合物的毒性效应，也涉及环境因子和化合物间的复合效应，以及多种不同作用模式化合物间的联合毒性。主持国家自然科学基金面上项目（3项）和青年项目（1项）、省自然科学基金项目（2项）和973子课题等，并参与多项国家和省级科研项目。已发表SCI论文60余篇，他引2300余次。担任国家自然科学基金委函评专家，浙江省自然科学基金重点、杰青项目验收专家。曾获浙江工业大学青年英才支持计划“优青”(2014)、2017年度浙江省毒理学会科技奖（个人奖）等。

教育经历:

2004/09-2007/07：中国科学院生态环境研究中心，水质学国家重点实验室，环境科学专业，博士

2001/09-2004/07：南京大学，环境学院，环境生物学专业，硕士

1997/09-2001/07：南京大学，环境学院，环境科学与工程系，学士

工作经历:

2007/07-至今：浙江工业大学，生环学院/环境学院，讲师/副教授/研究员/教授

2013/12-2014/12：美国俄勒冈州立大学（Oregon State University）环境与分子毒理系访问学者

国家自然科学基金面上项目（22176176, 2022.1-2025.12）微塑料对斑马鱼组织修复与再生能力的影响及毒理机制

浙江省基础公益研究计划项目（LGF22B070009, 2022.1-2024.12）

国家自然科学基金面上项目（21777145, 2018.1-2021.12）

国家自然科学基金面上项目（21377118, 2014.1-2017.12）

国家自然科学基金青年项目（20907044, 2010.1-2012.12）

浙江省自然科学基金面上项目（Y5090265, 2010.1-2011.12）

代表论文：

已发表SCI论文60余篇。部分论文如下：

[1] Gu LQ, Peng SH, Zhang JY, Lu XF, Xia CH, Yu J, Sun LW(通讯作者). Development and validation of an activated immune model with zebrafish eleutheroembryo based on caudal fin acupuncture. Science of the Total Environment. 2021, 785, 147288

[2] Gu LQ, Tian L, Gao G, Peng SH, Zhang JY, Wu D, Huang J, Hua Q, Lu T, Zhong L, Fu ZW, Pan XL, Qian HF, Sun LW(通讯作者). Inhibitory effects of polystyrene microplastics on caudal fin regeneration in zebrafish larvae. Environmental Pollution. 2020, 266, 114664

[3] Sun LW, Gu LQ, Tan HN, Liu P, Gao G, Tian Li, Chen H, Lu T, Qian HF, Fu ZW, Pan XL. Effects of 17α-ethinylestradiol on caudal fin regeneration in zebrafish larvae. Science of the Total Environment. 2019, 653, 10-22

[4] Qian HF, Liu GF, Lu T, Sun LW(通讯作者). Developmental neurotoxicity of Microcystis aeruginosa in the early life stages of zebrafish. Ecotoxicology and Environmental Safety. 2018, 151, 35-41.

[5] Liu GF, Ke MJ, Fan XJ, Zhang M, Zhu YC, Lu T, Sun LW(共同通讯), Qian HF. Reproductive and endocrine-disrupting toxicity of Microcystis aeruginosa in female zebrafish. Chemosphere. 2018, 192, 289-296.

[6] Sun LW, Tan HN, Peng T, Wang SS, Xu WB, Qian HF, Jin YX, Fu ZW. Developmental neurotoxicity of organophosphate flame retardants in early life stages of Japanese medaka (Oryzias latipes). Environmental Toxicology and Chemistry. 2016, 35, 2931-2940

[7] Sun LW, Xu WB, Peng T, Chen HG, Ren L, Tan HN, Xiao D, Qian HF, Fu ZW. Developmental exposure of zebrafish larvae to organophosphate flame retardants causes neurotoxicity. Neurotoxicology and Teratology. 2016, 55, 16-22

[8] Sun LW, Peng T, Liu F, Ren L, Peng ZH, Ji GR, Zhou YF, Fu ZW. Transcriptional responses in male Japanese medaka exposed to antiandrogens and antiandrogen/androgen mixtures. Environmental Toxicology. 2016, 31, 1591-1599

[9] Sun LW, Liu F, Chen HG, Wang SS, Lin X, Chi J, Zhu Q, Fu ZW. Transcriptional responses in adult zebrafish (Danio rerio) exposed to propranolol and metoprolol. Ecotoxicology. 2015, 24, 1352-1361

[10] Sun LW, Ren L, Peng T, Xin LH, Qian HF, Fu ZW. Carbon dioxide enrichment and brassinosteroid pretreatment alleviate chlorpyrifos phytotoxicity under suboptimal light and temperature conditions in tomato. Scientia Horticulturae. 2015, 192, 256-263

[11] Sun LW, Xin LH, Peng ZH, Jin R, Jin YX, Qian HF, Fu ZW. Toxicity and enantiospecific differences of two beta-blockers, propranolol and metoprolol, in the embryos and larvae of zebrafish (Danio rerio). Environmental Toxicology, 2014, 29, 1367-1378.

[12] Sun LW, Jin R, Peng ZH, Zhou QW, Qian HF, Fu ZW. Effects of trilostane and fipronil on the reproductive axis in an early life stage of the Japanese medaka (Oryzias latipes). Ecotoxicology, 2014, 23, 1044-1054.

[13] Sun LW, Shao XL, Chi J, Hu XH, Jin YX, Fu ZW. Transcriptional responses in the brain, liver and gonad of Japanese ricefish (Oryzias latipes) exposed to two anti-estrogens. Comparative Biochemistry and Physiology Part C, 2011, 153, 392-401.

[14] Sun LW, Shao XL, Wu YD, Li JM, Zhou QF, Lin B, Bao SY, Fu ZW. Ontogenetic expression and 17alpha-estradiol regulation of immune-related genes in early life stages of Japanese medaka (Oryzias latipes). Fish & Shellfish Immunology, 2011, 30, 1131-1137.

[15] Sun LW, Shao XL, Hu XH, Chi J, Ye WH, Jin YX, Fu ZW. Transcriptional responses in Japanese medaka (Oryzias latipes) exposed to the binary mixtures of estrogen and anti-estrogens. Aquatic Toxicology, 2011, 105, 629-639

[16] Sun LW, Wen LL, Shao XL, Qian HF, Jin YX, Liu WP, Fu ZW. Screening of chemicals with anti-estrogenic activity using in vitro and in vivo vitellogenin induction responses in zebrafish (Danio rerio). Chemosphere, 2010, 78, 793-799.

[17] Sun LW, Zha JM, Wang ZJ. Effects of binary mixtures of estrogen and antiestrogens on Japanese medaka (Oryzias latipes). Aquatic Toxicology, 2009, 93, 83-89.

[18] Sun LW, Zha JM, Wang ZJ. Interactions between estrogenic chemicals in binary mixtures investigated using vitellogenin induction and factorial analysis. Chemosphere, 2009, 75, 410-415.

[19] Sun LW, Zha JM, Spear PA, Wang ZJ. Toxicity of the aromatase inhibitor letrozole to Japanese medaka (Oryzias latipes) eggs, larvae and breeding adults. Comparative Biochemistry and Physiology Part C, 2007, 145, 533-541.

[20] Sun LW, Zha JM, Spear PA, Wang ZJ. Tamoxifen effects on the early life stages and reproduction of Japanese medaka (Oryzias latipes). Environmental Toxicology and Pharmacology, 2007, 24, 23-29.

出版的教材和专著:

Sun LW, Chi J, Hu XH, Fu ZW. Ecotoxicological effects of tamoxifen in the aquatic environment. In: Tamoxifen Concepts and Cancer: New Paradigms (Editor: Ramon Andrade de Mello, ISBN: 978-1-62081-520-5), Nova Science Publishers, 2013, pp.47-60

生命科学概论（第三版），科学出版社，2016，ISBN: 978-7-03-048187-0，参编